Human Gene FKBP2 (ENST00000309366.9_4) from GENCODE V47lift37
  Description: FKBP prolyl isomerase 2, transcript variant 2 (from RefSeq NM_057092.2)
Gencode Transcript: ENST00000309366.9_4
Gencode Gene: ENSG00000173486.14_8
Transcript (Including UTRs)
   Position: hg19 chr11:64,008,567-64,011,604 Size: 3,038 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr11:64,009,860-64,011,501 Size: 1,642 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:64,008,567-64,011,604)mRNA (may differ from genome)Protein (142 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q53XJ5_HUMAN
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase;
SIMILARITY: Contains 1 PPIase FKBP-type domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FKBP2
Diseases sorted by gene-association score: osteogenesis imperfecta, type ix (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 94.68 RPKM in Pituitary
Total median expression: 1782.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.1042-0.383 Picture PostScript Text
3' UTR -22.60103-0.219 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023566 - PPIase_FKBP
IPR001179 - PPIase_FKBP_dom

Pfam Domains:
PF00254 - FKBP-type peptidyl-prolyl cis-trans isomerase

SCOP Domains:
54534 - FKBP-like

ModBase Predicted Comparative 3D Structure on Q53XJ5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0016853 isomerase activity

Biological Process:
GO:0000413 protein peptidyl-prolyl isomerization


-  Descriptions from all associated GenBank mRNAs
  BC091475 - Homo sapiens FK506 binding protein 2, 13kDa, mRNA (cDNA clone MGC:110888 IMAGE:30349098), complete cds.
GQ901006 - Homo sapiens clone HEL-T-118 epididymis secretory sperm binding protein mRNA, complete cds.
M65128 - Human rapamycin-binding protein (FKBp-13) mRNA, complete cds.
M75099 - Human rapamycin- and FK506-binding protein, complete cds.
BC003384 - Homo sapiens FK506 binding protein 2, 13kDa, mRNA (cDNA clone MGC:5177 IMAGE:3445148), complete cds.
AB463640 - Synthetic construct DNA, clone: pF1KB6742, Homo sapiens FKBP2 gene for FK506 binding protein 2, without stop codon, in Flexi system.
KJ891177 - Synthetic construct Homo sapiens clone ccsbBroadEn_00571 FKBP2 gene, encodes complete protein.
CR407636 - Homo sapiens full open reading frame cDNA clone RZPDo834C127D for gene FKBP2, FK506 binding protein 2, 13kDa complete cds, without stopcodon.
DQ894131 - Synthetic construct Homo sapiens clone IMAGE:100008591; FLH168018.01L; RZPDo839B0291D FK506 binding protein 2, 13kDa (FKBP2) gene, encodes complete protein.
BT009861 - Homo sapiens FK506 binding protein 2, 13kDa mRNA, complete cds.
JD382374 - Sequence 363398 from Patent EP1572962.
JD481757 - Sequence 462781 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000309366.1, ENST00000309366.2, ENST00000309366.3, ENST00000309366.4, ENST00000309366.5, ENST00000309366.6, ENST00000309366.7, ENST00000309366.8, FKBP2 , hCG_21364 , NM_057092, Q53XJ5, Q53XJ5_HUMAN, uc317ond.1, uc317ond.2
UCSC ID: ENST00000309366.9_4
RefSeq Accession: NM_004470.4
Protein: Q53XJ5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.