Human Gene FAS (ENST00000355740.2) from GENCODE V47lift37
  Description: Fas cell surface death receptor (from HGNC FAS)
Gencode Transcript: ENST00000355740.2
Gencode Gene: ENSG00000026103.15
Transcript (Including UTRs)
   Position: hg19 chr10:90,750,414-90,775,542 Size: 25,129 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr10:90,750,634-90,774,207 Size: 23,574 Coding Exon Count: 9 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:90,750,414-90,775,542)mRNA (may differ from genome)Protein (335 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FAS
Diseases sorted by gene-association score: autoimmune lymphoproliferative syndrome* (1174), fas-related autoimmune lymphoproliferative syndrome* (200), lymphoproliferative syndrome (42), silicosis (20), dianzani autoimmune lymphoproliferative disease (19), oligoarticular juvenile idiopathic arthritis* (18), caplan's syndrome (15), lymphopenia (15), vogt-koyanagi-harada disease* (15), persistent polyclonal b-cell lymphocytosis (13), lymphocytic gastritis (12), viral hepatitis (11), type ii mixed cryoglobulinemia (10), acid sphingomyelinase deficiency (10), cowpox (10), lymphoma, non-hodgkin (9), lymphomatoid papulosis (9), hypersensitivity syndrome, carbamazepine-induced (9), burn scar (9), keloids (9), hashimoto thyroiditis (9), rheumatoid factor-negative juvenile idiopathic arthritis* (8), kashin-beck disease (8), ewing's family of tumors (8), thyroid lymphoma (8), panniculitis (7), behcet syndrome* (7), cartilage-hair hypoplasia (7), lattice corneal dystrophy (7), pediatric osteosarcoma (7), autoimmune hepatitis (6), adult t-cell leukemia (6), syphilis (6), acute myocarditis (6), epithelial basement membrane dystrophy (6), epithelial-stromal tgfbi dystrophy (6), pneumoconiosis (6), hodgkin lymphoma (5), hypersensitivity reaction type iv disease (5), central nervous system tuberculosis (5), squamous cell carcinoma (5), nodular goiter (5), epstein-barr virus-associated gastric carcinoma (5), liver disease (5), brain glioma (5), stevens-johnson syndrome/toxic epidermal necrolysis (5), malignant glioma (4), burkitt lymphoma (4), aplastic anemia (4), lung cancer (3), fatty liver disease (3), colorectal cancer (3), stomach cancer (3), hypersensitivity reaction type ii disease (3), myelodysplastic syndrome (3), hemophagocytic lymphohistiocytosis (2), chronic lymphocytic leukemia (2), hepatocellular carcinoma (2), common variable immunodeficiency (2), prostate cancer (2), renal cell carcinoma (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.67 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 406.16 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -90.40220-0.411 Picture PostScript Text
3' UTR -277.901335-0.208 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000488 - Death
IPR011029 - DEATH-like

Pfam Domains:
PF00020 - TNFR/NGFR cysteine-rich region
PF00531 - Death domain

SCOP Domains:
47986 - DEATH domain
57586 - TNF receptor-like

ModBase Predicted Comparative 3D Structure on Q8IUB7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004888 transmembrane signaling receptor activity

Biological Process:
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0007165 signal transduction

