ID:DYXC1_HUMAN DESCRIPTION: RecName: Full=Dyslexia susceptibility 1 candidate gene 1 protein; FUNCTION: Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. SUBUNIT: Interacts with ESR1 and ESR2. Interacts with STUB1. INTERACTION: O95166:GABARAP; NbExp=4; IntAct=EBI-2946907, EBI-712001; Q9H0R8:GABARAPL1; NbExp=2; IntAct=EBI-2946907, EBI-746969; P60520:GABARAPL2; NbExp=2; IntAct=EBI-2946907, EBI-720116; Q9BXW4:MAP1LC3C; NbExp=2; IntAct=EBI-2946907, EBI-2603996; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. TISSUE SPECIFICITY: Expressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells. DISEASE: Defects in DYX1C1 may be a cause of susceptibility to dyslexia type 1 (DYX1) [MIM:127700]. A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. Note=A chromosomal aberration involving DYX1C1 has been found in a family affected by dyslexia. Translocation t(2;15)(q11;q21). SIMILARITY: Contains 1 CS domain. SIMILARITY: Contains 3 TPR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WXU2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0030331 estrogen receptor binding
Biological Process: GO:0001764 neuron migration GO:0003341 cilium movement GO:0007368 determination of left/right symmetry GO:0007399 nervous system development GO:0033146 regulation of intracellular estrogen receptor signaling pathway GO:0036158 outer dynein arm assembly GO:0036159 inner dynein arm assembly GO:0061136 regulation of proteasomal protein catabolic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
