ID:ERLN1_HUMAN DESCRIPTION: RecName: Full=Erlin-1; AltName: Full=Endoplasmic reticulum lipid raft-associated protein 1; AltName: Full=Protein KE04; AltName: Full=Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1; Short=SPFH domain-containing protein 1; FUNCTION: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). SUBUNIT: Forms a heteromeric complex with ERLIN2. In complex with ERLIN2, interacts with RNF170. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. TISSUE SPECIFICITY: Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine. SIMILARITY: Belongs to the band 7/mec-2 family. CAUTION: This sequence contains two in frame methionine codon situated in atypical consensus Kozak sequence in the 5'terminus. By homolog comparison, the second ATG was supposed to be the start codon according to PubMed:11118313. SEQUENCE CAUTION: Sequence=CAQ10515.1; Type=Erroneous initiation; Sequence=EAW49846.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75477
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0032933 SREBP signaling pathway GO:0045541 negative regulation of cholesterol biosynthetic process GO:0045717 negative regulation of fatty acid biosynthetic process GO:0055085 transmembrane transport
LF211340 - JP 2014500723-A/18843: Polycomb-Associated Non-Coding RNAs. BC031791 - Homo sapiens ER lipid raft associated 1, mRNA (cDNA clone MGC:24915 IMAGE:4214940), complete cds. AK127017 - Homo sapiens cDNA FLJ45073 fis, clone BRAWH3027420. JD519934 - Sequence 500958 from Patent EP1572962. LF345682 - JP 2014500723-A/153185: Polycomb-Associated Non-Coding RNAs. JD296654 - Sequence 277678 from Patent EP1572962. LF345683 - JP 2014500723-A/153186: Polycomb-Associated Non-Coding RNAs. JD546736 - Sequence 527760 from Patent EP1572962. JD355845 - Sequence 336869 from Patent EP1572962. LF345684 - JP 2014500723-A/153187: Polycomb-Associated Non-Coding RNAs. JD515046 - Sequence 496070 from Patent EP1572962. JD415901 - Sequence 396925 from Patent EP1572962. JD296117 - Sequence 277141 from Patent EP1572962. JD122499 - Sequence 103523 from Patent EP1572962. JD119559 - Sequence 100583 from Patent EP1572962. JD421057 - Sequence 402081 from Patent EP1572962. JD421300 - Sequence 402324 from Patent EP1572962. JD215184 - Sequence 196208 from Patent EP1572962. JD477309 - Sequence 458333 from Patent EP1572962. JD536028 - Sequence 517052 from Patent EP1572962. JD185170 - Sequence 166194 from Patent EP1572962. JD117982 - Sequence 99006 from Patent EP1572962. JD253077 - Sequence 234101 from Patent EP1572962. JD330208 - Sequence 311232 from Patent EP1572962. JD339691 - Sequence 320715 from Patent EP1572962. AK222480 - Homo sapiens mRNA for SPFH domain family, member 1 variant, clone: adKA01927. AF064093 - Homo sapiens KE04p mRNA, complete cds. JD117821 - Sequence 98845 from Patent EP1572962. LF345685 - JP 2014500723-A/153188: Polycomb-Associated Non-Coding RNAs. JD184049 - Sequence 165073 from Patent EP1572962. JD464043 - Sequence 445067 from Patent EP1572962. AK298427 - Homo sapiens cDNA FLJ57553 complete cds, highly similar to SPFH domain-containing protein 1 precursor. JD357107 - Sequence 338131 from Patent EP1572962. JD361137 - Sequence 342161 from Patent EP1572962. JD349866 - Sequence 330890 from Patent EP1572962. JD318637 - Sequence 299661 from Patent EP1572962. JD250751 - Sequence 231775 from Patent EP1572962. AK315580 - Homo sapiens cDNA, FLJ96656, highly similar to Homo sapiens SPFH domain family, member 1 (SPFH1), mRNA. KJ900813 - Synthetic construct Homo sapiens clone ccsbBroadEn_10207 ERLIN1 gene, encodes complete protein. DQ894532 - Synthetic construct Homo sapiens clone IMAGE:100008992; FLH171318.01L; RZPDo839H0699D SPFH domain family, member 1 (SPFH1) gene, encodes complete protein. EU176273 - Synthetic construct Homo sapiens clone IMAGE:100006380; FLH171325.01X; RZPDo839G11250D ER lipid raft associated 1 (ERLIN1) gene, encodes complete protein. AB528551 - Synthetic construct DNA, clone: pF1KB9925, Homo sapiens ERLIN1 gene for ER lipid raft associated 1, without stop codon, in Flexi system. CU689234 - Synthetic construct Homo sapiens gateway clone IMAGE:100019040 5' read ERLIN1 mRNA. LF345687 - JP 2014500723-A/153190: Polycomb-Associated Non-Coding RNAs. AK056574 - Homo sapiens cDNA FLJ32012 fis, clone NTONG1000006, highly similar to Homo sapiens KE04p mRNA. LF345689 - JP 2014500723-A/153192: Polycomb-Associated Non-Coding RNAs. LF345690 - JP 2014500723-A/153193: Polycomb-Associated Non-Coding RNAs. LF345696 - JP 2014500723-A/153199: Polycomb-Associated Non-Coding RNAs. LF345697 - JP 2014500723-A/153200: Polycomb-Associated Non-Coding RNAs. LF345698 - JP 2014500723-A/153201: Polycomb-Associated Non-Coding RNAs. MA581259 - JP 2018138019-A/153185: Polycomb-Associated Non-Coding RNAs. MA581260 - JP 2018138019-A/153186: Polycomb-Associated Non-Coding RNAs. MA581261 - JP 2018138019-A/153187: Polycomb-Associated Non-Coding RNAs. MA581262 - JP 2018138019-A/153188: Polycomb-Associated Non-Coding RNAs. MA581264 - JP 2018138019-A/153190: Polycomb-Associated Non-Coding RNAs. MA581266 - JP 2018138019-A/153192: Polycomb-Associated Non-Coding RNAs. MA581267 - JP 2018138019-A/153193: Polycomb-Associated Non-Coding RNAs. MA581273 - JP 2018138019-A/153199: Polycomb-Associated Non-Coding RNAs. MA581274 - JP 2018138019-A/153200: Polycomb-Associated Non-Coding RNAs. MA581275 - JP 2018138019-A/153201: Polycomb-Associated Non-Coding RNAs. MA446917 - JP 2018138019-A/18843: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75477 (Reactome details) participates in the following event(s):
R-HSA-8866551 CFTR binds components of the ERAD machinery for ubiquitination and degradation R-HSA-8866857 CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation R-HSA-8866542 VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol R-HSA-8866854 VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol R-HSA-8866546 RNF5 and RNF185 ubiquitinate misfolded CFTR R-HSA-8866856 RNF5 and RNF185 ubiquitinate CFTR F508del R-HSA-382556 ABC-family proteins mediated transport R-HSA-5678895 Defective CFTR causes cystic fibrosis R-HSA-382551 Transport of small molecules R-HSA-5619084 ABC transporter disorders R-HSA-5619115 Disorders of transmembrane transporters R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
