Human Gene FOXO6 (ENST00000641094.2_4) from GENCODE V47lift37
  Description: forkhead box O6 (from RefSeq NM_001291281.3)
Gencode Transcript: ENST00000641094.2_4
Gencode Gene: ENSG00000204060.8_14
Transcript (Including UTRs)
   Position: hg19 chr1:41,827,603-41,848,353 Size: 20,751 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr1:41,827,603-41,848,353 Size: 20,751 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:41,827,603-41,848,353)mRNA (may differ from genome)Protein (492 aa)
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-  Comments and Description Text from UniProtKB
  ID: FOXO6_HUMAN
DESCRIPTION: RecName: Full=Forkhead box protein O6;
FUNCTION: Transcriptional activator (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity).
PTM: Phosphorylation of Ser-184 is be important in regulating the transacriptional activity (By similarity).
SIMILARITY: Contains 1 fork-head DNA-binding domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001766 - TF_fork_head
IPR018122 - TF_fork_head_CS
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00250 - Forkhead domain
PF16676 - Transactivation domain of FOXO protein family

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on A8MYZ6
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007613 memory
GO:0009653 anatomical structure morphogenesis
GO:0030154 cell differentiation
GO:0060999 positive regulation of dendritic spine development

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  KY243080 - Homo sapiens forkhead box protein O6 (FOXO6) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A8MYZ6, ENST00000641094.1, FOXO6_HUMAN, NM_001291281, uc328gxy.1, uc328gxy.2
UCSC ID: ENST00000641094.2_4
RefSeq Accession: NM_001291281.3
Protein: A8MYZ6 (aka FOXO6_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.