The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine and serine/threonine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q6FI27
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HW061153 - JP 2012529430-A/28: METHODS FOR TREATING CHRONIC KIDNEY DISEASE. HW061154 - JP 2012529430-A/29: METHODS FOR TREATING CHRONIC KIDNEY DISEASE. JA482108 - Sequence 91 from Patent WO2011072091. JA482109 - Sequence 92 from Patent WO2011072091. JB251961 - Sequence 28 from Patent EP2440214. JB251962 - Sequence 29 from Patent EP2440214. JE980400 - Sequence 91 from Patent EP2862929. JE980401 - Sequence 92 from Patent EP2862929. LP764860 - Sequence 28 from Patent EP3276004. LP764861 - Sequence 29 from Patent EP3276004. E08052 - cDNA encoding human tauproteinkinase-1. BC012760 - Homo sapiens glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:16182 IMAGE:3637163), complete cds. BC000251 - Homo sapiens glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:1736 IMAGE:3357620), complete cds. HH837100 - Sequence 27 from Patent EP2231168. HI214741 - Sequence 27 from Patent EP2076526. HV601543 - JP 2011500003-A/27: Novel siRNA Structures. HV856616 - JP 2010507387-A/27: Novel siRNAs and Methods of Use Thereof. HW165103 - JP 2013102767-A/27: Novel siRNA's and Use Thereof. HW675611 - JP 2014210789-A/27: Novel siRNA Structures. HW835299 - JP 2015051004-A/27: Novel siRNA's and Use Thereof. JA538142 - Sequence 27 from Patent EP2371958. L33801 - Human protein kinase mRNA, complete cds. AK290897 - Homo sapiens cDNA FLJ75266 complete cds, highly similar to Homo sapiens glycogen synthase kinase 3 beta, mRNA. CR536510 - Homo sapiens full open reading frame cDNA clone RZPDo834A0920D for gene GSK3B, glycogen synthase kinase 3 beta; complete cds, incl. stopcodon. EU302497 - Homo sapiens GSK3beta isoform (GSK3B) mRNA, complete cds. DQ892501 - Synthetic construct clone IMAGE:100005131; FLH186921.01X; RZPDo839B1172D glycogen synthase kinase 3 beta (GSK3B) gene, encodes complete protein. DQ895714 - Synthetic construct Homo sapiens clone IMAGE:100010174; FLH186917.01L; RZPDo839B1162D glycogen synthase kinase 3 beta (GSK3B) gene, encodes complete protein. AB451356 - Homo sapiens GSK3B mRNA for glycogen synthase kinase-3 beta, partial cds, clone: FLJ08025AAAF. AB385047 - Synthetic construct DNA, clone: pF1KB5120, Homo sapiens GSK3B gene for glycogen synthase kinase-3 beta, complete cds, without stop codon, in Flexi system. BX640779 - Homo sapiens mRNA; cDNA DKFZp686L15210 (from clone DKFZp686L15210). FW340081 - Screening. AY123976 - Homo sapiens glycogen synthase kinase 3 beta (GSK3B) mRNA, partial cds, alternatively spliced. JD025094 - Sequence 6118 from Patent EP1572962. JD028553 - Sequence 9577 from Patent EP1572962. JD433984 - Sequence 415008 from Patent EP1572962. JD328113 - Sequence 309137 from Patent EP1572962. JD468352 - Sequence 449376 from Patent EP1572962. JD073655 - Sequence 54679 from Patent EP1572962. JD360131 - Sequence 341155 from Patent EP1572962. JD380049 - Sequence 361073 from Patent EP1572962. JD557074 - Sequence 538098 from Patent EP1572962. JD315982 - Sequence 297006 from Patent EP1572962. JD349446 - Sequence 330470 from Patent EP1572962. JD056229 - Sequence 37253 from Patent EP1572962. JD271291 - Sequence 252315 from Patent EP1572962. JD458510 - Sequence 439534 from Patent EP1572962. JD406055 - Sequence 387079 from Patent EP1572962. JD458514 - Sequence 439538 from Patent EP1572962. JD271292 - Sequence 252316 from Patent EP1572962. JD057274 - Sequence 38298 from Patent EP1572962. JD406801 - Sequence 387825 from Patent EP1572962. JD461601 - Sequence 442625 from Patent EP1572962. JD056228 - Sequence 37252 from Patent EP1572962. JD458513 - Sequence 439537 from Patent EP1572962. JD458511 - Sequence 439535 from Patent EP1572962. JD458512 - Sequence 439536 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_g1Pathway - Cell Cycle: G1/S Check Point h_gsk3Pathway - Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages h_igf1mtorpathway - Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway h_p35alzheimersPathway - Deregulation of CDK5 in Alzheimers Disease h_shhPathway - Sonic Hedgehog (Shh) Pathway h_ptdinsPathway - Phosphoinositides and their downstream targets. h_alkPathway - ALK in cardiac myocytes h_hesPathway - Segmentation Clock h_ps1Pathway - Presenilin action in Notch and Wnt signaling h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_pitx2Pathway - Multi-step Regulation of Transcription by Pitx2 h_wntPathway - WNT Signaling Pathway h_eif2Pathway - Regulation of eIF2
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
