Human Gene H4C11 (ENST00000355057.3_4) from GENCODE V47lift37
  Description: H4 clustered histone 11 (from RefSeq NM_021968.4)
Gencode Transcript: ENST00000355057.3_4
Gencode Gene: ENSG00000197238.5_6
Transcript (Including UTRs)
   Position: hg19 chr6:27,791,870-27,792,258 Size: 389 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr6:27,791,903-27,792,214 Size: 312 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:27,791,870-27,792,258)mRNA (may differ from genome)Protein (103 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
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OMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: H4_HUMAN
DESCRIPTION: RecName: Full=Histone H4;
FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
INTERACTION: Q12830:BPTF; NbExp=3; IntAct=EBI-302023, EBI-1560273; Q12830-4:BPTF; NbExp=16; IntAct=EBI-302023, EBI-4288838; P49450:CENPA; NbExp=4; IntAct=EBI-302023, EBI-1751979; O14929:HAT1; NbExp=4; IntAct=EBI-302023, EBI-2339359; Q9Y468:L3MBTL1; NbExp=3; IntAct=EBI-302023, EBI-1265089; P49736:MCM2; NbExp=3; IntAct=EBI-302023, EBI-374819; P25205:MCM3; NbExp=2; IntAct=EBI-302023, EBI-355153; P33992:MCM5; NbExp=2; IntAct=EBI-302023, EBI-359410; O14744:PRMT5; NbExp=3; IntAct=EBI-302023, EBI-351098; Q16576:RBBP7; NbExp=4; IntAct=EBI-302023, EBI-352227; Q9NQR1:SETD8; NbExp=4; IntAct=EBI-302023, EBI-1268946;
SUBCELLULAR LOCATION: Nucleus. Chromosome.
PTM: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
PTM: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
PTM: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
PTM: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.
PTM: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
PTM: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
PTM: Sumoylated, which is associated with transcriptional repression.
PTM: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
SIMILARITY: Belongs to the histone H4 family.
SEQUENCE CAUTION: Sequence=AAI28106.1; Type=Frameshift; Positions=3;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.03 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 24.81 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.7033-0.233 Picture PostScript Text
3' UTR -11.4044-0.259 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009072 - Histone-fold
IPR007125 - Histone_core_D
IPR001951 - Histone_H4
IPR019809 - Histone_H4_CS

Pfam Domains:
PF02969 - TATA box binding protein associated factor (TAF)
PF15511 - Centromere kinetochore component CENP-T histone fold

SCOP Domains:
47113 - Histone-fold

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2BQZ - X-ray MuPIT 2CV5 - X-ray MuPIT 2RNY - NMR MuPIT 3A6N - X-ray MuPIT 3AFA - X-ray MuPIT 3AN2 - X-ray MuPIT 3AV1 - X-ray MuPIT 3AV2 - X-ray MuPIT 3AYW - X-ray MuPIT 3AZE - X-ray MuPIT 3AZF - X-ray MuPIT 3AZG - X-ray MuPIT 3AZH - X-ray MuPIT 3AZI - X-ray MuPIT 3AZJ - X-ray MuPIT 3AZK - X-ray MuPIT 3AZL - X-ray MuPIT 3AZM - X-ray MuPIT 3AZN - X-ray MuPIT 3CFS - X-ray MuPIT 3CFV - X-ray MuPIT 3F9W - X-ray MuPIT 3F9X - X-ray MuPIT 3F9Y - X-ray MuPIT 3F9Z - X-ray MuPIT 3NQJ - X-ray MuPIT 3NQU - X-ray MuPIT 3O36 - X-ray MuPIT 3QZS - X-ray MuPIT 3QZT - X-ray MuPIT 3QZV - X-ray MuPIT 3R45 - X-ray MuPIT 3UVW - X-ray MuPIT 3UVX - X-ray MuPIT 3UVY - X-ray MuPIT 3UW9 - X-ray MuPIT 4H9N - X-ray 4H9O - X-ray


ModBase Predicted Comparative 3D Structure on P62805
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0042393 histone binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0000183 chromatin silencing at rDNA
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006334 nucleosome assembly
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006352 DNA-templated transcription, initiation
GO:0016233 telomere capping
GO:0032200 telomere organization
GO:0034080 CENP-A containing nucleosome assembly
GO:0044267 cellular protein metabolic process
GO:0045652 regulation of megakaryocyte differentiation
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0051290 protein heterotetramerization
GO:0060964 regulation of gene silencing by miRNA

