Human Gene GSK3B (ENST00000264235.13_11) from GENCODE V47lift37
  Description: glycogen synthase kinase 3 beta, transcript variant 2 (from RefSeq NM_001146156.2)
Gencode Transcript: ENST00000264235.13_11
Gencode Gene: ENSG00000082701.17_20
Transcript (Including UTRs)
   Position: hg19 chr3:119,540,168-119,813,294 Size: 273,127 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr3:119,545,635-119,812,281 Size: 266,647 Coding Exon Count: 11 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:119,540,168-119,813,294)mRNA (may differ from genome)Protein (420 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GSK3B
Diseases sorted by gene-association score: alzheimer disease (19), bipolar disorder (12), usher syndrome, type 2a (10), familial adenomatous polyposis (7), adenomatous polyposis coli (7), multiple symmetrical lipomatosis (6), alzheimer disease-2 (6), aneurysmal bone cysts (6), chromosome 1q41-q42 deletion syndrome (5), usher syndrome, type 1b (5), parkinson disease susceptibility (5), usher syndrome type 2 (5), glioblastoma multiforme (4), deafness, autosomal recessive 6 (4), neuroblastoma (3), colorectal cancer (3), breast cancer (2), prostate cancer (2), schizophrenia (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.97 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 361.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -389.601013-0.385 Picture PostScript Text
3' UTR -1451.705467-0.266 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q6FI27
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  HW061153 - JP 2012529430-A/28: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061154 - JP 2012529430-A/29: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JA482108 - Sequence 91 from Patent WO2011072091.
JA482109 - Sequence 92 from Patent WO2011072091.
JB251961 - Sequence 28 from Patent EP2440214.
JB251962 - Sequence 29 from Patent EP2440214.
JE980400 - Sequence 91 from Patent EP2862929.
JE980401 - Sequence 92 from Patent EP2862929.
LP764860 - Sequence 28 from Patent EP3276004.
LP764861 - Sequence 29 from Patent EP3276004.
E08052 - cDNA encoding human tauproteinkinase-1.
BC012760 - Homo sapiens glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:16182 IMAGE:3637163), complete cds.
BC000251 - Homo sapiens glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:1736 IMAGE:3357620), complete cds.
HH837100 - Sequence 27 from Patent EP2231168.
HI214741 - Sequence 27 from Patent EP2076526.
HV601543 - JP 2011500003-A/27: Novel siRNA Structures.
HV856616 - JP 2010507387-A/27: Novel siRNAs and Methods of Use Thereof.
HW165103 - JP 2013102767-A/27: Novel siRNA's and Use Thereof.
HW675611 - JP 2014210789-A/27: Novel siRNA Structures.
HW835299 - JP 2015051004-A/27: Novel siRNA's and Use Thereof.
JA538142 - Sequence 27 from Patent EP2371958.
L33801 - Human protein kinase mRNA, complete cds.
AK290897 - Homo sapiens cDNA FLJ75266 complete cds, highly similar to Homo sapiens glycogen synthase kinase 3 beta, mRNA.
CR536510 - Homo sapiens full open reading frame cDNA clone RZPDo834A0920D for gene GSK3B, glycogen synthase kinase 3 beta; complete cds, incl. stopcodon.
EU302497 - Homo sapiens GSK3beta isoform (GSK3B) mRNA, complete cds.
DQ892501 - Synthetic construct clone IMAGE:100005131; FLH186921.01X; RZPDo839B1172D glycogen synthase kinase 3 beta (GSK3B) gene, encodes complete protein.
DQ895714 - Synthetic construct Homo sapiens clone IMAGE:100010174; FLH186917.01L; RZPDo839B1162D glycogen synthase kinase 3 beta (GSK3B) gene, encodes complete protein.
AB451356 - Homo sapiens GSK3B mRNA for glycogen synthase kinase-3 beta, partial cds, clone: FLJ08025AAAF.
AB385047 - Synthetic construct DNA, clone: pF1KB5120, Homo sapiens GSK3B gene for glycogen synthase kinase-3 beta, complete cds, without stop codon, in Flexi system.
BX640779 - Homo sapiens mRNA; cDNA DKFZp686L15210 (from clone DKFZp686L15210).
FW340081 - Screening.
AY123976 - Homo sapiens glycogen synthase kinase 3 beta (GSK3B) mRNA, partial cds, alternatively spliced.
JD025094 - Sequence 6118 from Patent EP1572962.
JD028553 - Sequence 9577 from Patent EP1572962.
JD433984 - Sequence 415008 from Patent EP1572962.
JD328113 - Sequence 309137 from Patent EP1572962.
JD468352 - Sequence 449376 from Patent EP1572962.
JD073655 - Sequence 54679 from Patent EP1572962.
JD360131 - Sequence 341155 from Patent EP1572962.
JD380049 - Sequence 361073 from Patent EP1572962.
JD557074 - Sequence 538098 from Patent EP1572962.
JD315982 - Sequence 297006 from Patent EP1572962.
JD349446 - Sequence 330470 from Patent EP1572962.
JD056229 - Sequence 37253 from Patent EP1572962.
JD271291 - Sequence 252315 from Patent EP1572962.
JD458510 - Sequence 439534 from Patent EP1572962.
JD406055 - Sequence 387079 from Patent EP1572962.
JD458514 - Sequence 439538 from Patent EP1572962.
JD271292 - Sequence 252316 from Patent EP1572962.
JD057274 - Sequence 38298 from Patent EP1572962.
JD406801 - Sequence 387825 from Patent EP1572962.
JD461601 - Sequence 442625 from Patent EP1572962.
JD056228 - Sequence 37252 from Patent EP1572962.
JD458513 - Sequence 439537 from Patent EP1572962.
JD458511 - Sequence 439535 from Patent EP1572962.
JD458512 - Sequence 439536 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_g1Pathway - Cell Cycle: G1/S Check Point
h_gsk3Pathway - Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
h_igf1mtorpathway - Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
h_p35alzheimersPathway - Deregulation of CDK5 in Alzheimers Disease
h_shhPathway - Sonic Hedgehog (Shh) Pathway
h_ptdinsPathway - Phosphoinositides and their downstream targets.
h_alkPathway - ALK in cardiac myocytes
h_hesPathway - Segmentation Clock
h_ps1Pathway - Presenilin action in Notch and Wnt signaling
h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
h_pitx2Pathway - Multi-step Regulation of Transcription by Pitx2
h_wntPathway - WNT Signaling Pathway
h_eif2Pathway - Regulation of eIF2

-  Other Names for This Gene
  Alternate Gene Symbols: D3DN88, ENST00000264235.1, ENST00000264235.10, ENST00000264235.11, ENST00000264235.12, ENST00000264235.2, ENST00000264235.3, ENST00000264235.4, ENST00000264235.5, ENST00000264235.6, ENST00000264235.7, ENST00000264235.8, ENST00000264235.9, GSK3B , hCG_1818062 , NM_001146156, Q6FI27, Q6FI27_HUMAN, uc317hqo.1, uc317hqo.2
UCSC ID: ENST00000264235.13_11
RefSeq Accession: NM_001146156.2
Protein: Q6FI27

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.