Human Gene HBA1 (ENST00000320868.9_4) from GENCODE V47lift37
  Description: hemoglobin subunit alpha 1 (from RefSeq NM_000558.5)
Gencode Transcript: ENST00000320868.9_4
Gencode Gene: ENSG00000206172.8_7
Transcript (Including UTRs)
   Position: hg19 chr16:226,679-227,521 Size: 843 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr16:226,716-227,410 Size: 695 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:226,679-227,521)mRNA (may differ from genome)Protein (142 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: HBA_HUMAN
DESCRIPTION: RecName: Full=Hemoglobin subunit alpha; AltName: Full=Alpha-globin; AltName: Full=Hemoglobin alpha chain;
FUNCTION: Involved in oxygen transport from the lung to the various peripheral tissues.
SUBUNIT: Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA); two alpha chains and two delta chains in adult hemoglobin A2 (HbA2); two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two alpha chains and two gamma chains in fetal hemoglobin F (HbF).
INTERACTION: P68871:HBB; NbExp=19; IntAct=EBI-714680, EBI-715554;
TISSUE SPECIFICITY: Red blood cells.
PTM: The initiator Met is not cleaved in variant Thionville and is acetylated.
DISEASE: Defects in HBA1 may be a cause of Heinz body anemias (HEIBAN) [MIM:140700]. This is a form of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency.
DISEASE: Defects in HBA1 are the cause of alpha-thalassemia (A- THAL) [MIM:604131]. The thalassemias are the most common monogenic diseases and occur mostly in Mediterranean and Southeast Asian populations. The hallmark of alpha-thalassemia is an imbalance in globin-chain production in the adult HbA molecule. The level of alpha chain production can range from none to very nearly normal levels. Deletion of both copies of each of the two alpha-globin genes causes alpha(0)-thalassemia, also known as homozygous alpha thalassemia. Due to the complete absence of alpha chains, the predominant fetal hemoglobin is a tetramer of gamma-chains (Bart hemoglobin) that has essentially no oxygen carrying capacity. This causes oxygen starvation in the fetal tissues leading to prenatal lethality or early neonatal death. The loss of three alpha genes results in high levels of a tetramer of four beta chains (hemoglobin H), causing a severe and life-threatening anemia known as hemoglobin H disease. Untreated, most patients die in childhood or early adolescence. The loss of two alpha genes results in mild alpha-thalassemia, also known as heterozygous alpha-thalassemia. Affected individuals have small red cells and a mild anemia (microcytosis). If three of the four alpha-globin genes are functional, individuals are completely asymptomatic. Some rare forms of alpha-thalassemia are due to point mutations (non- deletional alpha-thalassemia). The thalassemic phenotype is due to unstable globin alpha chains that are rapidly catabolized prior to formation of the alpha-beta heterotetramers.
DISEASE: Note=Alpha(0)-thalassemia is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non- immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders.
DISEASE: Defects in HBA1 are the cause of hemoglobin H disease (HBH) [MIM:613978]. HBH is a form of alpha-thalassemia due to the loss of three alpha genes. This results in high levels of a tetramer of four beta chains (hemoglobin H), causing a severe and life-threatening anemia. Untreated, most patients die in childhood or early adolescence.
MISCELLANEOUS: Gives blood its red color.
SIMILARITY: Belongs to the globin family.
SEQUENCE CAUTION: Sequence=BAD97112.1; Type=Erroneous initiation;
WEB RESOURCE: Name=HbVar; Note=Human hemoglobin variants and thalassemias; URL="http://globin.bx.psu.edu/cgi-bin/hbvar/query_vars3?mode=directlink&gene=HBA1";
