Human Gene EIF4G3 (ENST00000602326.6_8) from GENCODE V47lift37
  Description: eukaryotic translation initiation factor 4 gamma 3, transcript variant 19 (from RefSeq NM_001391906.1)
Gencode Transcript: ENST00000602326.6_8
Gencode Gene: ENSG00000075151.24_17
Transcript (Including UTRs)
   Position: hg19 chr1:21,132,972-21,503,390 Size: 370,419 Total Exon Count: 37 Strand: -
Coding Region
   Position: hg19 chr1:21,133,812-21,329,235 Size: 195,424 Coding Exon Count: 33 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:21,132,972-21,503,390)mRNA (may differ from genome)Protein (1641 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.17 RPKM in Testis
Total median expression: 592.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -243.60631-0.386 Picture PostScript Text
3' UTR -151.70840-0.181 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  AF012072 - Homo sapiens eIF4GII mRNA, complete cds.
AB209119 - Homo sapiens mRNA for eukaryotic translation initiation factor 4 gamma, 3 variant protein.
BC094683 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone MGC:102792 IMAGE:6188273), complete cds.
BC072413 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone IMAGE:6165611), partial cds.
BC136643 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone MGC:168256 IMAGE:9020633), complete cds.
BC144335 - Homo sapiens cDNA clone IMAGE:9052855, containing frame-shift errors.
AK294883 - Homo sapiens cDNA FLJ59298 complete cds, highly similar to Eukaryotic translation initiation factor 4 gamma 3.
AK225489 - Homo sapiens mRNA for Splice isoform 2 of O43432 variant, clone: JTH03575.
BC030578 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone IMAGE:4836870), complete cds.
AK302087 - Homo sapiens cDNA FLJ60945 complete cds, highly similar to Eukaryotic translation initiation factor 4gamma 3.
JD558073 - Sequence 539097 from Patent EP1572962.
AK302873 - Homo sapiens cDNA FLJ53944 complete cds, highly similar to Eukaryotic translation initiation factor 4 gamma 3.
JD261059 - Sequence 242083 from Patent EP1572962.
JD164334 - Sequence 145358 from Patent EP1572962.
Z34918 - H.sapiens mRNA for translation initiation factor eIF-4gamma (partial).
JD102602 - Sequence 83626 from Patent EP1572962.
AK310195 - Homo sapiens cDNA, FLJ17237.
BX647897 - Homo sapiens mRNA; cDNA DKFZp686C17112 (from clone DKFZp686C17112).
JD244587 - Sequence 225611 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_eifPathway - Eukaryotic protein translation
h_mTORPathway - mTOR Signaling Pathway
h_iresPathway - Internal Ribosome entry pathway

-  Other Names for This Gene
  Alternate Gene Symbols: A0A8J9G7U8, A0A8J9G7U8_HUMAN, EIF4G3 , ENST00000602326.1, ENST00000602326.2, ENST00000602326.3, ENST00000602326.4, ENST00000602326.5, NM_001391906, uc327glx.1, uc327glx.2
UCSC ID: ENST00000602326.6_8
RefSeq Accession: NM_001391906.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.