Human Gene FGF18 (ENST00000274625.6_4) from GENCODE V47lift37
  Description: fibroblast growth factor 18 (from RefSeq NM_003862.3)
Gencode Transcript: ENST00000274625.6_4
Gencode Gene: ENSG00000156427.8_7
Transcript (Including UTRs)
   Position: hg19 chr5:170,846,651-170,884,630 Size: 37,980 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr5:170,847,204-170,883,809 Size: 36,606 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:170,846,651-170,884,630)mRNA (may differ from genome)Protein (207 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FGF18_HUMAN
DESCRIPTION: RecName: Full=Fibroblast growth factor 18; Short=FGF-18; AltName: Full=zFGF5; Flags: Precursor;
FUNCTION: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.
SUBUNIT: Interacts with FGFR3 and FGFR4.
SUBCELLULAR LOCATION: Secreted (By similarity).
SIMILARITY: Belongs to the heparin-binding growth factors family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FGF18
Diseases sorted by gene-association score: congenital diaphragmatic hernia (3), endometrial cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.07 RPKM in Heart - Left Ventricle
Total median expression: 34.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -311.90553-0.564 Picture PostScript Text
3' UTR -182.30821-0.222 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008996 - Cytokine_IL1-like
IPR002348 - IL1_HBGF

Pfam Domains:
PF00167 - Fibroblast growth factor

SCOP Domains:
50353 - Cytokine
50405 - Actin-crosslinking proteins

ModBase Predicted Comparative 3D Structure on O76093
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004713 protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005105 type 1 fibroblast growth factor receptor binding
GO:0005111 type 2 fibroblast growth factor receptor binding
GO:0008083 growth factor activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Biological Process:
GO:0000165 MAPK cascade
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001957 intramembranous ossification
GO:0001958 endochondral ossification
GO:0002063 chondrocyte development
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009653 anatomical structure morphogenesis
GO:0010469 regulation of receptor activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030324 lung development
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032332 positive regulation of chondrocyte differentiation
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0043406 positive regulation of MAP kinase activity
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0046854 phosphatidylinositol phosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:0001936 regulation of endothelial cell proliferation
GO:1903670 regulation of sprouting angiogenesis

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  AY358811 - Homo sapiens DNA27863 FGF18 (UNQ420) mRNA, partial cds.
AF075292 - Homo sapiens fibroblast growth factor 18 (FGF18) mRNA, complete cds.
JD476236 - Sequence 457260 from Patent EP1572962.
JD442094 - Sequence 423118 from Patent EP1572962.
JD150934 - Sequence 131958 from Patent EP1572962.
JD339820 - Sequence 320844 from Patent EP1572962.
BC006245 - Homo sapiens fibroblast growth factor 18, mRNA (cDNA clone MGC:10529 IMAGE:3948893), complete cds.
JD370404 - Sequence 351428 from Patent EP1572962.
JD068243 - Sequence 49267 from Patent EP1572962.
JD460807 - Sequence 441831 from Patent EP1572962.
JD186849 - Sequence 167873 from Patent EP1572962.
JD186852 - Sequence 167876 from Patent EP1572962.
JC506688 - Sequence 56 from Patent EP2733220.
JC737800 - Sequence 56 from Patent WO2014075939.
JC506666 - Sequence 34 from Patent EP2733220.
JC737778 - Sequence 34 from Patent WO2014075939.
JC506661 - Sequence 29 from Patent EP2733220.
JC737773 - Sequence 29 from Patent WO2014075939.
JC506674 - Sequence 42 from Patent EP2733220.
JC737786 - Sequence 42 from Patent WO2014075939.
JC506671 - Sequence 39 from Patent EP2733220.
JC737783 - Sequence 39 from Patent WO2014075939.
JD462654 - Sequence 443678 from Patent EP1572962.
JD146080 - Sequence 127104 from Patent EP1572962.
AB528345 - Synthetic construct DNA, clone: pF1KE0204, Homo sapiens FGF18 gene for fibroblast growth factor 18, without stop codon, in Flexi system.
AM393798 - Synthetic construct Homo sapiens clone IMAGE:100002522 for hypothetical protein (FGF18 gene).
DQ895983 - Synthetic construct Homo sapiens clone IMAGE:100010443; FLH189229.01L; RZPDo839C1264D fibroblast growth factor 18 (FGF18) gene, encodes complete protein.
AB007422 - Homo sapiens mRNA for fibroblast growth factor (FGF-18), complete cds.
BT019570 - Homo sapiens fibroblast growth factor 18 mRNA, complete cds.
BT019571 - Homo sapiens fibroblast growth factor 18 mRNA, complete cds.
DQ892736 - Synthetic construct clone IMAGE:100005366; FLH189233.01X; RZPDo839C1274D fibroblast growth factor 18 (FGF18) gene, encodes complete protein.
AF211188 - Homo sapiens zFGF5 mRNA, complete cds.
JD121263 - Sequence 102287 from Patent EP1572962.
JD129068 - Sequence 110092 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O76093 (Reactome details) participates in the following event(s):