Cellular Component:
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AB209361 - Homo sapiens mRNA for tumor necrosis factor receptor superfamily, member 6 isoform 1 precursor variant protein.
AB463626 - Synthetic construct DNA, clone: pF1KB6517, Homo sapiens FAS gene for Fas, without stop codon, in Flexi system.
HI635183 - Sequence 41030 from Patent EP2242854.
HI635184 - Sequence 41031 from Patent EP2242854.
HI635185 - Sequence 41032 from Patent EP2242854.
HI635186 - Sequence 41033 from Patent EP2242854.
HI635187 - Sequence 41034 from Patent EP2242854.
HI635188 - Sequence 41035 from Patent EP2242854.
HI635189 - Sequence 41036 from Patent EP2242854.
HI635190 - Sequence 41037 from Patent EP2242854.
HV708938 - JP 2012506450-A/36: Methods for treating eye disorders.
HV708939 - JP 2012506450-A/37: Methods for treating eye disorders.
HV708940 - JP 2012506450-A/38: Methods for treating eye disorders.
HV708941 - JP 2012506450-A/39: Methods for treating eye disorders.
HV708942 - JP 2012506450-A/40: Methods for treating eye disorders.
HV708943 - JP 2012506450-A/41: Methods for treating eye disorders.
HV708944 - JP 2012506450-A/42: Methods for treating eye disorders.
HV708945 - JP 2012506450-A/43: Methods for treating eye disorders.
JA482171 - Sequence 154 from Patent WO2011072091.
JA482172 - Sequence 155 from Patent WO2011072091.
JA482173 - Sequence 156 from Patent WO2011072091.
JA482174 - Sequence 157 from Patent WO2011072091.
JA482175 - Sequence 158 from Patent WO2011072091.
JA482176 - Sequence 159 from Patent WO2011072091.
JA482177 - Sequence 160 from Patent WO2011072091.
JE980463 - Sequence 154 from Patent EP2862929.
JE980464 - Sequence 155 from Patent EP2862929.
JE980465 - Sequence 156 from Patent EP2862929.
JE980466 - Sequence 157 from Patent EP2862929.
JE980467 - Sequence 158 from Patent EP2862929.
JE980468 - Sequence 159 from Patent EP2862929.
JE980469 - Sequence 160 from Patent EP2862929.
KJ958564 - Homo sapiens mutant tumor necrosis receptor superfamily member 6 mRNA, complete cds.
KM114217 - Homo sapiens FAS mRNA, complete cds.
BC012479 - Homo sapiens Fas (TNF receptor superfamily, member 6), mRNA (cDNA clone MGC:21432 IMAGE:4514272), complete cds.
AK290978 - Homo sapiens cDNA FLJ77106 complete cds, highly similar to Homo sapiens Fas (TNF receptor superfamily, member 6) (FAS), transcript variant 1, mRNA.
JD406618 - Sequence 387642 from Patent EP1572962.
X63717 - H.sapiens mRNA for APO-1 cell surface antigen.
JD360773 - Sequence 341797 from Patent EP1572962.
AY495076 - Homo sapiens Fas AMA mRNA, complete cds.
EU481974 - Homo sapiens FAS 827dupA variant (FAS) mRNA, complete cds.
E05110 - cDNA encoding human Fas antigen.
E09121 - cDNA encoding hFas.
M67454 - Human Fas antigen (fas) mRNA, complete cds.
JD134238 - Sequence 115262 from Patent EP1572962.
JD401341 - Sequence 382365 from Patent EP1572962.
JD206455 - Sequence 187479 from Patent EP1572962.
X83490 - H.sapiens mRNA for Fas/Apo-1 (clone pCRTM11-Fasdelta(3,4)).
X83491 - H.sapiens mRNA for Fas/Apo-1 (clone pCRTM11-Fasdelta(3,4,6)).
X83492 - H.sapiens mRNA for Fas/Apo-1 (clone pCRTM11-Fasdelta(4,7)).
X83493 - H.sapiens mRNA for Fas/Apo-1 (clone pCRTM11-FasdeltaTM).
E10172 - cDNA encoding human Fas antigen variant.
DQ894675 - Synthetic construct Homo sapiens clone IMAGE:100009135; FLH177405.01L; RZPDo839H06123D Fas (TNF receptor superfamily, member 6) (FAS) gene, encodes complete protein.
