ID:FGF19_HUMAN DESCRIPTION: RecName: Full=Fibroblast growth factor 19; Short=FGF-19; Flags: Precursor; FUNCTION: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. SUBUNIT: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with KL; this interaction is direct. Interacts with KLB; this interaction is direct. Interacts with FGFR4 in the presence of heparin, KL or KLB. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in fetal brain, cartilage, retina, and adult gall bladder. INDUCTION: Induced by the bile acids receptor NR1H4 that binds and activates a NR1H4-responsive element within intron 2. MISCELLANEOUS: Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for FGFR4. SIMILARITY: Belongs to the heparin-binding growth factors family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95750
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0001755 neural crest cell migration GO:0001934 positive regulation of protein phosphorylation GO:0007399 nervous system development GO:0007507 heart development GO:0008284 positive regulation of cell proliferation GO:0008543 fibroblast growth factor receptor signaling pathway GO:0010469 regulation of receptor activity GO:0010629 negative regulation of gene expression GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process GO:0046326 positive regulation of glucose import GO:0046330 positive regulation of JNK cascade GO:0046854 phosphatidylinositol phosphorylation GO:0051897 positive regulation of protein kinase B signaling GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070858 negative regulation of bile acid biosynthetic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