Cellular Component:
GO:0000228 nuclear chromosome
GO:0000784 nuclear chromosome, telomeric region
GO:0000786 nucleosome
GO:0000788 nuclear nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 macromolecular complex
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK312028 - Homo sapiens cDNA, FLJ92304, Homo sapiens histone 1, H4k (HIST1H4K), mRNA.
LF331261 - JP 2014500723-A/138764: Polycomb-Associated Non-Coding RNAs.
BC017361 - Homo sapiens histone cluster 1, H4j, mRNA (cDNA clone MGC:29783 IMAGE:4647914), complete cds.
BC062345 - Homo sapiens cDNA clone IMAGE:6597408.
AF086564 - Homo sapiens full length insert cDNA clone ZE16D01.
AB463742 - Synthetic construct DNA, clone: pF1KB7212, Homo sapiens H4 gene for Histone H4, without stop codon, in Flexi system.
BC140249 - Synthetic construct Homo sapiens clone IMAGE:100014225, MGC:173196 histone cluster 1, H4j (HIST1H4J) mRNA, encodes complete protein.
BC146523 - Synthetic construct Homo sapiens clone IMAGE:100014882, MGC:180151 histone cluster 1, H4j (HIST1H4J) mRNA, encodes complete protein.
BC148271 - Homo sapiens histone cluster 1, H4j, mRNA (cDNA clone MGC:166960 IMAGE:8860214), complete cds.
BC148485 - Synthetic construct Homo sapiens clone IMAGE:100015442, MGC:183037 histone cluster 1, H4k (HIST1H4K) mRNA, encodes complete protein.
BC153081 - Synthetic construct Homo sapiens clone IMAGE:100016354, MGC:184291 histone cluster 1, H4k (HIST1H4K) mRNA, encodes complete protein.
DQ892605 - Synthetic construct clone IMAGE:100005235; FLH188263.01X; RZPDo839A0673D histone 1, H4f (HIST1H4F) gene, encodes complete protein.
DQ895845 - Synthetic construct Homo sapiens clone IMAGE:100010305; FLH188259.01L; RZPDo839A0663D histone 1, H4f (HIST1H4F) gene, encodes complete protein.
EU446976 - Synthetic construct Homo sapiens clone IMAGE:100070247; IMAGE:100012185; FLH258760.01L histone cluster 1, H4a (HIST1H4A) gene, encodes complete protein.
KJ892518 - Synthetic construct Homo sapiens clone ccsbBroadEn_01912 HIST1H4J gene, encodes complete protein.
BC120940 - Homo sapiens histone cluster 1, H4h, mRNA (cDNA clone MGC:149418 IMAGE:40115074), complete cds.
LF331260 - JP 2014500723-A/138763: Polycomb-Associated Non-Coding RNAs.
DQ579110 - Homo sapiens piRNA piR-47222, complete sequence.
LF331259 - JP 2014500723-A/138762: Polycomb-Associated Non-Coding RNAs.
MA566838 - JP 2018138019-A/138764: Polycomb-Associated Non-Coding RNAs.
MA566837 - JP 2018138019-A/138763: Polycomb-Associated Non-Coding RNAs.
MA566836 - JP 2018138019-A/138762: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P62805 (Reactome details) participates in the following event(s):

