The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81901 - HCP-like 48439 - Protein prenylyltransferase 48452 - TPR-like 116846 - MIT domain
ModBase Predicted Comparative 3D Structure on Q9Y5Q9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0005515 protein binding GO:0000995 transcription factor activity, core RNA polymerase III binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006359 regulation of transcription from RNA polymerase III promoter GO:0006383 transcription from RNA polymerase III promoter GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter GO:0042797 tRNA transcription from RNA polymerase III promoter
BC036952 - Homo sapiens cDNA clone IMAGE:5500100, containing frame-shift errors. BC043347 - Homo sapiens general transcription factor IIIC, polypeptide 3, 102kDa, mRNA (cDNA clone MGC:49899 IMAGE:5498609), complete cds. AF133123 - Homo sapiens transcription factor IIIC102 mRNA, complete cds. AK025560 - Homo sapiens cDNA: FLJ21907 fis, clone HEP03803, highly similar to AF133123 Homo sapiens transcription factor IIIC102 mRNA. AK314718 - Homo sapiens cDNA, FLJ95577, Homo sapiens general transcription factor IIIC, polypeptide 3,102kDa (GTF3C3), mRNA. KJ897997 - Synthetic construct Homo sapiens clone ccsbBroadEn_07391 GTF3C3 gene, encodes complete protein. AB385239 - Synthetic construct DNA, clone: pF1KB9483, Homo sapiens GTF3C3 gene for general transcription factor 3C polypeptide 3, complete cds, without stop codon, in Flexi system. AF465407 - Homo sapiens transcription factor IIIC102 short isoform mRNA, complete cds. AL137453 - Homo sapiens mRNA; cDNA DKFZp761E129 (from clone DKFZp761E129); partial cds. BC015995 - Homo sapiens, Similar to general transcription factor IIIC, polypeptide 3 (102kD), clone IMAGE:4106590, mRNA, partial cds. AF085850 - Homo sapiens full length insert cDNA clone YI50E01. AH004836 - Homo sapiens 50kda protein gene {5' and 3' regions, clone CEM1001} [human, lymphoblastoid cell line CEM, mRNA Partial, 671 nt 2 segments]. AK027050 - Homo sapiens cDNA: FLJ23397 fis, clone HEP17977. JD470417 - Sequence 451441 from Patent EP1572962. JD313942 - Sequence 294966 from Patent EP1572962. JD450557 - Sequence 431581 from Patent EP1572962. JD440284 - Sequence 421308 from Patent EP1572962. JD509747 - Sequence 490771 from Patent EP1572962. BC026889 - Homo sapiens general transcription factor IIIC, polypeptide 3, 102kDa, mRNA (cDNA clone IMAGE:4939007), with apparent retained intron. JD450981 - Sequence 432005 from Patent EP1572962. JD219063 - Sequence 200087 from Patent EP1572962. JD272796 - Sequence 253820 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_RNApol3Pathway - RNA polymerase III transcription
Reactome (by CSHL, EBI, and GO)
Protein Q9Y5Q9 (Reactome details) participates in the following event(s):
R-HSA-76054 Binding of TFIIIC to TFIIIA:Type I Promoter complex R-HSA-83788 Binding of TFIIIC to Type 2 promoter R-HSA-83723 Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex R-HSA-83790 Binding of TFIIIB to TFIIC: Type 2 Promoter Complex R-HSA-112055 RNA Polymerase III Abortive Initiation At Type 1 Open Promoters R-HSA-112153 RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters R-HSA-76060 RNA Polymerase III Promoter Opening at Type 1 Promoters R-HSA-112149 RNA Polymerase III Abortive Initiation At Type 2 Open Promoters R-HSA-112155 RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters R-HSA-112150 RNA Polymerase III Promoter Opening at Type 2 Promoters R-HSA-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex R-HSA-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76046 RNA Polymerase III Transcription Initiation R-HSA-74158 RNA Polymerase III Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
