ID:DLG1_HUMAN DESCRIPTION: RecName: Full=Disks large homolog 1; AltName: Full=Synapse-associated protein 97; Short=SAP-97; Short=SAP97; AltName: Full=hDlg; FUNCTION: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. SUBUNIT: Homotetramer (Probable). Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3, DLGAP4 and MAP1A. May interact with HTR2A (By similarity). Interacts with LRFN1 (By similarity). Interacts through its PDZ domains with GRIN2A, KCNA1, KCNA2, KCNA3, KCNA4, KCNA5, KCND2, KCND3, GRIA1, GPR124 and GPR125. Interacts with KCNF1. Interacts with CAMK2 (By similarity). Interacts with cytoskeleton-associated proteins EPB41 and EZR. Found in a complex with KCNA5 and CAV3. Found in a complex with APC and CTNNB1. Interacts with CDH1 through binding to PIK3R1. Forms multiprotein complexes with CASK, LIN7A, LIN7B, LIN7C, APBA1, and KCNJ12. Interacts through its guanylate kinase- like domain with KIF13B. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). May interact with TJAP1. Interacts with TOPK and the HTLV-1 viral Tax and HPV-18 E6 papillomavirus (HPV) oncoproteins. Interacts with PTEN (By similarity). Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2, LRFN4 and SFPQ. INTERACTION: Q9NQT8:KIF13B; NbExp=3; IntAct=EBI-357500, EBI-766408; O60333-3:KIF1B; NbExp=4; IntAct=EBI-357481, EBI-465669; SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein (By similarity). Basolateral cell membrane (By similarity). Endoplasmic reticulum membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse. Cell membrane, sarcolemma. Note=Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity). TISSUE SPECIFICITY: Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles. DOMAIN: The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 binding site mediating association to membranes in polarized and non-polarized cells. DOMAIN: The PDZ domains may also mediate association to membranes by binding to EPB41 and GPR124 together with the L27 domain that binds CASK and DLG2. DOMAIN: The L27 domain may regulate DLG1 self-association. The N- terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization. PTM: Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A. Isoform 2 is phosphorylated on Ser-698. Isoform 3 is phosphorylated on Ser-665 (By similarity). SIMILARITY: Belongs to the MAGUK family. SIMILARITY: Contains 1 guanylate kinase-like domain. SIMILARITY: Contains 1 L27 domain. SIMILARITY: Contains 3 PDZ (DHR) domains. SIMILARITY: Contains 1 SH3 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q12959
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001771 immunological synapse formation GO:0001935 endothelial cell proliferation GO:0002088 lens development in camera-type eye GO:0002369 T cell cytokine production GO:0006470 protein dephosphorylation GO:0007015 actin filament organization GO:0007093 mitotic cell cycle checkpoint GO:0007163 establishment or maintenance of cell polarity GO:0007268 chemical synaptic transmission GO:0007399 nervous system development GO:0008104 protein localization GO:0008284 positive regulation of cell proliferation GO:0008360 regulation of cell shape GO:0016032 viral process GO:0030432 peristalsis GO:0030838 positive regulation of actin filament polymerization GO:0030866 cortical actin cytoskeleton organization GO:0030953 astral microtubule organization GO:0031579 membrane raft organization GO:0031641 regulation of myelination GO:0032147 activation of protein kinase activity GO:0034220 ion transmembrane transport GO:0034629 cellular protein complex localization GO:0042110 T cell activation GO:0042130 negative regulation of T cell proliferation GO:0042391 regulation of membrane potential GO:0042982 amyloid precursor protein metabolic process GO:0043113 receptor clustering GO:0043268 positive regulation of potassium ion transport GO:0043622 cortical microtubule organization GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity GO:0045930 negative regulation of mitotic cell cycle GO:0046037 GMP metabolic process GO:0046710 GDP metabolic process GO:0048608 reproductive structure development GO:0048704 embryonic skeletal system morphogenesis GO:0048729 tissue morphogenesis GO:0048745 smooth muscle tissue development GO:0050680 negative regulation of epithelial cell proliferation GO:0051660 establishment of centrosome localization GO:0051898 negative regulation of protein kinase B signaling GO:0060022 hard palate development GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0070830 bicellular tight junction assembly GO:0072659 protein localization to plasma membrane GO:0097120 receptor localization to synapse GO:0098609 cell-cell adhesion GO:0098911 regulation of ventricular cardiac muscle cell action potential GO:1902305 regulation of sodium ion transmembrane transport GO:1903078 positive regulation of protein localization to plasma membrane GO:1903286 regulation of potassium ion import GO:1903753 negative regulation of p38MAPK cascade GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1903764 regulation of potassium ion export across plasma membrane GO:1901222 regulation of NIK/NF-kappaB signaling
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Common Gene Haplotype Alleles 
