Human Gene FGF11 (ENST00000293829.9_4) from GENCODE V47lift37
  Description: fibroblast growth factor 11, transcript variant 1 (from RefSeq NM_004112.4)
Gencode Transcript: ENST00000293829.9_4
Gencode Gene: ENSG00000161958.11_8
Transcript (Including UTRs)
   Position: hg19 chr17:7,342,831-7,348,256 Size: 5,426 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr17:7,342,940-7,346,465 Size: 3,526 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:7,342,831-7,348,256)mRNA (may differ from genome)Protein (225 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FGF11_HUMAN
DESCRIPTION: RecName: Full=Fibroblast growth factor 11; Short=FGF-11; AltName: Full=Fibroblast growth factor homologous factor 3; Short=FHF-3;
FUNCTION: Probably involved in nervous system development and function.
TISSUE SPECIFICITY: Nervous system.
SIMILARITY: Belongs to the heparin-binding growth factors family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fgf11/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.05 RPKM in Adrenal Gland
Total median expression: 117.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.30109-0.526 Picture PostScript Text
3' UTR -609.301791-0.340 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008996 - Cytokine_IL1-like
IPR002209 - GF_heparin-bd
IPR002348 - IL1_HBGF

Pfam Domains:
PF00167 - Fibroblast growth factor

SCOP Domains:
50353 - Cytokine
50370 - Ricin B-like lectins
50405 - Actin-crosslinking proteins

ModBase Predicted Comparative 3D Structure on Q92914
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008083 growth factor activity

Biological Process:
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
GO:0010469 regulation of receptor activity

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  AK122636 - Homo sapiens cDNA FLJ16061 fis, clone TESTI2042750, moderately similar to FIBROBLAST GROWTH FACTOR-11.
AK308812 - Homo sapiens cDNA, FLJ98853.
AK308477 - Homo sapiens cDNA, FLJ98518.
BC108265 - Homo sapiens fibroblast growth factor 11, mRNA (cDNA clone MGC:102953 IMAGE:4804221), complete cds.
LF212403 - JP 2014500723-A/19906: Polycomb-Associated Non-Coding RNAs.
BC032502 - Homo sapiens fibroblast growth factor 11, mRNA (cDNA clone MGC:45269 IMAGE:5242670), complete cds.
AB209390 - Homo sapiens mRNA for fibroblast growth factor 11 variant protein.
AB590462 - Synthetic construct DNA, clone: pFN21AE1719, Homo sapiens FGF11 gene for fibroblast growth factor 11, without stop codon, in Flexi system.
KJ891164 - Synthetic construct Homo sapiens clone ccsbBroadEn_00558 FGF11 gene, encodes complete protein.
AY049782 - Homo sapiens fibroblast growth factor 11 (FGF11) mRNA, complete cds.
U66199 - Human fibroblast growth factor homologous factor 3 (FHF-3) mRNA, complete cds.
BC037421 - Homo sapiens fibroblast growth factor 11, mRNA (cDNA clone IMAGE:5497572), with apparent retained intron.
AK293131 - Homo sapiens cDNA FLJ55834 complete cds, highly similar to Fibroblast growth factor 11.
AK311269 - Homo sapiens cDNA, FLJ18311.
Z70275 - H.sapiens mRNA for fibroblast growth factor 11 (partial).
MA447980 - JP 2018138019-A/19906: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000293829.1, ENST00000293829.2, ENST00000293829.3, ENST00000293829.4, ENST00000293829.5, ENST00000293829.6, ENST00000293829.7, ENST00000293829.8, FGF11_HUMAN, FHF3, NM_004112, Q2YDX8, Q92914, uc317lex.1, uc317lex.2
UCSC ID: ENST00000293829.9_4
RefSeq Accession: NM_004112.4
Protein: Q92914 (aka FGF11_HUMAN or FGFB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.