WEB RESOURCE: Name=HbVar; Note=Human hemoglobin variants and thalassemias; URL="http://globin.bx.psu.edu/cgi-bin/hbvar/query_vars3?mode=directlink&gene=HBA2";
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/HBA1";
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/HBA2";
WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HBA1";
WEB RESOURCE: Name=Wikipedia; Note=Hemoglobin entry; URL="http://en.wikipedia.org/wiki/Hemoglobin";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HBA1
Diseases sorted by gene-association score: thalassemias, alpha-* (737), hemoglobin h disease, nondeletional* (631), heinz body anemia* (303), hydrops fetalis, nonimmune* (202), methemoglobinemia, beta-globin type* (202), hemoglobinopathy (19), alpha-thalassemia/mental retardation syndrome, chromosome 16-related* (18), cardiovascular cancer (17), thalassemia (17), hobnail hemangioma (16), ovarian angiosarcoma (16), ovary sarcoma (16), intravascular fasciitis (15), angiomyoma (15), pediatric angiosarcoma (15), peritoneal benign neoplasm (14), benign peritoneal mesothelioma (14), brain sarcoma (14), immune hydrops fetalis (14), hydrops fetalis (13), integumentary system benign neoplasm (12), histiocytoid hemangioma (11), vascular hemostatic disease (11), thyroid angiosarcoma (11), thyroid sarcoma (11), breast angiosarcoma (11), glomeruloid hemangioma (11), bone epithelioid hemangioma (11), spleen cancer (10), capillary lymphangioma (10), venous hemangioma (10), spleen angiosarcoma (10), skin hemangioma (10), acquired hemangioma (9), lymphangiosarcoma (9), conventional angiosarcoma (9), capillary hemangioma (8), angiokeratoma of fordyce (8), pneumatosis cystoides intestinalis (8), pulmonary artery leiomyosarcoma (8), neurogenic arthropathy (8), breast sarcoma (7), lymphangitis (7), adenoid squamous cell carcinoma (7), diabetes mellitus, insulin-dependent, 24 (7), favism (7), hypochromic microcytic anemia (7), heart cancer (7), sickle cell anemia (7), langerhans cell sarcoma (7), hemangioma of liver (6), extraosseous osteosarcoma (6), microcytic anemia (6), interstitial emphysema (6), mixed liposarcoma (6), pericardium cancer (6), hemangioma of intra-abdominal structure (5), liver angiosarcoma (5), mesenchymal cell neoplasm (5), vascular cancer (5), immature cataract (5), miliaria (5), chondroid lipoma (5), diabetes mellitus, insulin-dependent, 7 (5), spindle cell liposarcoma (5), meninges hemangiopericytoma (5), hemangiopericytoma, malignant (5), senile angioma (5), diabetes mellitus, insulin-dependent, 11 (5), chorioangioma (5), hereditary spastic paraplegia 3a (5), infiltrating lipoma (4), skin benign neoplasm (4), angiomatous meningioma (4), congenital epulis (4), malaria (4), cloacogenic carcinoma (4), pericardial mesothelioma (4), retinal vascular disease (4), low compliance bladder (4), glomangioma (4), nephrogenic adenofibroma (3), cardiovascular organ benign neoplasm (3), benign perivascular tumor (3), malignant dermis tumor (3), sialolithiasis (3), indeterminate leprosy (3), stroke, ischemic (2), diabetes mellitus, insulin-dependent (2), connective tissue cancer (1), glucose metabolism disease (1), acquired metabolic disease (1), diabetes mellitus, noninsulin-dependent (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35830.80 RPKM in Whole Blood
Total median expression: 36775.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.2037-0.276 Picture PostScript Text
3' UTR -29.50111-0.266 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000971 - Globin
IPR009050 - Globin-like
IPR012292 - Globin_dom
IPR002338 - Haemoglobin_a
IPR018331 - Haemoglobin_alpha_chain
IPR002339 - Haemoglobin_pi

