ID:FZD1_HUMAN DESCRIPTION: RecName: Full=Frizzled-1; Short=Fz-1; Short=hFz1; AltName: Full=FzE1; Flags: Precursor; FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. DOMAIN: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity). DOMAIN: The FZ domain is involved in binding with Wnt ligands (By similarity). PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity). SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family. SIMILARITY: Contains 1 FZ (frizzled) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UP38
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_wnt-lrp6Pathway - Wnt/LRP6 Signalling h_wntPathway - WNT Signaling Pathway h_pitx2Pathway - Multi-step Regulation of Transcription by Pitx2 h_ps1Pathway - Presenilin action in Notch and Wnt signaling h_hesPathway - Segmentation Clock h_alkPathway - ALK in cardiac myocytes h_gsk3Pathway - Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
Reactome (by CSHL, EBI, and GO)
Protein Q9UP38 (Reactome details) participates in the following event(s):
R-NUL-209104 Frog CKIgamma further phosphorylates Human LRP6 in the receptor complex R-HSA-1458875 WNT binds to FZD and LRP5/6 R-HSA-3858491 WNTs bind the FZD receptor to initiate PCP pathway R-HSA-201708 Frizzled receptors bind Wnts R-HSA-5099886 WNT5A binding to FZD promotes PRICKLE1 degradation R-HSA-1504188 FZD recruits DVL to the receptor complex R-HSA-201691 Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI R-NUL-1458902 frog CK1gamma phosphorylates LRP5/6 R-HSA-201677 Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta R-HSA-3858482 DVL is recruited to the receptor R-HSA-3858480 WNT-dependent phosphorylation of DVL R-HSA-1504186 DVL recruits GSK3beta:AXIN1 to the receptor complex R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-4086400 PCP/CE pathway R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-4608870 Asymmetric localization of PCP proteins R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-195721 Signaling by WNT R-HSA-3858494 Beta-catenin independent WNT signaling R-HSA-500792 GPCR ligand binding R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
