Human Gene FKBP7 (ENST00000424785.7_12) from GENCODE V47lift37
  Description: FKBP prolyl isomerase 7, transcript variant 1 (from RefSeq NM_181342.3)
Gencode Transcript: ENST00000424785.7_12
Gencode Gene: ENSG00000079150.19_17
Transcript (Including UTRs)
   Position: hg19 chr2:179,328,391-179,343,327 Size: 14,937 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr2:179,330,497-179,343,226 Size: 12,730 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:179,328,391-179,343,327)mRNA (may differ from genome)Protein (222 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FKBP7_HUMAN
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP7; Short=PPIase FKBP7; EC=5.2.1.8; AltName: Full=23 kDa FK506-binding protein; Short=23 kDa FKBP; Short=FKBP-23; AltName: Full=FK506-binding protein 7; Short=FKBP-7; AltName: Full=Rotamase; Flags: Precursor;
FUNCTION: PPIases accelerate the folding of proteins during protein synthesis.
CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity).
PTM: Glycosylated (By similarity).
MISCELLANEOUS: Binds calcium (By similarity).
SIMILARITY: Contains 2 EF-hand domains.
SIMILARITY: Contains 1 PPIase FKBP-type domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FKBP7
Diseases sorted by gene-association score: osteogenesis imperfecta, type ix (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.85 RPKM in Ovary
Total median expression: 193.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -51.60101-0.511 Picture PostScript Text
3' UTR -431.002106-0.205 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd
IPR023566 - PPIase_FKBP
IPR001179 - PPIase_FKBP_dom

Pfam Domains:
PF00254 - FKBP-type peptidyl-prolyl cis-trans isomerase
PF13202 - EF hand

SCOP Domains:
47473 - EF-hand
54534 - FKBP-like

ModBase Predicted Comparative 3D Structure on Q9Y680
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding

Biological Process:
GO:0000413 protein peptidyl-prolyl isomerization
GO:0061077 chaperone-mediated protein folding

Cellular Component:
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen


-  Descriptions from all associated GenBank mRNAs
  KJ893965 - Synthetic construct Homo sapiens clone ccsbBroadEn_03359 FKBP7 gene, encodes complete protein.
AK292145 - Homo sapiens cDNA FLJ75898 complete cds, highly similar to Homo sapiens FK506 binding protein 7 (FKBP7), transcript variant 2, mRNA.
AK299215 - Homo sapiens cDNA FLJ57571 complete cds, highly similar to FK506-binding protein 7 precursor (EC 5.2.1.8).
AF092137 - Homo sapiens FK506-binding protein mRNA, complete cds.
JD063508 - Sequence 44532 from Patent EP1572962.
AY359015 - Homo sapiens clone DNA65406 FKBP (UNQ670) mRNA, complete cds.
BC009711 - Homo sapiens FK506 binding protein 7, mRNA (cDNA clone MGC:9420 IMAGE:3891173), complete cds.
AF100751 - Homo sapiens FK506-binding protein FKB23 isoform mRNA, complete cds.
LF205736 - JP 2014500723-A/13239: Polycomb-Associated Non-Coding RNAs.
AY353086 - Homo sapiens FK506-binding protein 7 (FKBP7) mRNA, complete cds; alternatively spliced.
BT007122 - Homo sapiens FK506 binding protein 7 mRNA, complete cds.
EU831809 - Synthetic construct Homo sapiens clone HAIB:100066838; DKFZo008F0521 FK506 binding protein 7 protein (FKBP7) gene, encodes complete protein.
EU831886 - Synthetic construct Homo sapiens clone HAIB:100066915; DKFZo004F0522 FK506 binding protein 7 protein (FKBP7) gene, encodes complete protein.
LF347603 - JP 2014500723-A/155106: Polycomb-Associated Non-Coding RNAs.
CU679453 - Synthetic construct Homo sapiens gateway clone IMAGE:100016802 5' read FKBP7 mRNA.
LF347604 - JP 2014500723-A/155107: Polycomb-Associated Non-Coding RNAs.
LF347605 - JP 2014500723-A/155108: Polycomb-Associated Non-Coding RNAs.
LF347606 - JP 2014500723-A/155109: Polycomb-Associated Non-Coding RNAs.
LF347608 - JP 2014500723-A/155111: Polycomb-Associated Non-Coding RNAs.
LF347610 - JP 2014500723-A/155113: Polycomb-Associated Non-Coding RNAs.
JD051364 - Sequence 32388 from Patent EP1572962.
MA583180 - JP 2018138019-A/155106: Polycomb-Associated Non-Coding RNAs.
MA583181 - JP 2018138019-A/155107: Polycomb-Associated Non-Coding RNAs.
MA583182 - JP 2018138019-A/155108: Polycomb-Associated Non-Coding RNAs.
MA583183 - JP 2018138019-A/155109: Polycomb-Associated Non-Coding RNAs.
MA583185 - JP 2018138019-A/155111: Polycomb-Associated Non-Coding RNAs.
MA583187 - JP 2018138019-A/155113: Polycomb-Associated Non-Coding RNAs.
MA441313 - JP 2018138019-A/13239: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000424785.1, ENST00000424785.2, ENST00000424785.3, ENST00000424785.4, ENST00000424785.5, ENST00000424785.6, FKBP23, FKBP7_HUMAN, NM_181342, Q4ZG70, Q6V3B2, Q86U65, Q96DA4, Q9Y680, Q9Y6B0, uc319uaz.1, uc319uaz.2, UNQ670/PRO1304
UCSC ID: ENST00000424785.7_12
RefSeq Accession: NM_181342.3
Protein: Q9Y680 (aka FKBP7_HUMAN or FKB7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.