Human Gene ELF2 (ENST00000686138.1_4) from GENCODE V47lift37
  Description: E74 like ETS transcription factor 2, transcript variant 8 (from RefSeq NM_001371336.1)
Gencode Transcript: ENST00000686138.1_4
Gencode Gene: ENSG00000109381.21_14
Transcript (Including UTRs)
   Position: hg19 chr4:139,978,419-140,098,372 Size: 119,954 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr4:139,980,137-140,058,855 Size: 78,719 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:139,978,419-140,098,372)mRNA (may differ from genome)Protein (593 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ELF2_HUMAN
DESCRIPTION: RecName: Full=ETS-related transcription factor Elf-2; AltName: Full=E74-like factor 2; AltName: Full=New ETS-related factor;
FUNCTION: Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.
FUNCTION: Isoform 2 may function in repression of RUNX1-mediated transactivation.
SUBUNIT: Interacts with the LIM domains of LMO2 (By similarity). Interacts via its N-terminal region with RUNX1.
INTERACTION: Q01196:RUNX1; NbExp=2; IntAct=EBI-956941, EBI-925904;
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest levels of expression detected in heart, placenta, lung, skeletal muscle, spleen, thymus, testis and ovary. Moderate expression in prostate, small intestine, kidney, liver and pancreas, and weak expression in colon, brain and peripheral blood lymphocytes.
SIMILARITY: Belongs to the ETS family.
SIMILARITY: Contains 1 ETS DNA-binding domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ELF2
Diseases sorted by gene-association score: carpal tunnel syndrome, familial (2), nerve compression syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -187.90503-0.374 Picture PostScript Text
3' UTR -375.901718-0.219 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000418 - Ets
IPR022084 - TF_Elf_N
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00178 - Ets-domain
PF12310 - Transcription factor protein N terminal

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q15723
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0030154 cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050855 regulation of B cell receptor signaling pathway

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0016604 nuclear body


-  Descriptions from all associated GenBank mRNAs
  U43189 - Human Ets transcription factors NERF-1a and NERF-1b (NERF-1a,b) mRNA, complete cds.
U43188 - Human Ets transcription factor (NERF-2) mRNA, complete cds.
BC065025 - Homo sapiens E74-like factor 2 (ets domain transcription factor), mRNA (cDNA clone MGC:70862 IMAGE:6044351), complete cds.
AF256223 - Homo sapiens ets family transcription factor ELF2B (ELF2) mRNA, complete cds, alternatively spliced.
BC034951 - Homo sapiens E74-like factor 2 (ets domain transcription factor), mRNA (cDNA clone MGC:26206 IMAGE:4821608), complete cds.
AF256222 - Homo sapiens ets family transcription factor ELF2A (ELF2) mRNA, complete cds, alternatively spliced.
AK316455 - Homo sapiens cDNA, FLJ79354 complete cds, highly similar to ETS-related transcription factor Elf-2.
AK301307 - Homo sapiens cDNA FLJ53930 complete cds, highly similar to ETS-related transcription factor Elf-2.
DQ890870 - Synthetic construct clone IMAGE:100003500; FLH166662.01X; RZPDo839B1188D E74-like factor 2 (ets domain transcription factor) (ELF2) gene, encodes complete protein.
DQ894026 - Synthetic construct Homo sapiens clone IMAGE:100008486; FLH166658.01L; RZPDo839B1187D E74-like factor 2 (ets domain transcription factor) (ELF2) gene, encodes complete protein.
KJ896762 - Synthetic construct Homo sapiens clone ccsbBroadEn_06156 ELF2 gene, encodes complete protein.
KJ901405 - Synthetic construct Homo sapiens clone ccsbBroadEn_10799 ELF2 gene, encodes complete protein.
CU689992 - Synthetic construct Homo sapiens gateway clone IMAGE:100019804 5' read ELF2 mRNA.
CU688002 - Synthetic construct Homo sapiens gateway clone IMAGE:100021751 5' read ELF2 mRNA.
JD553967 - Sequence 534991 from Patent EP1572962.
JD061546 - Sequence 42570 from Patent EP1572962.
JD280002 - Sequence 261026 from Patent EP1572962.
JD280001 - Sequence 261025 from Patent EP1572962.
JD234643 - Sequence 215667 from Patent EP1572962.
JD081856 - Sequence 62880 from Patent EP1572962.
JD235218 - Sequence 216242 from Patent EP1572962.
JD562509 - Sequence 543533 from Patent EP1572962.
JD206838 - Sequence 187862 from Patent EP1572962.
JD098912 - Sequence 79936 from Patent EP1572962.
JD098911 - Sequence 79935 from Patent EP1572962.
AK303782 - Homo sapiens cDNA FLJ51444 complete cds, highly similar to ETS-related transcription factor Elf-2.
JD079258 - Sequence 60282 from Patent EP1572962.
JD378550 - Sequence 359574 from Patent EP1572962.
CQ873784 - Sequence 203 from Patent WO2004076622.
DD413621 - Regulation of Mammalian Cells.
JD250874 - Sequence 231898 from Patent EP1572962.
JD221760 - Sequence 202784 from Patent EP1572962.
JD449575 - Sequence 430599 from Patent EP1572962.
JD368916 - Sequence 349940 from Patent EP1572962.
DQ359746 - Homo sapiens ets family transcription factor ELF2C mRNA, complete cds, alternatively spliced.
LN626691 - Homo sapiens partial mRNA for E74-like factor 2 (ELF2 gene), sequence 1.
LN626692 - Homo sapiens partial mRNA for E74-like factor 2 (ELF2 gene), sequence 2.
AK311505 - Homo sapiens cDNA, FLJ18547.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q15723 (Reactome details) participates in the following event(s):

R-HSA-8938930 RUNX1 binds ELF2
R-HSA-8938965 RUNX1 and ELF1, ELF2 or PAX5 bind the BLK gene promoter
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: E9PCX3, ELF2 , ELF2_HUMAN, NERF , NM_001371336, Q15723, Q15724, Q15725, Q6P1K5, uc330pcu.1, uc330pcu.2
UCSC ID: ENST00000686138.1_4
RefSeq Accession: NM_001331036.3
Protein: Q15723 (aka ELF2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.