Human Gene EXOC3 (ENST00000512944.6_4) from GENCODE V47lift37
  Description: exocyst complex component 3 (from RefSeq NM_007277.5)
Gencode Transcript: ENST00000512944.6_4
Gencode Gene: ENSG00000180104.16_14
Transcript (Including UTRs)
   Position: hg19 chr5:443,291-467,405 Size: 24,115 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr5:446,321-467,013 Size: 20,693 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:443,291-467,405)mRNA (may differ from genome)Protein (745 aa)
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-  Comments and Description Text from UniProtKB
  ID: EXOC3_HUMAN
DESCRIPTION: RecName: Full=Exocyst complex component 3; AltName: Full=Exocyst complex component Sec6;
FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
SUBUNIT: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity).
SIMILARITY: Belongs to the SEC6 family.
SEQUENCE CAUTION: Sequence=BAB84912.1; Type=Frameshift; Positions=1, 563;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.65 RPKM in Pituitary
Total median expression: 769.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.70171-0.443 Picture PostScript Text
3' UTR -141.20392-0.360 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010326 - Sec6

Pfam Domains:
PF06046 - Exocyst complex component Sec6

ModBase Predicted Comparative 3D Structure on O60645
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000149 SNARE binding
GO:0005515 protein binding
GO:0045296 cadherin binding

Biological Process:
GO:0006887 exocytosis
GO:0015031 protein transport
GO:0051601 exocyst localization

Cellular Component:
GO:0000145 exocyst
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0030426 growth cone
GO:0030496 midbody
GO:0030667 secretory granule membrane
GO:0042995 cell projection
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK074086 - Homo sapiens mRNA for FLJ00157 protein.
GU727644 - Homo sapiens epididymis secretory sperm binding protein Li 19lP mRNA, complete cds.
JC506674 - Sequence 42 from Patent EP2733220.
JC737786 - Sequence 42 from Patent WO2014075939.
JC506688 - Sequence 56 from Patent EP2733220.
JC737800 - Sequence 56 from Patent WO2014075939.
JC506661 - Sequence 29 from Patent EP2733220.
JC737773 - Sequence 29 from Patent WO2014075939.
JC506666 - Sequence 34 from Patent EP2733220.
JC737778 - Sequence 34 from Patent WO2014075939.
JC506674 - Sequence 42 from Patent EP2733220.
JC737786 - Sequence 42 from Patent WO2014075939.
JC506688 - Sequence 56 from Patent EP2733220.
JC737800 - Sequence 56 from Patent WO2014075939.
BC064569 - Homo sapiens exocyst complex component 3, mRNA (cDNA clone MGC:74518 IMAGE:5590332), complete cds.
JD296870 - Sequence 277894 from Patent EP1572962.
KJ898404 - Synthetic construct Homo sapiens clone ccsbBroadEn_07798 EXOC3 gene, encodes complete protein.
AL832434 - Homo sapiens mRNA; cDNA DKFZp762K123 (from clone DKFZp762K123).
BC019304 - Homo sapiens exocyst complex component 3, mRNA (cDNA clone IMAGE:2823198), partial cds.
AK315749 - Homo sapiens cDNA, FLJ96859.
AK131103 - Homo sapiens mRNA for FLJ00339 protein.
BC001511 - Homo sapiens exocyst complex component 3, mRNA (cDNA clone IMAGE:2988233), partial cds.
BC010127 - Homo sapiens exocyst complex component 3, mRNA (cDNA clone IMAGE:3951643), **** WARNING: chimeric clone ****.
AF055006 - Homo sapiens clone 24666 sec6 homolog mRNA, partial cds.
JD208928 - Sequence 189952 from Patent EP1572962.
JD193897 - Sequence 174921 from Patent EP1572962.
JD101058 - Sequence 82082 from Patent EP1572962.
JD128354 - Sequence 109378 from Patent EP1572962.
JD233425 - Sequence 214449 from Patent EP1572962.
JD321884 - Sequence 302908 from Patent EP1572962.
JD398105 - Sequence 379129 from Patent EP1572962.
JD192423 - Sequence 173447 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O60645 (Reactome details) participates in the following event(s):

R-HSA-5623524 The exocyst complex binds to RAB3IP in the ciliary targeting complex
R-HSA-264876 Insulin processing
R-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-2980736 Peptide hormone metabolism
R-HSA-5620916 VxPx cargo-targeting to cilium
R-HSA-199991 Membrane Trafficking
R-HSA-392499 Metabolism of proteins
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5617833 Cilium Assembly
R-HSA-1852241 Organelle biogenesis and maintenance

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000512944.1, ENST00000512944.2, ENST00000512944.3, ENST00000512944.4, ENST00000512944.5, EXOC3_HUMAN, NM_007277, O60645, Q6P2E8, Q8TEN6, Q8WUW0, Q96DI4, SEC6, SEC6L1, uc323joi.1, uc323joi.2
UCSC ID: ENST00000512944.6_4
RefSeq Accession: NM_007277.5
Protein: O60645 (aka EXOC3_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.