Pfam Domains:
PF00042 - Globin

SCOP Domains:
46458 - Globin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1A00 - X-ray MuPIT 1A01 - X-ray MuPIT 1A0U - X-ray MuPIT 1A0Z - X-ray MuPIT 1A3N - X-ray 1A3O - X-ray 1A9W - X-ray 1ABW - X-ray MuPIT 1ABY - X-ray MuPIT 1AJ9 - X-ray 1B86 - X-ray 1BAB - X-ray MuPIT 1BBB - X-ray MuPIT 1BIJ - X-ray 1BUW - X-ray 1BZ0 - X-ray 1BZ1 - X-ray MuPIT 1BZZ - X-ray MuPIT 1C7B - X-ray MuPIT 1C7C - X-ray MuPIT 1C7D - X-ray MuPIT 1CLS - X-ray 1CMY - X-ray MuPIT 1COH - X-ray MuPIT 1DKE - X-ray 1DXT - X-ray MuPIT 1DXU - X-ray MuPIT 1DXV - X-ray MuPIT 1FDH - X-ray MuPIT 1FN3 - X-ray 1G9V - X-ray 1GBU - X-ray 1GBV - X-ray 1GLI - X-ray MuPIT 1GZX - X-ray 1HAB - X-ray 1HAC - X-ray 1HBA - X-ray MuPIT 1HBB - X-ray MuPIT 1HBS - X-ray MuPIT 1HCO - X-ray MuPIT 1HDB - X-ray MuPIT 1HGA - X-ray MuPIT 1HGB - X-ray MuPIT 1HGC - X-ray MuPIT 1HHO - X-ray MuPIT 1IRD - X-ray 1J3Y - X-ray 1J3Z - X-ray 1J40 - X-ray 1J41 - X-ray 1J7S - X-ray MuPIT 1J7W - X-ray MuPIT 1J7Y - X-ray MuPIT 1JY7 - X-ray 1K0Y - X-ray 1K1K - X-ray 1KD2 - X-ray 1LFL - X-ray 1LFQ - X-ray 1LFT - X-ray 1LFV - X-ray 1LFY - X-ray 1LFZ - X-ray 1LJW - X-ray 1M9P - X-ray 1MKO - X-ray 1NEJ - X-ray 1NIH - X-ray MuPIT 1NQP - X-ray 1O1I - X-ray MuPIT 1O1J - X-ray MuPIT 1O1K - X-ray MuPIT 1O1L - X-ray MuPIT 1O1M - X-ray MuPIT 1O1N - X-ray MuPIT 1O1O - X-ray MuPIT 1O1P - X-ray MuPIT 1QI8 - X-ray MuPIT 1QSH - X-ray 1QSI - X-ray 1QXD - X-ray 1QXE - X-ray 1R1X - X-ray 1R1Y - X-ray 1RPS - X-ray 1RQ3 - X-ray 1RQ4 - X-ray 1RQA - X-ray MuPIT 1RVW - X-ray MuPIT 1SDK - X-ray 1SDL - X-ray 1SHR - X-ray 1SI4 - X-ray 1THB - X-ray MuPIT 1UIW - X-ray 1VWT - X-ray MuPIT 1XXT - X-ray 1XY0 - X-ray MuPIT 1XYE - X-ray MuPIT 1XZ2 - X-ray 1XZ4 - X-ray MuPIT 1XZ5 - X-ray MuPIT 