Human Gene GRAP2 (ENST00000344138.9_4) from GENCODE V47lift37
  Description: GRB2 related adaptor protein 2, transcript variant 3 (from RefSeq NM_004810.4)
Gencode Transcript: ENST00000344138.9_4
Gencode Gene: ENSG00000100351.17_9
Transcript (Including UTRs)
   Position: hg19 chr22:40,297,088-40,369,725 Size: 72,638 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr22:40,343,111-40,367,088 Size: 23,978 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:40,297,088-40,369,725)mRNA (may differ from genome)Protein (330 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q6FI14_HUMAN
DESCRIPTION: SubName: Full=GRAP2 protein; SubName: Full=GRB2-related adaptor protein 2, isoform CRA_a; SubName: Full=cDNA, FLJ93267, Homo sapiens GRB2-related adaptor protein 2 (GRAP2), mRNA;
SIMILARITY: Contains 2 SH3 domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.70 RPKM in Whole Blood
Total median expression: 39.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.40261-0.281 Picture PostScript Text
3' UTR -976.502637-0.370 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000980 - SH2
IPR001452 - SH3_domain

Pfam Domains:
PF00017 - SH2 domain
PF00018 - SH3 domain
PF07653 - Variant SH3 domain
PF14604 - Variant SH3 domain

SCOP Domains:
50044 - SH3-domain
52218 - Flavoproteins
55550 - SH2 domain

ModBase Predicted Comparative 3D Structure on Q6FI14
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Descriptions from all associated GenBank mRNAs
  AY069959 - Homo sapiens Mona (GRAP2) mRNA, complete cds.
AK303332 - Homo sapiens cDNA FLJ50399 complete cds, highly similar to GRB2-related adapter protein 2.
AK303512 - Homo sapiens cDNA FLJ50433 complete cds, highly similar to GRB2-related adapter protein 2.
AF236119 - Homo sapiens cell-line H93D8 T cell adapter protein GRID (GRID) mRNA, complete cds.
AJ011736 - Homo sapiens mRNA for growth factor receptor binding protein (GRBLG).
BC025692 - Homo sapiens GRB2-related adaptor protein 2, mRNA (cDNA clone MGC:34486 IMAGE:5208327), complete cds.
AF042380 - Homo sapiens Grf40 adaptor protein (Grf40) mRNA, complete cds.
AF102694 - Homo sapiens Grb2-related adaptor protein 2 (GRAP2) mRNA, complete cds.
AF129476 - Homo sapiens hematopoietic cell-associated adaptor protein GrpL mRNA, complete cds.
AF090456 - Homo sapiens Grb-2-like protein mRNA, complete cds.
JD468430 - Sequence 449454 from Patent EP1572962.
JD292973 - Sequence 273997 from Patent EP1572962.
CR456498 - Homo sapiens GRAP2 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.GRAP2.V3).
JD051968 - Sequence 32992 from Patent EP1572962.
Y18051 - Homo sapiens mRNA for GADS protein.
AK312830 - Homo sapiens cDNA, FLJ93267, Homo sapiens GRB2-related adaptor protein 2 (GRAP2), mRNA.
AK303657 - Homo sapiens cDNA FLJ52042 complete cds, highly similar to GRB2-related adapter protein 2.
AK303280 - Homo sapiens cDNA FLJ52037 complete cds, highly similar to GRB2-related adapter protein 2.
AK303470 - Homo sapiens cDNA FLJ52039 complete cds, highly similar to GRB2-related adapter protein 2.
AF121002 - Homo sapiens SH3-SH2-SH3 adaptor (Mona) mRNA, complete cds.
BC026002 - Homo sapiens GRB2-related adaptor protein 2, mRNA (cDNA clone MGC:27357 IMAGE:4672797), complete cds.
KJ892761 - Synthetic construct Homo sapiens clone ccsbBroadEn_02155 GRAP2 gene, encodes complete protein.
AB463056 - Synthetic construct DNA, clone: pF1KB8650, Homo sapiens GRAP2 gene for GRB2-related adaptor protein 2, without stop codon, in Flexi system.
CU013383 - Homo sapiens GRAP2, mRNA (cDNA clone IMAGE:100000258), complete cds, without stop codon, in Gateway system.
DQ896431 - Synthetic construct Homo sapiens clone IMAGE:100010891; FLH194254.01L; RZPDo839H0269D GRB2-related adaptor protein 2 (GRAP2) gene, encodes complete protein.
DQ893144 - Synthetic construct clone IMAGE:100005774; FLH194258.01X; RZPDo839H0279D GRB2-related adaptor protein 2 (GRAP2) gene, encodes complete protein.
CU013095 - Homo sapiens GRAP2, mRNA (cDNA clone IMAGE:100000354), complete cds, with stop codon, in Gateway system.
JD354980 - Sequence 336004 from Patent EP1572962.
CR541849 - Homo sapiens full open reading frame cDNA clone RZPDo834H0232D for gene GRAP2, GRB2-related adaptor protein 2; complete cds, without stopcodon.
AF236120 - Homo sapiens cell-line Jurkat J6 T cell lymphoma adapter protein GRID (GRID) mRNA, complete cds.
CR536524 - Homo sapiens full open reading frame cDNA clone RZPDo834F0120D for gene GRAP2, GRB2-related adaptor protein 2; complete cds, incl. stopcodon.
AX274631 - Sequence 2200 from Patent WO0162911.
AX274632 - Sequence 2201 from Patent WO0162911.
AX274633 - Sequence 2202 from Patent WO0162911.
AX274634 - Sequence 2203 from Patent WO0162911.
AX274635 - Sequence 2204 from Patent WO0162911.
AX274636 - Sequence 2205 from Patent WO0162911.
AX274637 - Sequence 2206 from Patent WO0162911.
AX274638 - Sequence 2207 from Patent WO0162911.
AX274639 - Sequence 2208 from Patent WO0162911.
AX274640 - Sequence 2209 from Patent WO0162911.
AX274641 - Sequence 2210 from Patent WO0162911.
AX274642 - Sequence 2211 from Patent WO0162911.
JD170334 - Sequence 151358 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000344138.1, ENST00000344138.2, ENST00000344138.3, ENST00000344138.4, ENST00000344138.5, ENST00000344138.6, ENST00000344138.7, ENST00000344138.8, GRAP2 , hCG_41723 , NM_004810, Q6FI14, Q6FI14_HUMAN, uc317wvw.1, uc317wvw.2
UCSC ID: ENST00000344138.9_4
RefSeq Accession: NM_004810.4
Protein: Q6FI14

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.