Human Gene EPHX1 (ENST00000272167.10_4) from GENCODE V47lift37
  Description: epoxide hydrolase 1, transcript variant 12 (from RefSeq NR_165625.1)
Gencode Transcript: ENST00000272167.10_4
Gencode Gene: ENSG00000143819.13_10
Transcript (Including UTRs)
   Position: hg19 chr1:225,997,826-226,033,264 Size: 35,439 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr1:226,016,431-226,033,048 Size: 16,618 Coding Exon Count: 8 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:225,997,826-226,033,264)mRNA (may differ from genome)Protein (455 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: EPHX1
Diseases sorted by gene-association score: hypercholanemia, familial* (779), preeclampsia/eclampsia 1* (391), ephx1-related familial hypercholanemia* (100), eclampsia (16), fetal hydantoin syndrome (13), pre-eclampsia (12), colorectal adenoma (7), valproate embryopathy, susceptibility to (7), pulmonary disease, chronic obstructive (6), geographic tongue (5), leber optic atrophy (5), stevens-johnson syndrome/toxic epidermal necrolysis (5), toxic encephalopathy (4), hypersensitivity syndrome, carbamazepine-induced (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 611.96 RPKM in Adrenal Gland
Total median expression: 3239.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.1051-0.257 Picture PostScript Text
3' UTR -43.90216-0.203 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  KJ891115 - Synthetic construct Homo sapiens clone ccsbBroadEn_00509 EPHX1 gene, encodes complete protein.
KR709870 - Synthetic construct Homo sapiens clone CCSBHm_00007052 EPHX1 (EPHX1) mRNA, encodes complete protein.
KR709871 - Synthetic construct Homo sapiens clone CCSBHm_00007054 EPHX1 (EPHX1) mRNA, encodes complete protein.
KR709872 - Synthetic construct Homo sapiens clone CCSBHm_00007055 EPHX1 (EPHX1) mRNA, encodes complete protein.
AK313436 - Homo sapiens cDNA, FLJ93975, highly similar to Homo sapiens epoxide hydrolase 1, microsomal (xenobiotic) (EPHX1), mRNA.
U34722 - Homo sapiens microsomal epoxide hydrolase (HYL1) mRNA, untranslated exon E1-b.
BC095430 - Homo sapiens epoxide hydrolase 1, microsomal (xenobiotic), mRNA (cDNA clone MGC:111065 IMAGE:30377793), complete cds.
BC003567 - Homo sapiens epoxide hydrolase 1, microsomal (xenobiotic), mRNA (cDNA clone MGC:2074 IMAGE:3547085), complete cds.
BC008291 - Homo sapiens epoxide hydrolase 1, microsomal (xenobiotic), mRNA (cDNA clone MGC:12851 IMAGE:3604417), complete cds.
KF032815 - Homo sapiens EPHX1 (EPHX1) mRNA, complete cds.
L25879 - Homo sapiens p53/HEH epoxide hydrolase (EPHX) mRNA, complete cds.
J03518 - Human epoxide hydrolase mRNA, complete cds.
Y00424 - Human mRNA for microsomal epoxide hydrolase (EC 3.3.2.3).
L25878 - Homo sapiens p33/HEH epoxide hydrolase (EPHX) mRNA, complete cds.
X07936 - Human mRNA for microsomal epoxide hydrolase (EC 3.3.2.3).
JD456219 - Sequence 437243 from Patent EP1572962.
DQ892506 - Synthetic construct clone IMAGE:100005136; FLH186985.01X; RZPDo839C0772D epoxide hydrolase 1, microsomal (xenobiotic) (EPHX1) gene, encodes complete protein.
DQ895720 - Synthetic construct Homo sapiens clone IMAGE:100010180; FLH186981.01L; RZPDo839C0762D epoxide hydrolase 1, microsomal (xenobiotic) (EPHX1) gene, encodes complete protein.
CU678903 - Synthetic construct Homo sapiens gateway clone IMAGE:100019484 5' read EPHX1 mRNA.
CR541963 - Homo sapiens full open reading frame cDNA clone RZPDo834E0734D for gene EPHX1, epoxide hydrolase 1, microsomal (xenobiotic); complete cds, without stopcodon.
KU178042 - Homo sapiens epoxide hydrolase 1 microsomal isoform 1 (EPHX1) mRNA, partial cds.
KU178043 - Homo sapiens epoxide hydrolase 1 microsomal isoform 2 (EPHX1) mRNA, complete cds, alternatively spliced.
M36374 - Human microsomal epoxide hydrolase (HmEH) mRNA, partial cds.
JD027404 - Sequence 8428 from Patent EP1572962.
JD436488 - Sequence 417512 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_eicosanoidPathway - Eicosanoid Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: A0A024R3P4, ENST00000272167.1, ENST00000272167.2, ENST00000272167.3, ENST00000272167.4, ENST00000272167.5, ENST00000272167.6, ENST00000272167.7, ENST00000272167.8, ENST00000272167.9, EPHX1 , hCG_2039431 , NR_165625, R4SBI6, R4SBI6_HUMAN, uc317ixr.1, uc317ixr.2
UCSC ID: ENST00000272167.10_4
RefSeq Accession: NM_001136018.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.