1XZ7 - X-ray MuPIT 1XZU - X-ray MuPIT 1XZV - X-ray MuPIT 1Y01 - X-ray MuPIT 1Y09 - X-ray MuPIT 1Y0A - X-ray MuPIT 1Y0C - X-ray MuPIT 1Y0D - X-ray 1Y0T - X-ray MuPIT 1Y0W - X-ray MuPIT 1Y22 - X-ray MuPIT 1Y2Z - X-ray MuPIT 1Y31 - X-ray MuPIT 1Y35 - X-ray MuPIT 1Y45 - X-ray MuPIT 1Y46 - X-ray MuPIT 1Y4B - X-ray MuPIT 1Y4F - X-ray MuPIT 1Y4G - X-ray MuPIT 1Y4P - X-ray MuPIT 1Y4Q - X-ray MuPIT 1Y4R - X-ray MuPIT 1Y4V - X-ray MuPIT 1Y5F - X-ray MuPIT 1Y5J - X-ray MuPIT 1Y5K - X-ray MuPIT 1Y7C - X-ray MuPIT 1Y7D - X-ray MuPIT 1Y7G - X-ray MuPIT 1Y7Z - X-ray MuPIT 1Y83 - X-ray MuPIT 1Y85 - X-ray 1Y8W - X-ray MuPIT 1YDZ - X-ray MuPIT 1YE0 - X-ray MuPIT 1YE1 - X-ray MuPIT 1YE2 - X-ray MuPIT 1YEN - X-ray MuPIT 1YEO - X-ray MuPIT 1YEQ - X-ray MuPIT 1YEU - X-ray MuPIT 1YEV - X-ray MuPIT 1YFF - X-ray 1YG5 - X-ray MuPIT 1YGD - X-ray MuPIT 1YGF - X-ray MuPIT 1YH9 - X-ray 1YHE - X-ray 1YHR - X-ray 1YIE - X-ray MuPIT 1YIH - X-ray MuPIT 1YVQ - X-ray MuPIT 1YVT - X-ray MuPIT 1YZI - X-ray 1Z8U - X-ray MuPIT 2D5Z - X-ray 2D60 - X-ray 2DN1 - X-ray 2DN2 - X-ray 2DN3 - X-ray 2DXM - Neutron MuPIT 2H35 - NMR MuPIT 2HBC - X-ray MuPIT 2HBD - X-ray MuPIT 2HBE - X-ray MuPIT 2HBF - X-ray MuPIT 2HBS - X-ray 2HCO - X-ray MuPIT 2HHB - X-ray 2HHD - X-ray 2HHE - X-ray MuPIT 2W6V - X-ray 2W72 - X-ray MuPIT 2YRS - X-ray 3B75 - X-ray 3D17 - X-ray 3D7O - X-ray 3DUT - X-ray 3HHB - X-ray 3HXN - X-ray 3IA3 - X-ray MuPIT 3IC0 - X-ray 3IC2 - X-ray 3KMF - Neutron 3NL7 - X-ray MuPIT 3NMM - X-ray MuPIT 3ODQ - X-ray 3ONZ - X-ray 3OO4 - X-ray 3OO5 - X-ray 3OVU - X-ray MuPIT 3P5Q - X-ray 3QJB - X-ray MuPIT 3QJC - X-ray MuPIT 3QJD - X-ray MuPIT 3QJE - X-ray MuPIT 3R5I - X-ray 3S48 - X-ray 3S65 - X-ray MuPIT 3S66 - X-ray MuPIT 3SZK - X-ray 4HHB - X-ray MuPIT 6HBW - X-ray


