Human Gene GLP1R (ENST00000373256.5_4) from GENCODE V47lift37
  Description: glucagon like peptide 1 receptor, transcript variant 3 (from RefSeq NR_136563.2)
Gencode Transcript: ENST00000373256.5_4
Gencode Gene: ENSG00000112164.6_7
Transcript (Including UTRs)
   Position: hg19 chr6:39,016,557-39,059,079 Size: 42,523 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr6:39,016,617-39,053,849 Size: 37,233 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:39,016,557-39,059,079)mRNA (may differ from genome)Protein (463 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GLP1R_HUMAN
DESCRIPTION: RecName: Full=Glucagon-like peptide 1 receptor; Short=GLP-1 receptor; Short=GLP-1-R; Short=GLP-1R; Flags: Precursor;
FUNCTION: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
SUBUNIT: May form homodimers and heterodimers with GIPR.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
PTM: N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/glp1r/";
WEB RESOURCE: Name=Wikipedia; Note=Glucagon-like peptide 1 entry; URL="http://en.wikipedia.org/wiki/Glucagon-like_peptide-1";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GLP1R
Diseases sorted by gene-association score: insulinoma (14), fasting hypoglycemia (9), pneumatosis cystoides intestinalis (6), endocrine pancreas disease (5), hyperglycemia (4), diabetes mellitus, noninsulin-dependent (3), maturity-onset diabetes of the young (2), obesity (2), glucose metabolism disease (2), diabetes mellitus, insulin-dependent (2), pancreas disease (1), acquired metabolic disease (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.90 RPKM in Pancreas
Total median expression: 7.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.8060-0.247 Picture PostScript Text
3' UTR -1730.405230-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017981 - GPCR_2-like
IPR001879 - GPCR_2_extracellular_dom
IPR003290 - GPCR_2_GLP1/glucagon_rcpt
IPR003292 - GPCR_2_GLP1_rcpt
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF02793 - Hormone receptor domain

SCOP Domains:
81321 - Family A G protein-coupled receptor-like
111418 - Hormone receptor domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3C59 - X-ray MuPIT 3C5T - X-ray MuPIT 3IOL - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P43220
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004967 glucagon receptor activity
GO:0005515 protein binding
GO:0008528 G-protein coupled peptide receptor activity
GO:0044508 glucagon-like peptide 1 receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007611 learning or memory
GO:0008016 regulation of heart contraction
GO:0019933 cAMP-mediated signaling
GO:0045777 positive regulation of blood pressure
GO:0050796 regulation of insulin secretion
GO:0071377 cellular response to glucagon stimulus
GO:1990911 response to psychosocial stress

