ID:EIF3K_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 3 subunit K; Short=eIF3k; AltName: Full=Eukaryotic translation initiation factor 3 subunit 12; AltName: Full=Muscle-specific gene M9 protein; AltName: Full=PLAC-24; AltName: Full=eIF-3 p25; AltName: Full=eIF-3 p28; FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. SUBUNIT: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2. INTERACTION: Q9Q2G4:ORF (xeno); NbExp=5; IntAct=EBI-354344, EBI-6248094; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. TISSUE SPECIFICITY: Ubiquitous, with the highest levels of expression in brain, testis and kidney. MASS SPECTROMETRY: Mass=24970.6; Method=Unknown; Range=1-218; Source=PubMed:17322308; MASS SPECTROMETRY: Mass=24971.1; Mass_error=0.2; Method=MALDI; Range=1-218; Source=PubMed:18599441; SIMILARITY: Belongs to the eIF-3 subunit K family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBQ5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
JX870647 - Homo sapiens eukaryotic translation initiation factor 3 subunit K isoform 2 (EIF3K) mRNA, complete cds, alternatively spliced. AF077051 - Homo sapiens PTD001 mRNA, complete cds. AF085358 - Homo sapiens HSPC029 mRNA, complete cds. AB019392 - Homo sapiens mRNA of muscle specific gene M9, complete cds. AY245432 - Homo sapiens eukaryotic translation initiation factor 3 subunit k mRNA, complete cds. BC007559 - Homo sapiens eukaryotic translation initiation factor 3, subunit K, mRNA (cDNA clone MGC:15486 IMAGE:2988566), complete cds. AK298635 - Homo sapiens cDNA FLJ55131 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 12. AK316344 - Homo sapiens cDNA, FLJ79243 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 12. AK301035 - Homo sapiens cDNA FLJ56725 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 12. AK289554 - Homo sapiens cDNA FLJ76597 complete cds, highly similar to Homo sapiens eukaryotic translation initiation factor 3, subunit 12 (EIF3S12), mRNA. AF109355 - Homo sapiens MSTP001 mRNA, complete cds. BC001031 - Homo sapiens eukaryotic translation initiation factor 3, subunit K, mRNA (cDNA clone MGC:1542 IMAGE:3139375), complete cds. AK026531 - Homo sapiens cDNA: FLJ22878 fis, clone KAT03361, highly similar to AF077051 Homo sapiens PTD001 mRNA. HQ447243 - Synthetic construct Homo sapiens clone IMAGE:100070548; CCSB005232_01 eukaryotic translation initiation factor 3, subunit 12 (EIF3K) gene, encodes complete protein. KJ893637 - Synthetic construct Homo sapiens clone ccsbBroadEn_03031 EIF3K gene, encodes complete protein. AF315506 - Homo sapiens ARG134 protein mRNA, complete cds. CU674510 - Synthetic construct Homo sapiens gateway clone IMAGE:100018040 5' read EIF3K mRNA. JD020827 - Sequence 1851 from Patent EP1572962. JD031793 - Sequence 12817 from Patent EP1572962. JD031948 - Sequence 12972 from Patent EP1572962. BC007335 - Homo sapiens eukaryotic translation initiation factor 3, subunit K, mRNA (cDNA clone IMAGE:3658687), partial cds. AF090927 - Homo sapiens clone HQ0457 PRO0457 mRNA, complete cds. JD021507 - Sequence 2531 from Patent EP1572962. JD021940 - Sequence 2964 from Patent EP1572962. JD030095 - Sequence 11119 from Patent EP1572962. JD383213 - Sequence 364237 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UBQ5 (Reactome details) participates in the following event(s):
R-HSA-72676 eIF3 and eIF1A bind to the 40S subunit R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-72691 Formation of the 43S pre-initiation complex R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72621 Ribosomal scanning R-HSA-72697 Start codon recognition R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72649 Translation initiation complex formation R-HSA-72737 Cap-dependent Translation Initiation R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-156827 L13a-mediated translation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72613 Eukaryotic Translation Initiation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
