The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78333
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001523 retinoid metabolic process GO:0006024 glycosaminoglycan biosynthetic process GO:0006027 glycosaminoglycan catabolic process GO:0009966 regulation of signal transduction
BC039730 - Homo sapiens glypican 5, mRNA (cDNA clone MGC:47702 IMAGE:5744533), complete cds. AK312815 - Homo sapiens cDNA, FLJ93248, Homo sapiens glypican 5 (GPC5), mRNA. BC030584 - Homo sapiens cDNA clone IMAGE:4826683, containing frame-shift errors. AF001462 - Homo sapiens glypican-5 (GPC5) mRNA, complete cds. U66033 - Human glypican-5 (GPC5) mRNA, complete cds. CU691756 - Synthetic construct Homo sapiens gateway clone IMAGE:100020891 5' read GPC5 mRNA. JF432362 - Synthetic construct Homo sapiens clone IMAGE:100073555 glypican 5 (GPC5) gene, encodes complete protein. KJ891168 - Synthetic construct Homo sapiens clone ccsbBroadEn_00562 GPC5 gene, encodes complete protein. JD487385 - Sequence 468409 from Patent EP1572962. JD358700 - Sequence 339724 from Patent EP1572962. JD544477 - Sequence 525501 from Patent EP1572962. JD439411 - Sequence 420435 from Patent EP1572962. JD294896 - Sequence 275920 from Patent EP1572962. JD230630 - Sequence 211654 from Patent EP1572962. JD536878 - Sequence 517902 from Patent EP1572962. JD464297 - Sequence 445321 from Patent EP1572962. JD376870 - Sequence 357894 from Patent EP1572962. JD214516 - Sequence 195540 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P78333 (Reactome details) participates in the following event(s):
R-HSA-5362427 Hh-Np binds GPC5 R-HSA-1878002 XYLTs transfer Xyl to core protein R-HSA-1889955 B3GATs transfer GlcA to tetrasaccharide linker R-HSA-1889978 B3GALT6 transfers Gal to the tetrasaccharide linker R-HSA-2022919 EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue R-HSA-1889981 B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker R-HSA-2076419 HS6STs sulfate GlcN at C6 in heparan sulfate/heparin R-HSA-2022887 NDST1-4 N-deacetylates GlcNAc residues in heparan R-HSA-2076392 EXT1:EXT2 transfers GlcA to heparan R-HSA-2076371 GLCE epimerises more GlcA to IdoA as sulfate content rises R-HSA-2076508 HS2ST1 sulfates IdoA at C2 in heparan sulfate R-HSA-2024100 GLCE epimerises GlcA to IdoA R-HSA-2022856 EXT1:EXT2 transfers GlcNAc to heparan R-HSA-2022851 EXT1:EXT2 transfer GlcNAc to the heparan chain R-HSA-2022860 NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) R-HSA-2076383 HS3ST1 sulfates GlcN at C3 in heparan sulfate R-HSA-2076611 HS3STs sulfate GlcN at C3 in heparan sulfate R-HSA-1678694 Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) R-HSA-1667005 Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) R-HSA-5362553 NOTUM releases Hh-Np:GPC5 from the plasma membrane R-HSA-2423785 CR:atREs binds apoE and HSPG R-HSA-2429643 NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs R-HSA-2404131 LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol R-HSA-5362798 Release of Hh-Np from the secreting cell R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-2022928 HS-GAG biosynthesis R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656237 Defective EXT2 causes exostoses 2 R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-2024096 HS-GAG degradation R-HSA-5358346 Hedgehog ligand biogenesis R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism R-HSA-975634 Retinoid metabolism and transport R-HSA-5358351 Signaling by Hedgehog R-HSA-1630316 Glycosaminoglycan metabolism R-HSA-3781865 Diseases of glycosylation R-HSA-2187338 Visual phototransduction R-HSA-6806667 Metabolism of fat-soluble vitamins R-HSA-162582 Signal Transduction R-HSA-71387 Metabolism of carbohydrates R-HSA-1643685 Disease R-HSA-418594 G alpha (i) signalling events R-HSA-196854 Metabolism of vitamins and cofactors R-HSA-1430728 Metabolism R-HSA-388396 GPCR downstream signalling R-HSA-372790 Signaling by GPCR
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Common Gene Haplotype Alleles 