KJ890693 - Synthetic construct Homo sapiens clone ccsbBroadEn_00087 FAS gene, encodes complete protein.
KR709616 - Synthetic construct Homo sapiens clone CCSBHm_00004095 FAS (FAS) mRNA, encodes complete protein.
KR709617 - Synthetic construct Homo sapiens clone CCSBHm_00004098 FAS (FAS) mRNA, encodes complete protein.
KR709618 - Synthetic construct Homo sapiens clone CCSBHm_00004103 FAS (FAS) mRNA, encodes complete protein.
KR709619 - Synthetic construct Homo sapiens clone CCSBHm_00004124 FAS (FAS) mRNA, encodes complete protein.
X89101 - H.sapiens mRNA for Fas (Apo-1, CD95).
E09122 - cDNA encoding hFas.EXT.
CR450307 - Homo sapiens full open reading frame cDNA clone RZPDo834E051D for gene TNFRSF6, tumor necrosis factor receptor superfamily, member 6; complete cds; without stopcodon.
E05336 - DNA encoding human Fas protein.
FJ200481 - Homo sapiens FAS receptor variant 9 mRNA, complete cds.
FJ373045 - Homo sapiens FAS variant (FAS) mRNA, complete cds.
FJ373046 - Homo sapiens FAS variant (FAS) mRNA, complete cds.
FM246457 - Homo sapiens TNFRSF6 pseudogene mRNA, patient BHR.
FM246458 - Homo sapiens mRNA for tumor necrosis factor receptor superfamily member 6 (TNFRSF6 gene), patient MRR.
FM246459 - Homo sapiens mRNA for truncated tumor necrosis factor receptor superfamily member 6 protein (TNFRSF6 gene), patient JBB.
Z47993 - H.sapiens FASTM Del mRNA.
Z47994 - H.sapiens FAS Del 2 mRNA.
Z47995 - H.sapiens FAS Del3 mRNA.
Z66556 - H.sapiens FASExo8Del mRNA.
Z70519 - H.sapiens FAS/Apo 1 mRNA for FAS soluble protein (clone FAS Exo4Del).
Z70520 - H.sapiens FAS/Apo 1 mRNA for FAS soluble protein (clone FAS Exo4,6Del).
AK311424 - Homo sapiens cDNA, FLJ18466.
AK311499 - Homo sapiens cDNA, FLJ18541.
AK311164 - Homo sapiens cDNA, FLJ18206.
S78781 - Delta Fas/APO-1/CD95=TNF-like apoptosis-inducing receptor {deletion junction} [human, LM2-p53 osteosarcoma cells, mRNA Partial Mutant, 58 nt].
JD171785 - Sequence 152809 from Patent EP1572962.
JD048531 - Sequence 29555 from Patent EP1572962.
JD380485 - Sequence 361509 from Patent EP1572962.
JD042981 - Sequence 24005 from Patent EP1572962.
JD510204 - Sequence 491228 from Patent EP1572962.
JD059092 - Sequence 40116 from Patent EP1572962.
JD563180 - Sequence 544204 from Patent EP1572962.
JD065408 - Sequence 46432 from Patent EP1572962.
JD313960 - Sequence 294984 from Patent EP1572962.
JD308682 - Sequence 289706 from Patent EP1572962.
JD041498 - Sequence 22522 from Patent EP1572962.
JD528573 - Sequence 509597 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_hsp27Pathway - Stress Induction of HSP Regulation
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation
h_bbcellPathway - Bystander B Cell Activation
h_fasPathway - FAS signaling pathway ( CD95 )
h_keratinocytePathway - Keratinocyte Differentiation
h_ctlPathway - CTL mediated immune response against target cells
h_pmlPathway - Regulation of transcriptional activity by PML
h_asbcellPathway - Antigen Dependent B Cell Activation
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF
h_tcapoptosisPathway - HIV Induced T Cell Apoptosis

-  Other Names for This Gene
  Alternate Gene Symbols: CD95 , ENST00000355740.1, NM_152872, Q8IUB7, Q8IUB7_HUMAN, uc317zfs.1
UCSC ID: ENST00000355740.2
RefSeq Accession: NM_000043.6
Protein: Q8IUB7

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene FAS:
alps (Autoimmune Lymphoproliferative Syndrome)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.