ID:GBRB2_HUMAN DESCRIPTION: RecName: Full=Gamma-aminobutyric acid receptor subunit beta-2; AltName: Full=GABA(A) receptor subunit beta-2; Flags: Precursor; FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. SUBUNIT: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity). SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression. SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily. WEB RESOURCE: Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http://web.expasy.org/spotlight/back_issues/sptlt056.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P47870
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006821 chloride transport GO:0007214 gamma-aminobutyric acid signaling pathway GO:0007268 chemical synaptic transmission GO:0007605 sensory perception of sound GO:0034220 ion transmembrane transport GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0048666 neuron development GO:0051932 synaptic transmission, GABAergic GO:0060119 inner ear receptor cell development GO:0060384 innervation GO:0071420 cellular response to histamine GO:0090102 cochlea development GO:1901215 negative regulation of neuron death GO:1902476 chloride transmembrane transport
A28108 - Human GABAa receptor beta-2 subunit. S67368 - GABRB2=gamma-aminobutyric acid A receptor beta 2 subunit [human, cerebellum, mRNA, 1860 nt]. AK289815 - Homo sapiens cDNA FLJ75345 complete cds, highly similar to Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 2 (GABRB2), transcript variant 2, mRNA. AK294437 - Homo sapiens cDNA FLJ53759 complete cds, highly similar to Gamma-aminobutyric-acid receptor subunit beta-2 precursor. BC099705 - Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 2, mRNA (cDNA clone MGC:119386 IMAGE:40006771), complete cds. BC099719 - Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 2, mRNA (cDNA clone MGC:119389 IMAGE:40006779), complete cds. BC105639 - Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 2, mRNA (cDNA clone MGC:119388 IMAGE:40006778), complete cds. AK289730 - Homo sapiens cDNA FLJ78552 complete cds, highly similar to Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 2 (GABRB2), transcript variant 2, mRNA. GU086163 - Homo sapiens gamma-aminobutyric acid A receptor beta 2 isoform 4 (GABRB2) mRNA, complete cds, alternatively spliced. S77553 - GABAA receptor beta 2 subunit=long form [human, brain, mRNA Partial, 1539 nt]. S77554 - GABAA receptor beta 2 subunit=short form [human, brain, mRNA Partial, 1425 nt]. KJ891213 - Synthetic construct Homo sapiens clone ccsbBroadEn_00607 GABRB2 gene, encodes complete protein. KJ896849 - Synthetic construct Homo sapiens clone ccsbBroadEn_06243 GABRB2 gene, encodes complete protein. AB384857 - Synthetic construct DNA, clone: pF1KB3797, Homo sapiens GABRB2 gene for gamma-aminobutyric-acid receptor subunit beta-2 precursor, complete cds, without stop codon, in Flexi system. GU086164 - Homo sapiens gamma-aminobutyric acid A receptor beta 2 isoform 3 (GABRB2) mRNA, complete cds, alternatively spliced. AK297609 - Homo sapiens cDNA FLJ56755 complete cds, highly similar to Gamma-aminobutyric-acid receptor subunit beta-2 precursor. BC036592 - Homo sapiens cDNA clone IMAGE:4814184. AK055125 - Homo sapiens cDNA FLJ30563 fis, clone BRAWH2004842. JD361748 - Sequence 342772 from Patent EP1572962. JD063414 - Sequence 44438 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P47870 (Reactome details) participates in the following event(s):
R-HSA-8856398 NPTN binds GABA A receptors R-HSA-975340 GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112315 Transmission across Chemical Synapses R-HSA-977441 GABA A receptor activation R-HSA-112316 Neuronal System R-HSA-977443 GABA receptor activation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