R-HSA-3321805 NSL acetylates histone H4
R-HSA-3321883 MSL acetylates histone H4
R-HSA-3662318 Type B histone acetlytransferase complex acetylates histone H4
R-HSA-4570485 SUMOylation of Histone H4 with SUMO3
R-HSA-4570496 SUMOylation of Histone H4 with SUMO1
R-HSA-5205798 PRMT1,PRMT6 methylate arginine-4 of histone H4
R-HSA-5423038 SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)
R-HSA-5423117 PHF8 demethylates MeK21-histone H4
R-HSA-5661124 JMJD6 demethylates MeR4-HIST1H4
R-HSA-5661126 PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4
R-HSA-5661125 JMJD6 demethylates Me2sR4-HIST1H4
R-HSA-5212679 DNMT3A binds Me2sR4-HIST1H4
R-HSA-5651654 SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)
R-HSA-5651657 SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20)
R-HSA-176700 Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure
R-HSA-181450 Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure
R-HSA-5250938 B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
R-HSA-5683930 WICH phosphorylates H2AFX on Y142
R-HSA-1214188 PRDM9 trimethylates histone H3
R-HSA-8935730 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter
R-HSA-8935740 RUNX1 and GATA1 bind the promoter of the ITGA2B gene
R-HSA-8936599 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter
R-HSA-8936616 RUNX1 and GATA1 bind the promoter of the GP1BA gene
R-HSA-8936979 RUNX1 and GATA1 bind the promoter of the THBS1 gene
R-HSA-8936989 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter
R-HSA-8937037 RUNX1 and GATA1 bind the promoter of the MIR27A gene
R-HSA-8937118 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter
R-HSA-5693602 ATM recognizes H2AFX-Nucleosomes
R-HSA-3318415 ATF2 acetylates histone H2B, H4
R-HSA-3301345 Elongator complex acetylates replicative histone H3, H4
R-HSA-3697920 CLOCK acetylates lysine-10 of histone H3, H4
R-NUL-4549261 Elongator complex acetylates H3, H4
R-NUL-4568946 Clock acetylates histones H3, H4
R-HSA-5144542 CLOCK acetylates lysine-15 of histone H3, H4
R-HSA-3321975 NuA4 complex acetylates histone H2A, HIST1H4
R-HSA-3697008 CREBBP acetylates histone H2B, H3, H4
R-HSA-3662335 EP300 acetylates histone H2A, H2B, H3, H4
R-HSA-5205861 COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)
R-HSA-2288097 Condensin II complex binds H4K20me1-containing nucleosomes
R-HSA-2245218 CDK1 phosphorylates PHF8
R-HSA-5684071 RNF4 ubiquitinates MDC1
R-HSA-5693599 Association of Ku heterodimer with ends of DNA double-strand break
R-HSA-3451147 KAT5 HAT complex acetylates TCF4 gene at histone H4
R-HSA-427383 CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9
R-HSA-427528 Formation of energy-dependent Nucleolar Silencing Complex (eNoSC)
R-HSA-5227490 NoRC:HDAC:DNMT methylates cytosine of the rRNA genes
R-HSA-427336 TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
R-HSA-427527 eNoSC dimethylates histone H3 at lysine-9
R-HSA-3788748 EHMT1:EHMT2 methylates IL6 promoter
R-HSA-3788745 EHMT1:EHMT2 methylates IL8 promoter
R-HSA-427337 MBD2 binds methylcytosine in chromatin
R-HSA-9011983 Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes
R-HSA-5334164 DNMT3B:DNMT3L binds chromatin
R-HSA-5334179 DNMT3A:DNMT3L binds chromatin
R-HSA-5578742 AGO1,2:small RNA complexes interact with chromatin
R-HSA-427514 eNoSC deacetylates histone H3
R-HSA-3240295 PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter
R-HSA-3222593 KDM6B demethylates H3K27me3 on p16-INK4A promoter
R-HSA-5334151 DNMT1 methylates cytosine in hemimethylated DNA
R-HSA-5334160 UHRF1:Chromatin binds DNMT1
R-HSA-5334099 UHRF1 binds chromatin with hemimethylated cytosine
R-HSA-8865491 RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene
R-HSA-9011949 KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers
R-HSA-3229089 PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter
R-HSA-3229102 p-MAPKAPK3 phosphorylates BMI1
R-HSA-606326 HJURP:CENPA complex localizes to the centromere
R-HSA-912467 BRCA1 is recruited to unsynapsed regions
R-HSA-912470 ATR phosphorylates Histone H2A.X at unsynapsed regions
R-HSA-5693583 MDC1 associates with gamma-H2AFX at nuclear foci
R-HSA-5683967 EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
R-HSA-8936481 Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter
R-HSA-8936621 Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter
R-HSA-8937016 Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter
R-HSA-8937050 Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter
R-HSA-8936584 PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter
R-HSA-8936608 PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter
R-HSA-8937022 PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter
R-HSA-8937113 PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter
R-HSA-9009371 Binding of AP1 transcriptional activator complexes to CCND1 promoter
R-HSA-9009065 FOXA1 and GATA3 bind to CCND1 promoter
R-HSA-2301205 SETD8 monomethylates histone H4
R-HSA-2172678 PHF8 demethylates histone H4K20me1
R-HSA-3364026 SET1 complex trimethylates H3K4 at the MYC gene
R-HSA-3769447 HDAC1/2 containing-complexes deacetylate histones
R-HSA-3777129 HDAC3 containing complexes deacetylate histone
R-HSA-3782637 HDAC8 deacetylates histones
R-HSA-3782655 HDAC10 deacetylates histone
R-HSA-5625774 PKN1:AR complex binds promoters of KLK2 and KLK3 genes
