ID:HDAC3_HUMAN DESCRIPTION: RecName: Full=Histone deacetylase 3; Short=HD3; EC=3.5.1.98; AltName: Full=RPD3-2; AltName: Full=SMAP45; FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (By similarity). CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. SUBUNIT: Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation (By similarity). Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15 (By similarity). INTERACTION: P43356:MAGEA2B; NbExp=4; IntAct=EBI-607682, EBI-5650739; Q9UIS9:MBD1; NbExp=3; IntAct=EBI-607682, EBI-867196; O75376:NCOR1; NbExp=2; IntAct=EBI-607682, EBI-347233; Q8CBD1:Nrip1 (xeno); NbExp=2; IntAct=EBI-607682, EBI-1771626; P12504:vif (xeno); NbExp=2; IntAct=EBI-607682, EBI-779991; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed. PTM: Sumoylated in vitro. SIMILARITY: Belongs to the histone deacetylase family. HD type 1 subfamily. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HDAC3ID40804ch5q31.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15379
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001934 positive regulation of protein phosphorylation GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006476 protein deacetylation GO:0007623 circadian rhythm GO:0016575 histone deacetylation GO:0019216 regulation of lipid metabolic process GO:0031647 regulation of protein stability GO:0032008 positive regulation of TOR signaling GO:0042307 positive regulation of protein import into nucleus GO:0043066 negative regulation of apoptotic process GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046329 negative regulation of JNK cascade GO:0051225 spindle assembly GO:0070932 histone H3 deacetylation GO:0071498 cellular response to fluid shear stress GO:1903507 negative regulation of nucleic acid-templated transcription GO:0010832 negative regulation of myotube differentiation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
