Human Gene GPR162 (ENST00000311268.8_4) from GENCODE V47lift37
  Description: G protein-coupled receptor 162, transcript variant A-2 (from RefSeq NM_019858.2)
Gencode Transcript: ENST00000311268.8_4
Gencode Gene: ENSG00000250510.8_10
Transcript (Including UTRs)
   Position: hg19 chr12:6,930,987-6,936,586 Size: 5,600 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr12:6,933,065-6,936,369 Size: 3,305 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:6,930,987-6,936,586)mRNA (may differ from genome)Protein (588 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GP162_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 162; AltName: Full=Gene-rich cluster gene A protein;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 92.79 RPKM in Brain - Cerebellum
Total median expression: 590.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -230.00511-0.450 Picture PostScript Text
3' UTR -74.60217-0.344 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR022347 - GPCR_153/162
IPR022348 - GPCR_162
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10328 - Serpentine type 7TM GPCR chemoreceptor Srx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q16538
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LP895837 - Sequence 701 from Patent EP3253886.
AK316512 - Homo sapiens cDNA, FLJ79411 complete cds, highly similar to Probable G-protein coupled receptor 162.
BC002353 - Homo sapiens G protein-coupled receptor 162, mRNA (cDNA clone MGC:8427 IMAGE:2821031), complete cds.
U47925 - Human protein A alternatively spliced form 1 (A-1) mRNA, complete cds.
U47928 - Human protein A alternatively spliced form 2 (A-2) mRNA, complete cds.
BC080585 - Homo sapiens G protein-coupled receptor 162, mRNA (cDNA clone MGC:99617 IMAGE:3510624), complete cds.
AK315938 - Homo sapiens cDNA, FLJ78837 complete cds, highly similar to Probable G-protein coupled receptor 162.
BC007918 - Homo sapiens G protein-coupled receptor 162, mRNA (cDNA clone IMAGE:4301475), partial cds.
AK296359 - Homo sapiens cDNA FLJ56513 complete cds, highly similar to Probable G-protein coupled receptor 162.
JD292758 - Sequence 273782 from Patent EP1572962.
JD178808 - Sequence 159832 from Patent EP1572962.
JD183932 - Sequence 164956 from Patent EP1572962.
JD150380 - Sequence 131404 from Patent EP1572962.
JD157483 - Sequence 138507 from Patent EP1572962.
JD411364 - Sequence 392388 from Patent EP1572962.
JD372014 - Sequence 353038 from Patent EP1572962.
JF432663 - Synthetic construct Homo sapiens clone IMAGE:100073901 G protein-coupled receptor 162 (GPR162) gene, encodes complete protein.
KJ893616 - Synthetic construct Homo sapiens clone ccsbBroadEn_03010 GPR162 gene, encodes complete protein.
JD426321 - Sequence 407345 from Patent EP1572962.
JD172814 - Sequence 153838 from Patent EP1572962.
AB464432 - Synthetic construct DNA, clone: pF1KB9521, Homo sapiens GRP162 gene for Probable G-protein coupled receptor 162, without stop codon, in Flexi system.
AB209836 - Homo sapiens mRNA for gene rich cluster, A isoform 2 variant protein.
U47929 - Human protein A alternatively spliced form 3 (A-3) mRNA, partial cds.
JD055906 - Sequence 36930 from Patent EP1572962.
JD400115 - Sequence 381139 from Patent EP1572962.
JD307929 - Sequence 288953 from Patent EP1572962.
JD080982 - Sequence 62006 from Patent EP1572962.
JD329772 - Sequence 310796 from Patent EP1572962.
JD184479 - Sequence 165503 from Patent EP1572962.
LF207392 - JP 2014500723-A/14895: Polycomb-Associated Non-Coding RNAs.
LF365846 - JP 2014500723-A/173349: Polycomb-Associated Non-Coding RNAs.
JD044923 - Sequence 25947 from Patent EP1572962.
JD252729 - Sequence 233753 from Patent EP1572962.
JD414641 - Sequence 395665 from Patent EP1572962.
MA601423 - JP 2018138019-A/173349: Polycomb-Associated Non-Coding RNAs.
MA442969 - JP 2018138019-A/14895: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000311268.1, ENST00000311268.2, ENST00000311268.3, ENST00000311268.4, ENST00000311268.5, ENST00000311268.6, ENST00000311268.7, GP162_HUMAN, GRCA, NM_019858, Q16538, Q16664, Q59EH5, Q66K56, uc317oyo.1, uc317oyo.2
UCSC ID: ENST00000311268.8_4
RefSeq Accession: NM_019858.2
Protein: Q16538 (aka GP162_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.