Human Gene FASTKD5 (ENST00000380266.4_7) from GENCODE V47lift37
  Description: FAST kinase domains 5 (from RefSeq NM_021826.5)
Gencode Transcript: ENST00000380266.4_7
Gencode Gene: ENSG00000215251.5_11
Transcript (Including UTRs)
   Position: hg19 chr20:3,127,165-3,140,511 Size: 13,347 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr20:3,127,422-3,129,716 Size: 2,295 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:3,127,165-3,140,511)mRNA (may differ from genome)Protein (764 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FAKD5_HUMAN
DESCRIPTION: RecName: Full=FAST kinase domain-containing protein 5;
SIMILARITY: Belongs to the FAST kinase family.
SIMILARITY: Contains 1 RAP domain.
SEQUENCE CAUTION: Sequence=BAB15696.1; Type=Frameshift; Positions=662; Sequence=BAB47421.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.33 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 294.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -90.70290-0.313 Picture PostScript Text
3' UTR -53.50257-0.208 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013579 - FAST_2
IPR010622 - FAST_Leu-rich
IPR013584 - RAP

Pfam Domains:
PF06743 - FAST kinase-like protein, subdomain 1
PF08368 - FAST kinase-like protein, subdomain 2
PF08373 - RAP domain

ModBase Predicted Comparative 3D Structure on Q7L8L6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0019843 rRNA binding

Biological Process:
GO:0000963 mitochondrial RNA processing
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0045333 cellular respiration

Cellular Component:
GO:0005739 mitochondrion
GO:0035770 ribonucleoprotein granule
GO:0042645 mitochondrial nucleoid


-  Descriptions from all associated GenBank mRNAs
  AB020667 - Homo sapiens mRNA for KIAA0860 protein, partial cds.
BC000515 - Homo sapiens U-box domain containing 5, mRNA (cDNA clone MGC:8549 IMAGE:2822816), complete cds.
BC064544 - Homo sapiens U-box domain containing 5, mRNA (cDNA clone IMAGE:5734178), containing frame-shift errors.
AK222876 - Homo sapiens mRNA for ubiquitin conjugating enzyme 7 interacting protein 5 isoform a variant, clone: HEP15307.
AK022444 - Homo sapiens cDNA FLJ12382 fis, clone MAMMA1002585, highly similar to Homo sapiens U-box domain containing 5 (UBOX5), transcript variant 2, mRNA.
BC046122 - Homo sapiens U-box domain containing 5, mRNA (cDNA clone MGC:57578 IMAGE:5554044), complete cds.
AK222570 - Homo sapiens mRNA for ubiquitin conjugating enzyme 7 interacting protein 5 isoform b variant, clone: CAS02238.
AK027215 - Homo sapiens cDNA: FLJ23562 fis, clone LNG10072.
BC011856 - Homo sapiens FAST kinase domains 5, mRNA (cDNA clone MGC:19878 IMAGE:4298806), complete cds.
BC007413 - Homo sapiens FAST kinase domains 5, mRNA (cDNA clone MGC:2564 IMAGE:3010170), complete cds.
AB058695 - Homo sapiens KIAA1792 mRNA for KIAA1792 protein.
AK023211 - Homo sapiens cDNA FLJ13149 fis, clone NT2RP3003344.
JD348616 - Sequence 329640 from Patent EP1572962.
AK301748 - Homo sapiens cDNA FLJ58294 complete cds.
EU831430 - Synthetic construct Homo sapiens clone HAIB:100066459; DKFZo008C0617 FAST kinase domains 5 protein (FASTKD5) gene, encodes complete protein.
KJ899403 - Synthetic construct Homo sapiens clone ccsbBroadEn_08797 FASTKD5 gene, encodes complete protein.
KJ905519 - Synthetic construct Homo sapiens clone ccsbBroadEn_15127 FASTKD5 gene, encodes complete protein.
AB384294 - Synthetic construct DNA, clone: pF1KSDA1792, Homo sapiens FASTKD5 gene for FAST kinase domain-containing protein 5, complete cds, without stop codon, in Flexi system.
KJ906288 - Synthetic construct Homo sapiens clone ccsbBroadEn_15958 FASTKD5 gene, encodes complete protein.
CU680080 - Synthetic construct Homo sapiens gateway clone IMAGE:100017487 5' read FASTKD5 mRNA.
JD315235 - Sequence 296259 from Patent EP1572962.
JD371617 - Sequence 352641 from Patent EP1572962.
JD182318 - Sequence 163342 from Patent EP1572962.
JD493124 - Sequence 474148 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000380266.1, ENST00000380266.2, ENST00000380266.3, FAKD5_HUMAN, KIAA1792, NM_021826, Q7L8L6, Q96JN3, Q9H5D1, Q9H8Y3, uc318pmg.1, uc318pmg.2
UCSC ID: ENST00000380266.4_7
RefSeq Accession: NM_021826.5
Protein: Q7L8L6 (aka FAKD5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.