ID:FKB10_HUMAN DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP10; Short=PPIase FKBP10; EC=5.2.1.8; AltName: Full=65 kDa FK506-binding protein; Short=65 kDa FKBP; Short=FKBP-65; AltName: Full=FK506-binding protein 10; Short=FKBP-10; AltName: Full=Immunophilin FKBP65; AltName: Full=Rotamase; Flags: Precursor; FUNCTION: PPIases accelerate the folding of proteins during protein synthesis. CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0). ENZYME REGULATION: Inhibited by both FK506 and rapamycin, but not by cyclosporin A (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity). PTM: Glycosylated and phosphorylated (By similarity). DISEASE: Defects in FKBP10 are the cause of osteogenesis imperfecta type 6 (OI6) [MIM:610968]. OI6 is a moderate to severe, autosomal recessive form of osteogenesis imperfecta characterized by increased serum alkaline phosphatase levels and bone histology exhibiting a fish scale-like lamellar pattern. Osteogenesis imperfecta defines a group of connective tissue disorders characterized by bone fragility and low bone mass. SIMILARITY: Contains 2 EF-hand domains. SIMILARITY: Contains 4 PPIase FKBP-type domains. SEQUENCE CAUTION: Sequence=BAB15220.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD97695.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; WEB RESOURCE: Name=Osteogenesis imperfecta variant database; Note=Peptidyl-prolyl cis-trans isomerase FKBP10; URL="http://oi.gene.le.ac.uk/home.php?select_db=FKBP10";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96AY3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
