Human Gene GPR75 (ENST00000394705.3_7) from GENCODE V47lift37
  Description: G protein-coupled receptor 75 (from RefSeq NM_006794.4)
Gencode Transcript: ENST00000394705.3_7
Gencode Gene: ENSG00000119737.6_10
Transcript (Including UTRs)
   Position: hg19 chr2:54,080,049-54,087,104 Size: 7,056 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr2:54,080,271-54,081,893 Size: 1,623 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:54,080,049-54,087,104)mRNA (may differ from genome)Protein (540 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR75_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 75;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GPR75
Diseases sorted by gene-association score: doyne honeycomb degeneration of retina (9)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.78 RPKM in Brain - Caudate (basal ganglia)
Total median expression: 60.81 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -102.30249-0.411 Picture PostScript Text
3' UTR -41.10222-0.185 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on O95800
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0016493 C-C chemokine receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0070098 chemokine-mediated signaling pathway
GO:1901214 regulation of neuron death

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC110915 - Homo sapiens ankyrin repeat and SOCS box-containing 3, mRNA (cDNA clone MGC:132002 IMAGE:5764788), complete cds.
LF209018 - JP 2014500723-A/16521: Polycomb-Associated Non-Coding RNAs.
AF072693 - Homo sapiens G protein-coupled receptor 75 (GPR75) mRNA, complete cds.
BC067475 - Homo sapiens G protein-coupled receptor 75, mRNA (cDNA clone MGC:79309 IMAGE:6971705), complete cds.
JD182399 - Sequence 163423 from Patent EP1572962.
BC067476 - Homo sapiens G protein-coupled receptor 75, mRNA (cDNA clone MGC:79310 IMAGE:6971810), complete cds.
JD490620 - Sequence 471644 from Patent EP1572962.
AK314885 - Homo sapiens cDNA, FLJ95786, Homo sapiens G protein-coupled receptor 75 (GPR75), mRNA.
CU688302 - Synthetic construct Homo sapiens gateway clone IMAGE:100022974 5' read GPR75 mRNA.
LF325238 - JP 2014500723-A/132741: Polycomb-Associated Non-Coding RNAs.
LF325237 - JP 2014500723-A/132740: Polycomb-Associated Non-Coding RNAs.
JD477241 - Sequence 458265 from Patent EP1572962.
LF325233 - JP 2014500723-A/132736: Polycomb-Associated Non-Coding RNAs.
MA560815 - JP 2018138019-A/132741: Polycomb-Associated Non-Coding RNAs.
MA560814 - JP 2018138019-A/132740: Polycomb-Associated Non-Coding RNAs.
MA560810 - JP 2018138019-A/132736: Polycomb-Associated Non-Coding RNAs.
MA444595 - JP 2018138019-A/16521: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RC02, ENST00000394705.1, ENST00000394705.2, GPR75_HUMAN, NM_006794, O95800, Q6NWR2, uc318wvp.1, uc318wvp.2
UCSC ID: ENST00000394705.3_7
RefSeq Accession: NM_006794.4
Protein: O95800 (aka GPR75_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.