R-HSA-9011952 ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers
R-HSA-5625849 Demethylase KDM1A binds KLK2 and KLK3 promoters
R-HSA-5625797 KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters
R-HSA-5625870 KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters
R-HSA-5693549 ATM phosphorylates histone H2AFX on S139 at DNA DSBs
R-HSA-5683986 APBB1 and MAPK8 bind diphosphorylated H2AFX
R-HSA-9011984 KDM1A is recruited to MYC and BCL2 genes
R-HSA-9011981 EP300 is recruited to MYC and BCL2 genes
R-HSA-9011985 KDM1A demethylates H3 on MYC and BCL genes in response to estrogen
R-HSA-2294600 CDK1 phosphorylates condensin II subunit NCAPD3
R-HSA-2294580 PLK1 hyperphosphorylates Condensin II complex
R-HSA-2294590 PLK1 binds phosphorylated condensin II complex
R-HSA-212263 PRC2 trimethylates histone H3 at lysine-27
R-HSA-212222 PRC2 recruits DNA methyltransferases
R-HSA-5334097 DNMT3B:DNMT3L methylates cytosine in DNA
R-HSA-5334152 DNMT3A:DNMT3L methylates cytosine in DNA
R-HSA-8865498 KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark
R-HSA-912450 ATR Kinase is recruited to unsynapsed regions
R-HSA-5682967 WHSC1 binds DNA DSBs
R-HSA-5693536 ATM phosphorylates MDC1
R-HSA-5625784 PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters
R-HSA-5625796 Demethylase KDM4C binds KLK2 and KLK3 promoters
R-HSA-5625848 KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters
R-HSA-5683964 ATM phosphorylates EYA1-4
R-HSA-977224 Serum amyloid P binds DNA and chromatin
R-HSA-5682983 ATM phosphorylates WHSC1
R-HSA-5682965 WHSC1 dimethylates histone H4 on lysine K21 at DSBs
R-HSA-5682992 KDM4A,B bind H4K20Me2
R-HSA-5682588 RNF8 binds phosphorylated MDC1 at DNA DSBs
R-HSA-5693566 TP53BP1 associates with H4K20Me2 at DNA DSBs
R-HSA-5683077 RNF8 and RNF168 ubiquitinate KDM4A,B
R-HSA-5682586 HERC2 and PIAS4 are recruited to DNA DSBs
R-HSA-5682629 HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
R-HSA-5682607 PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
R-HSA-5682863 RNF168 binds DNA DSBs
R-HSA-5682858 RNF8 and RNF168 ubiquitinate H2AFX
R-HSA-5683384 UIMC1 and FAM175A bind DNA DSBs
R-HSA-5683405 PPP5C dephosphorylates TP53BP1
R-HSA-5683425 ATM phosphorylates TP53BP1 at DNA DSBs
R-HSA-5682598 ATM phosphorylates HERC2
R-HSA-5693551 Phosphorylation of BRCA1-A complex at multiple sites by ATM
R-HSA-5683385 Formation of BRCA1-A complex at DNA DSBs
R-HSA-5683735 CHEK2 is recruited to DNA DSBs
R-HSA-5683801 CHEK2 phosphorylates BRCA1
R-HSA-69891 Phosphorylation and activation of CHEK2 by ATM
R-HSA-5684052 PIAS4 SUMOylates MDC1
R-HSA-5686685 RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
R-HSA-5686900 TP53BP1 recruits DCLRE1C to ATM
R-HSA-5686704 Activated ATM phosphorylates DCLRE1C
R-HSA-3214847 HATs acetylate histones
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3214842 HDMs demethylate histones
R-HSA-171306 Packaging Of Telomere Ends
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-912446 Meiotic recombination
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-1221632 Meiotic synapsis
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-157579 Telomere Maintenance
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-5334118 DNA methylation
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-1500620 Meiosis
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-3214815 HDACs deacetylate histones
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-4839726 Chromatin organization
R-HSA-2990846 SUMOylation
R-HSA-68875 Mitotic Prophase
R-HSA-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-2559583 Cellular Senescence
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-73886 Chromosome Maintenance
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-8939211 ESR-mediated signaling
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-211000 Gene Silencing by RNA
R-HSA-774815 Nucleosome assembly
R-HSA-1474165 Reproduction
R-HSA-1640170 Cell Cycle
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-212436 Generic Transcription Pathway
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-597592 Post-translational protein modification
R-HSA-977225 Amyloid fiber formation
R-HSA-68886 M Phase
R-HSA-5693538 Homology Directed Repair
R-HSA-73894 DNA Repair
R-HSA-2262752 Cellular responses to stress
R-HSA-195721 Signaling by WNT
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-74160 Gene expression (Transcription)
R-HSA-1266738 Developmental Biology
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-195258 RHO GTPase Effectors
R-HSA-392499 Metabolism of proteins
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-162582 Signal Transduction
R-HSA-194315 Signaling by Rho GTPases
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints

-  Other Names for This Gene
  Alternate Gene Symbols: A2VCL0, ENST00000355057.1, ENST00000355057.2, H4-16, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4C1, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, H4_HUMAN, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4, NM_021968, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7, uc317yxl.1, uc317yxl.2
UCSC ID: ENST00000355057.3_4
RefSeq Accession: NM_021968.4
Protein: P62805 (aka H4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.