ID:FKBP8_HUMAN DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP8; Short=PPIase FKBP8; EC=5.2.1.8; AltName: Full=38 kDa FK506-binding protein; Short=38 kDa FKBP; Short=FKBP-38; Short=hFKBP38; AltName: Full=FK506-binding protein 8; Short=FKBP-8; AltName: Full=FKBPR38; AltName: Full=Rotamase; FUNCTION: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0). COFACTOR: Calcium. SUBUNIT: Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation. INTERACTION: P00533:EGFR; NbExp=3; IntAct=EBI-724839, EBI-297353; Q5T4F4:ZFYVE27; NbExp=4; IntAct=EBI-724839, EBI-3892947; SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). TISSUE SPECIFICITY: Widely expressed. Highest levels seen in the brain. MISCELLANEOUS: Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form. SIMILARITY: Contains 1 PPIase FKBP-type domain. SIMILARITY: Contains 3 TPR repeats. CAUTION: It is uncertain whether Met-1 or Met-58 is the initiator. SEQUENCE CAUTION: Sequence=AAB00102.1; Type=Miscellaneous discrepancy; Note=The first part of the cDNA maps to the same locus, but in opposite orientation; Sequence=AAH09966.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD98028.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14318
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