ModBase Predicted Comparative 3D Structure on P69905
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005344 oxygen transporter activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0004601 peroxidase activity
GO:0031720 haptoglobin binding

Biological Process:
GO:0006898 receptor-mediated endocytosis
GO:0010942 positive regulation of cell death
GO:0015671 oxygen transport
GO:0015701 bicarbonate transport
GO:0042542 response to hydrogen peroxide
GO:0042744 hydrogen peroxide catabolic process
GO:0051291 protein heterooligomerization
GO:0098869 cellular oxidant detoxification

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005833 hemoglobin complex
GO:0016020 membrane
GO:0022627 cytosolic small ribosomal subunit
GO:0031838 haptoglobin-hemoglobin complex
GO:0070062 extracellular exosome
GO:0071682 endocytic vesicle lumen
GO:0072562 blood microparticle


-  Descriptions from all associated GenBank mRNAs
  KX533500 - Homo sapiens Hemoglobin subunit alpha (HBA2) mRNA, complete cds.
JD326111 - Sequence 307135 from Patent EP1572962.
AK223392 - Homo sapiens mRNA for alpha 2 globin variant, clone: FCC107C11.
BC005931 - Homo sapiens hemoglobin, alpha 1, mRNA (cDNA clone MGC:14541 IMAGE:4047053), complete cds.
BC101846 - Homo sapiens hemoglobin, alpha 1, mRNA (cDNA clone MGC:126895 IMAGE:8069352), complete cds.
BC101848 - Homo sapiens hemoglobin, alpha 1, mRNA (cDNA clone MGC:126897 IMAGE:8069354), complete cds.
AF349571 - Homo sapiens hemoglobin alpha-1 globin chain (HBA1) mRNA, complete cds.
BC032122 - Homo sapiens hemoglobin, alpha 1, mRNA (cDNA clone MGC:29691 IMAGE:4849981), complete cds.
BC050661 - Homo sapiens hemoglobin, alpha 1, mRNA (cDNA clone MGC:60177 IMAGE:5209215), complete cds.
AF105974 - Homo sapiens alpha one globin (HBA1) mRNA, complete cds.
JD041152 - Sequence 22176 from Patent EP1572962.
DQ894945 - Synthetic construct Homo sapiens clone IMAGE:100009405; FLH179688.01L; RZPDo839B06131D hemoglobin, alpha 2 (HBA2) gene, encodes complete protein.
DQ896383 - Synthetic construct Homo sapiens clone IMAGE:100010843; FLH193822.01L; RZPDo839C0669D hemoglobin, alpha 2 (HBA2) gene, encodes complete protein.
DQ891761 - Synthetic construct clone IMAGE:100004391; FLH179692.01X; RZPDo839B06132D hemoglobin, alpha 2 (HBA2) gene, encodes complete protein.
DQ893109 - Synthetic construct clone IMAGE:100005739; FLH193826.01X; RZPDo839C0679D hemoglobin, alpha 2 (HBA2) gene, encodes complete protein.
AB590168 - Synthetic construct DNA, clone: pFN21AE1112, Homo sapiens HBA1 gene for hemoglobin, alpha 1, without stop codon, in Flexi system.
JD020180 - Sequence 1204 from Patent EP1572962.
JD032226 - Sequence 13250 from Patent EP1572962.
AF281258 - Homo sapiens alpha one globin (HBA1) mRNA, partial cds.
LP886339 - Sequence 231 from Patent WO2017201352.
LP886340 - Sequence 232 from Patent WO2017201352.
LP978096 - Sequence 231 from Patent WO2017120612.
LP978097 - Sequence 232 from Patent WO2017120612.
JD201218 - Sequence 182242 from Patent EP1572962.
MB419118 - JP 2019519516-A/80: MRNA COMBINATION THERAPIES FOR THE TREATMENT OF CANCER.
MB419119 - JP 2019519516-A/81: MRNA COMBINATION THERAPIES FOR THE TREATMENT OF CANCER.
MB419983 - JP 2019519516-A/945: MRNA COMBINATION THERAPIES FOR THE TREATMENT OF CANCER.
MB419984 - JP 2019519516-A/946: MRNA COMBINATION THERAPIES FOR THE TREATMENT OF CANCER.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_ahspPathway - Hemoglobin's Chaperone

Reactome (by CSHL, EBI, and GO)

Protein P69905 (Reactome details) participates in the following event(s):

R-HSA-2168884 Ferriheme is transferred from Methemoglobin to Hemopexin
R-HSA-6806831 CYB5Rs reduce MetHb to HbA
R-HSA-1237325 Hemoglobin A is protonated and carbamated causing release of oxygen
R-HSA-1247668 Hemoglobin A binds oxygen and releases protons and carbon dioxide
R-HSA-2168885 Haptoglobin binds Hemoglobin
R-HSA-2168889 Haptoglobin-related Protein binds Hemoglobin
R-HSA-2168883 Haptoglobin:Hemoglobin binds CD163
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-1480926 O2/CO2 exchange in erythrocytes
R-HSA-5653656 Vesicle-mediated transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000320868.1, ENST00000320868.2, ENST00000320868.3, ENST00000320868.4, ENST00000320868.5, ENST00000320868.6, ENST00000320868.7, ENST00000320868.8, HBA2, HBA_HUMAN, NM_000558, P01922, P69905, Q1HDT5, Q3MIF5, Q53F97, Q96KF1, Q9NYR7, Q9UCM0, uc317qyq.1, uc317qyq.2
UCSC ID: ENST00000320868.9_4
RefSeq Accession: NM_000558.5
Protein: P69905 (aka HBA_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene HBA1:
a-thal (Alpha-Thalassemia)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.