Human Gene ERI2 (ENST00000300005.7_6) from GENCODE V47lift37
  Description: ERI1 exoribonuclease family member 2, transcript variant 2 (from RefSeq NM_080663.3)
Gencode Transcript: ENST00000300005.7_6
Gencode Gene: ENSG00000196678.14_11
Transcript (Including UTRs)
   Position: hg19 chr16:20,791,515-20,817,795 Size: 26,281 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr16:20,791,964-20,817,752 Size: 25,789 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:20,791,515-20,817,795)mRNA (may differ from genome)Protein (328 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ERI2_HUMAN
DESCRIPTION: RecName: Full=ERI1 exoribonuclease 2; EC=3.1.-.-; AltName: Full=Exonuclease domain-containing protein 1;
COFACTOR: Binds 2 magnesium ions per subunit (By similarity).
SIMILARITY: Belongs to the ERI2 family.
SIMILARITY: Contains 1 exonuclease domain.
SEQUENCE CAUTION: Sequence=AAC31669.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.25 RPKM in Testis
Total median expression: 99.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.6043-0.316 Picture PostScript Text
3' UTR -99.90449-0.222 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006055 - Exonuclease
IPR013520 - Exonuclease_RNaseT/DNA_pol3
IPR012337 - RNaseH-like_dom
IPR010666 - Znf_GRF

Pfam Domains:
PF00929 - Exonuclease

SCOP Domains:
53098 - Ribonuclease H-like

ModBase Predicted Comparative 3D Structure on A8K979
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006259 DNA metabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis


-  Descriptions from all associated GenBank mRNAs
  BX648185 - Homo sapiens mRNA; cDNA DKFZp686G23203 (from clone DKFZp686G23203).
BC010503 - Homo sapiens exoribonuclease 2, mRNA (cDNA clone IMAGE:3450989), complete cds.
JD158454 - Sequence 139478 from Patent EP1572962.
JD300007 - Sequence 281031 from Patent EP1572962.
JD083779 - Sequence 64803 from Patent EP1572962.
JD552017 - Sequence 533041 from Patent EP1572962.
JD270006 - Sequence 251030 from Patent EP1572962.
JD539357 - Sequence 520381 from Patent EP1572962.
KJ899978 - Synthetic construct Homo sapiens clone ccsbBroadEn_09372 ERI2 gene, encodes complete protein.
DQ895001 - Synthetic construct Homo sapiens clone IMAGE:100009461; FLH263715.01L; RZPDo839H05131D exonuclease domain containing 1 (EXOD1) gene, encodes complete protein.
DQ895002 - Synthetic construct Homo sapiens clone IMAGE:100009462; FLH180208.01L; RZPDo839H06131D exonuclease domain containing 1 (EXOD1) gene, encodes complete protein.
AB590202 - Synthetic construct DNA, clone: pFN21AE1119, Homo sapiens ERI2 gene for ERI1 exoribonuclease family member 2, without stop codon, in Flexi system.
CU679731 - Synthetic construct Homo sapiens gateway clone IMAGE:100018959 5' read MGC16943 mRNA.
AB040937 - Homo sapiens mRNA for KIAA1504 protein, partial cds.
AK127391 - Homo sapiens cDNA FLJ45480 fis, clone BRTHA2001304.
AK304347 - Homo sapiens cDNA FLJ54777 complete cds, moderately similar to Mus musculus exonuclease domain containing 1 (Exod1), mRNA.
AK292594 - Homo sapiens cDNA FLJ77472 complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K979, ENST00000300005.1, ENST00000300005.2, ENST00000300005.3, ENST00000300005.4, ENST00000300005.5, ENST00000300005.6, ERI2_HUMAN, EXOD1, KIAA1504, NM_080663, Q6ZSJ2, Q96FR9, Q9P224, Q9Y6V3, uc317mms.1, uc317mms.2
UCSC ID: ENST00000300005.7_6
RefSeq Accession: NM_080663.3
Protein: A8K979 (aka ERI2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.