Cellular Component:
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC112126 - Homo sapiens glucagon-like peptide 1 receptor, mRNA (cDNA clone MGC:138331 IMAGE:8327594), complete cds.
BC113493 - Homo sapiens glucagon-like peptide 1 receptor, mRNA (cDNA clone MGC:142053 IMAGE:8322545), complete cds.
U10037 - Human glucagon-like peptide-1 receptor mRNA, complete cds.
U01104 - Human glucagon-like peptide-1 receptor mRNA, complete cds.
KR138540 - Homo sapiens glucagon-like peptide-1 receptor (GLP1R) mRNA, complete cds.
L23503 - Human glucagon-like peptide-1 receptor (GLP-1) mRNA, complete cds.
BC111843 - Synthetic construct Homo sapiens clone IMAGE:40080844, MGC:133398 GLP1R protein (GLP1R) mRNA, encodes complete protein.
AB463688 - Synthetic construct DNA, clone: pF1KB7198, Homo sapiens GLP1R gene for glucagon-like peptide 1 receptor, without stop codon, in Flexi system.
U01156 - Human glucagon-like peptide-1 receptor mRNA, complete cds.
U01157 - Human glucagon-like peptide-1 receptor mRNA with CA dinucleotide repeat, complete cds.
JD477038 - Sequence 458062 from Patent EP1572962.
JD209013 - Sequence 190037 from Patent EP1572962.
JD518660 - Sequence 499684 from Patent EP1572962.
JD324933 - Sequence 305957 from Patent EP1572962.
JD097126 - Sequence 78150 from Patent EP1572962.
JD083585 - Sequence 64609 from Patent EP1572962.
JD273805 - Sequence 254829 from Patent EP1572962.
LF383484 - JP 2014500723-A/190987: Polycomb-Associated Non-Coding RNAs.
LF210774 - JP 2014500723-A/18277: Polycomb-Associated Non-Coding RNAs.
JD340482 - Sequence 321506 from Patent EP1572962.
JD263655 - Sequence 244679 from Patent EP1572962.
JD258044 - Sequence 239068 from Patent EP1572962.
JD544492 - Sequence 525516 from Patent EP1572962.
JD365932 - Sequence 346956 from Patent EP1572962.
JD365933 - Sequence 346957 from Patent EP1572962.
JD261507 - Sequence 242531 from Patent EP1572962.
JD298606 - Sequence 279630 from Patent EP1572962.
JD526458 - Sequence 507482 from Patent EP1572962.
JD266180 - Sequence 247204 from Patent EP1572962.
JD235163 - Sequence 216187 from Patent EP1572962.
JD381806 - Sequence 362830 from Patent EP1572962.
JD096155 - Sequence 77179 from Patent EP1572962.
JD442080 - Sequence 423104 from Patent EP1572962.
JD172452 - Sequence 153476 from Patent EP1572962.
JD114363 - Sequence 95387 from Patent EP1572962.
JD369994 - Sequence 351018 from Patent EP1572962.
JD119599 - Sequence 100623 from Patent EP1572962.
JD097042 - Sequence 78066 from Patent EP1572962.
JD243534 - Sequence 224558 from Patent EP1572962.
JD081071 - Sequence 62095 from Patent EP1572962.
JD337134 - Sequence 318158 from Patent EP1572962.
JD410995 - Sequence 392019 from Patent EP1572962.
JD314612 - Sequence 295636 from Patent EP1572962.
JD119727 - Sequence 100751 from Patent EP1572962.
JD189993 - Sequence 171017 from Patent EP1572962.
JD199844 - Sequence 180868 from Patent EP1572962.
JD206093 - Sequence 187117 from Patent EP1572962.
JD554714 - Sequence 535738 from Patent EP1572962.
JD253016 - Sequence 234040 from Patent EP1572962.
JD182916 - Sequence 163940 from Patent EP1572962.
LF210775 - JP 2014500723-A/18278: Polycomb-Associated Non-Coding RNAs.
LF341015 - JP 2014500723-A/148518: Polycomb-Associated Non-Coding RNAs.
JD021137 - Sequence 2161 from Patent EP1572962.
JD035244 - Sequence 16268 from Patent EP1572962.
JD029243 - Sequence 10267 from Patent EP1572962.
MA619061 - JP 2018138019-A/190987: Polycomb-Associated Non-Coding RNAs.
MA446351 - JP 2018138019-A/18277: Polycomb-Associated Non-Coding RNAs.
MA446352 - JP 2018138019-A/18278: Polycomb-Associated Non-Coding RNAs.
MA576592 - JP 2018138019-A/148518: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P43220 (Reactome details) participates in the following event(s):

R-HSA-381612 Glucagon-like Peptide-1 Receptor (GLP1R) binds Glucagon-like peptide-1
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-381706 GLP-1R:GLP-1 activates G(s)
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-422356 Regulation of insulin secretion
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-163685 Energy Metabolism
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000373256.1, ENST00000373256.2, ENST00000373256.3, ENST00000373256.4, GLP1R_HUMAN, NR_136563, P43220, Q2M229, Q99669, uc318kqa.1, uc318kqa.2
UCSC ID: ENST00000373256.5_4
RefSeq Accession: NM_002062.5
Protein: P43220 (aka GLP1R_HUMAN or GLP1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.