ID:IF6_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 6; Short=eIF-6; AltName: Full=B(2)GCN homolog; AltName: Full=B4 integrin interactor; AltName: Full=CAB; AltName: Full=p27(BBP); FUNCTION: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. SUBUNIT: Monomer. Associates with the 60S ribosomal subunit. Interacts with GNB2L1. INTERACTION: Q96C10:DHX58; NbExp=2; IntAct=EBI-372243, EBI-744193; P19525:EIF2AK2; NbExp=2; IntAct=EBI-372243, EBI-640775; Q9Y6K5:OAS3; NbExp=2; IntAct=EBI-372243, EBI-6115729; P68404:Prkcb (xeno); NbExp=2; IntAct=EBI-372243, EBI-397048; SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus. TISSUE SPECIFICITY: Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level). PTM: Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export. SIMILARITY: Belongs to the eIF-6 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P56537
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003743 translation initiation factor activity GO:0005515 protein binding GO:0043022 ribosome binding GO:0043023 ribosomal large subunit binding
Biological Process: GO:0000054 ribosomal subunit export from nucleus GO:0000460 maturation of 5.8S rRNA GO:0000470 maturation of LSU-rRNA GO:0006110 regulation of glycolytic process GO:0006412 translation GO:0006413 translational initiation GO:0032868 response to insulin GO:0035195 gene silencing by miRNA GO:0035278 miRNA mediated inhibition of translation GO:0042254 ribosome biogenesis GO:0042256 mature ribosome assembly GO:0042304 regulation of fatty acid biosynthetic process GO:0045652 regulation of megakaryocyte differentiation GO:0045727 positive regulation of translation GO:1902626 assembly of large subunit precursor of preribosome GO:2000377 regulation of reactive oxygen species metabolic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