R-HSA-190261 FGFR3c binds to FGF
R-HSA-2012074 FGFR3c P250R mutant binds to ligand with enhanced affinity
R-HSA-190265 FGFR4 binds to FGF
R-HSA-190263 FGFR3b binds to FGF
R-HSA-5654511 FGFRL1 dimer binds FGFs
R-HSA-190388 Autocatalytic phosphorylation of FGFR3c
R-HSA-2012073 Autocatalytic phosphorylation of FGFR3c P250R mutant
R-HSA-2033472 FGFR2c mutants bind an expanded range of ligands
R-HSA-190326 Autocatalytic phosphorylation of FGFR4
R-HSA-190385 Autocatalytic phosphorylation of FGFR3b
R-HSA-5654224 Activated FGFR3 binds PLCG1
R-HSA-5654409 Activated FGFR3 binds FRS2
R-HSA-5654623 Activated FGFR3 binds FRS3
R-HSA-5654625 Activated FGFR3 binds SHC1
R-HSA-5654148 p-4Y-PLCG1 dissociates from activated FGFR3
R-HSA-2077420 FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
R-HSA-5655244 Activated FGFR3 mutants bind PLCG1
R-HSA-5655262 Activated FGFR3 mutants bind FRS2
R-HSA-5655247 p-4Y-PLCG1 dissociates from activated FGFR3 mutants
R-HSA-190413 Autocatalytic phosphorylation of FGFR2c
R-HSA-2033486 Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
R-HSA-5654163 Activated FGFR4 binds PLCG1
R-HSA-5654422 Activated FGFR4 binds FRS2
R-HSA-5654425 Activated FGFR4 binds SHC1
R-HSA-5654651 Activated FGFR4 binds FRS3
R-HSA-5654169 p-4Y-PLCG1 dissociates from activated FGFR4
R-HSA-5654222 Activated FGFR3 phosphorylates PLCG1
R-HSA-5654408 Activated FGFR3 phosphorylates FRS2
R-HSA-5654565 Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
R-HSA-5654637 Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654628 Activated FGFR3 phosphorylates FRS3
R-HSA-5654634 Activated FGFR3 phosphorylates SHC1
R-HSA-5654646 Activated FGFR3:p-SHC1 binds GRB2:SOS1
R-HSA-5655295 Activated FGFR3 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655315 Activated FGFR3 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655270 Activated FGFR3 mutants phosphorylate FRS2
R-HSA-5655243 Activated FGFR3 mutants phosphorylate PLCG1
R-HSA-5654159 Activated FGFR2 binds PLCG1
R-HSA-5654399 Activated FGFR2 binds FRS2
R-HSA-5654404 Activated FGFR2 binds SHC1
R-HSA-5654603 Activated FGFR2 binds FRS3
R-HSA-5654157 p-4Y-PLCG1 dissociates from activated FGFR2
R-HSA-2077424 Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
R-HSA-5655339 Activated FGFR2 mutants bind FRS2
R-HSA-5655343 Activated FGFR2 mutants bind PLCG1
R-HSA-5654748 p-4Y-PLCG1 dissociates from activated FGFR2 mutants
R-HSA-5654151 Activated FGFR4 phosphorylates PLCG1
R-HSA-5654418 Activated FGFR4 phosphorylates FRS2
R-HSA-5654566 Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
R-HSA-5654659 Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654653 Activated FGFR4 phosphorylates FRS3
R-HSA-5654428 Activated FGFR4 phosphorylates SHC1
R-HSA-5654423 Activated FGFR4:p-SHC1 binds GRB2:SOS1
R-HSA-5654641 Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654730 p-CBL:GRB2 binds p-FRS2:activated FGFR3
R-HSA-5654640 Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654416 Activated FGFR3:pFRS binds GRB2:SOS1
R-HSA-5654633 Activated FGFR3:p-FRS bind to PPTN11
R-HSA-5655285 Activated FGFR3 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654147 Activated FGFR2 phosphorylates PLCG1
R-HSA-5654397 Activated FGFR2 phosphorylates FRS2
R-HSA-5654562 Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
R-HSA-5654612 Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654605 Activated FGFR2 phosphorylates FRS3
R-HSA-5654407 Activated FGFR2 phosphorylates SHC1
R-HSA-5654406 Activated FGFR2:p-SHC1 binds GRB2:SOS1
R-HSA-5655301 Activated FGFR2 mutants phosphorylate PLCG1
R-HSA-5655233 Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655320 Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655268 Activated FGFR2 mutants phosphorylate FRS2
R-HSA-5654662 Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654667 Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654734 p-CBL:GRB2 binds p-FRS2:activated FGFR4
