ID:DNJA3_HUMAN DESCRIPTION: RecName: Full=DnaJ homolog subfamily A member 3, mitochondrial; AltName: Full=DnaJ protein Tid-1; Short=hTid-1; AltName: Full=Hepatocellular carcinoma-associated antigen 57; AltName: Full=Tumorous imaginal discs protein Tid56 homolog; Flags: Precursor; FUNCTION: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. SUBUNIT: Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain) (By similarity). INTERACTION: P08581:MET; NbExp=2; IntAct=EBI-3952284, EBI-1039152; P51692:STAT5B; NbExp=2; IntAct=EBI-356767, EBI-1186119; P42232:Stat5b (xeno); NbExp=2; IntAct=EBI-3952284, EBI-617454; SUBCELLULAR LOCATION: Mitochondrion matrix. Cytoplasm, cytosol (By similarity). Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein (By similarity). Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK (By similarity). TISSUE SPECIFICITY: Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. DOMAIN: Modulation of apoptosis, i.e proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain- dependent. PTM: Tyrosine phosphorylated (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 CR-type zinc finger. SIMILARITY: Contains 1 J domain. SEQUENCE CAUTION: Sequence=AAF66245.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAF66245.1; Type=Frameshift; Positions=408, 411; Sequence=AAH12343.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96EY1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006264 mitochondrial DNA replication GO:0006457 protein folding GO:0006469 negative regulation of protein kinase activity GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006924 activation-induced cell death of T cells GO:0007005 mitochondrion organization GO:0007264 small GTPase mediated signal transduction GO:0007528 neuromuscular junction development GO:0007569 cell aging GO:0008285 negative regulation of cell proliferation GO:0009408 response to heat GO:0031398 positive regulation of protein ubiquitination GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0033077 T cell differentiation in thymus GO:0034341 response to interferon-gamma GO:0042102 positive regulation of T cell proliferation GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043069 negative regulation of programmed cell death GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0050790 regulation of catalytic activity GO:0050821 protein stabilization GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway GO:0071340 skeletal muscle acetylcholine-gated channel clustering
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
