Human Gene DHRS7B (ENST00000395511.8_10) from GENCODE V47lift37
  Description: dehydrogenase/reductase 7B, transcript variant 1 (from RefSeq NM_015510.5)
Gencode Transcript: ENST00000395511.8_10
Gencode Gene: ENSG00000109016.18_17
Transcript (Including UTRs)
   Position: hg19 chr17:21,030,277-21,094,733 Size: 64,457 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr17:21,030,285-21,094,466 Size: 64,182 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:21,030,277-21,094,733)mRNA (may differ from genome)Protein (325 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DRS7B_HUMAN
DESCRIPTION: RecName: Full=Dehydrogenase/reductase SDR family member 7B; EC=1.1.-.-;
FUNCTION: Putative oxidoreductase (Potential).
SUBCELLULAR LOCATION: Peroxisome membrane; Single-pass type II membrane protein (Potential).
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
SEQUENCE CAUTION: Sequence=AAD34088.1; Type=Frameshift; Positions=12, 266; Sequence=AAQ88862.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.05 RPKM in Testis
Total median expression: 290.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -65.80267-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002198 - DH_sc/Rdtase_SDR
IPR002347 - Glc/ribitol_DH
IPR016040 - NAD(P)-bd_dom
IPR020904 - Sc_DH/Rdtase_CS

Pfam Domains:
PF00106 - short chain dehydrogenase
PF08643 - Fungal family of unknown function (DUF1776)
PF08659 - KR domain
PF13561 - Enoyl-(Acyl carrier protein) reductase

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains

ModBase Predicted Comparative 3D Structure on Q6IAN0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0016491 oxidoreductase activity

Biological Process:
GO:0008150 biological_process
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ893502 - Synthetic construct Homo sapiens clone ccsbBroadEn_02896 DHRS7B gene, encodes complete protein.
AL117567 - Homo sapiens mRNA; cDNA DKFZp566O084 (from clone DKFZp566O084).
AF151851 - Homo sapiens CGI-93 protein mRNA, complete cds.
BC004126 - Homo sapiens dehydrogenase/reductase (SDR family) member 7B, mRNA (cDNA clone MGC:11222 IMAGE:3937286), complete cds.
BC009679 - Homo sapiens dehydrogenase/reductase (SDR family) member 7B, mRNA (cDNA clone MGC:8916 IMAGE:3878039), complete cds.
AK124055 - Homo sapiens cDNA FLJ42061 fis, clone SYNOV2005541.
CR457124 - Homo sapiens full open reading frame cDNA clone RZPDo834D0112D for gene DKFZp566O084, DKFZP566O084 protein; complete cds, incl. stopcodon.
AK309867 - Homo sapiens cDNA, FLJ99908.
AY358498 - Homo sapiens clone DNA35600 DFIT212 (UNQ212) mRNA, complete cds.
JD036447 - Sequence 17471 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B5MEF4, CGI-93, DHRS7B , DRS7B_HUMAN, ENST00000395511.1, ENST00000395511.2, ENST00000395511.3, ENST00000395511.4, ENST00000395511.5, ENST00000395511.6, ENST00000395511.7, NM_015510, Q6IAN0, Q6UX59, Q9BTF9, Q9UFM6, Q9Y3A1, SDR32C1 , uc318xlq.1, uc318xlq.2, UNQ212/PRO238
UCSC ID: ENST00000395511.8_10
RefSeq Accession: NM_015510.5
Protein: Q6IAN0 (aka DRS7B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.