R-HSA-5654658 Activated FGFR4:p-FRS bind to PPTN11
R-HSA-5654664 Activated FGFR4:p-FRS binds GRB2:SOS1
R-HSA-5654643 Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654679 CBL ubiquitinates FRS2 and FGFR3
R-HSA-5654631 Activated FGFR3 phosphorylates PPTN11
R-HSA-5654647 Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655277 Activated FGFR3 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654620 Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654729 p-CBL:GRB2 binds p-FRS2:activated FGFR2
R-HSA-5654614 Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654608 Activated FGFR2:p-FRS bind to PPTN11
R-HSA-5654615 Activated FGFR2:pFRS binds GRB2:SOS1
R-HSA-5655245 Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654669 Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
R-HSA-5654684 CBL ubiquitinates FRS2 and FGFR4
R-HSA-5654655 Activated FGFR4 phosphorylates PPTN11
R-HSA-5654426 Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654705 FGFR3-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654413 Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-5655289 Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654622 Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654677 CBL ubiquitinates FRS2 and FGFR2
R-HSA-5654607 Activated FGFR2 phosphorylates PPTN11
R-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655241 Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654717 FGFR4-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654663 Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654709 FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-5654701 FGFR2-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654618 Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655323 Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654714 FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-109699 PI3K-containing complexes phosphorylate PIP2 to PIP3
R-HSA-5654697 FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190371 FGFR3b ligand binding and activation
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-190239 FGFR3 ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-190241 FGFR2 ligand binding and activation
R-HSA-5654743 Signaling by FGFR4
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654227 Phospholipase C-mediated cascade; FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-5654741 Signaling by FGFR3
R-HSA-1839126 FGFR2 mutant receptor activation
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-190236 Signaling by FGFR
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654708 Downstream signaling of activated FGFR3
R-HSA-5655332 Signaling by FGFR3 in disease
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654716 Downstream signaling of activated FGFR4
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654696 Downstream signaling of activated FGFR2
R-HSA-162582 Signal Transduction
R-HSA-5663202 Diseases of signal transduction
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-1643685 Disease
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-109704 PI3K Cascade
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5683057 MAPK family signaling cascades
R-HSA-112399 IRS-mediated signalling
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-74752 Signaling by Insulin receptor
R-HSA-2428924 IGF1R signaling cascade
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

-  Other Names for This Gene
  Alternate Gene Symbols: D3DQL7, ENST00000274625.1, ENST00000274625.2, ENST00000274625.3, ENST00000274625.4, ENST00000274625.5, FGF18_HUMAN, NM_003862, O76093, Q6UWF1, uc317jfw.1, uc317jfw.2, UNQ420/PRO856
UCSC ID: ENST00000274625.6_4
RefSeq Accession: NM_003862.3
Protein: O76093 (aka FGF18_HUMAN or FGFI_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.