Human Gene CPNE7 (ENST00000319518.13_7) from GENCODE V47lift37
  Description: copine 7, transcript variant 1 (from RefSeq NM_153636.3)
Gencode Transcript: ENST00000319518.13_7
Gencode Gene: ENSG00000178773.15_13
Transcript (Including UTRs)
   Position: hg19 chr16:89,642,166-89,663,654 Size: 21,489 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr16:89,642,306-89,663,029 Size: 20,724 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:89,642,166-89,663,654)mRNA (may differ from genome)Protein (558 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CPNE7_HUMAN
DESCRIPTION: RecName: Full=Copine-7; AltName: Full=Copine VII;
FUNCTION: May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity).
SIMILARITY: Belongs to the copine family.
SIMILARITY: Contains 2 C2 domains.
SIMILARITY: Contains 1 VWFA domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.39 RPKM in Pituitary
Total median expression: 116.11 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -72.50140-0.518 Picture PostScript Text
3' UTR -312.20625-0.500 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR018029 - C2_membr_targeting
IPR010734 - Copine
IPR002035 - VWF_A

Pfam Domains:
PF00168 - C2 domain
PF07002 - Copine

SCOP Domains:
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
53300 - vWA-like

ModBase Predicted Comparative 3D Structure on Q9UBL6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity
GO:0005515 protein binding

Biological Process:
GO:0006629 lipid metabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0071277 cellular response to calcium ion

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AJ133798 - Homo sapiens mRNA for copine VI protein.
BC064577 - Homo sapiens copine VII, mRNA (cDNA clone MGC:70404 IMAGE:5727324), complete cds.
BC035334 - Homo sapiens copine VII, mRNA (cDNA clone MGC:34192 IMAGE:5191900), complete cds.
JF432228 - Synthetic construct Homo sapiens clone IMAGE:100073393 copine VII (CPNE7) gene, encodes complete protein.
KJ898666 - Synthetic construct Homo sapiens clone ccsbBroadEn_08060 CPNE7 gene, encodes complete protein.
AB463543 - Synthetic construct DNA, clone: pF1KB8378, Homo sapiens CPNE7 gene for copine VII, without stop codon, in Flexi system.
CU690070 - Synthetic construct Homo sapiens gateway clone IMAGE:100019866 5' read CPNE7 mRNA.
JD232472 - Sequence 213496 from Patent EP1572962.
JD329753 - Sequence 310777 from Patent EP1572962.
JD183112 - Sequence 164136 from Patent EP1572962.
JD496721 - Sequence 477745 from Patent EP1572962.
JD540981 - Sequence 522005 from Patent EP1572962.
JD076819 - Sequence 57843 from Patent EP1572962.
JD393844 - Sequence 374868 from Patent EP1572962.
JD075668 - Sequence 56692 from Patent EP1572962.
JD190625 - Sequence 171649 from Patent EP1572962.
JD385034 - Sequence 366058 from Patent EP1572962.
JD216685 - Sequence 197709 from Patent EP1572962.
JD191009 - Sequence 172033 from Patent EP1572962.
JD442704 - Sequence 423728 from Patent EP1572962.
JD334883 - Sequence 315907 from Patent EP1572962.
JD455647 - Sequence 436671 from Patent EP1572962.
JD231524 - Sequence 212548 from Patent EP1572962.
JD391754 - Sequence 372778 from Patent EP1572962.
JD273862 - Sequence 254886 from Patent EP1572962.
JD485304 - Sequence 466328 from Patent EP1572962.
JD483814 - Sequence 464838 from Patent EP1572962.
JD227862 - Sequence 208886 from Patent EP1572962.
JD477182 - Sequence 458206 from Patent EP1572962.
JD409075 - Sequence 390099 from Patent EP1572962.
JD544542 - Sequence 525566 from Patent EP1572962.
JD537163 - Sequence 518187 from Patent EP1572962.
JD544219 - Sequence 525243 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UBL6 (Reactome details) participates in the following event(s):

R-HSA-5333678 CPNEs bind PL
R-HSA-1483206 Glycerophospholipid biosynthesis
R-HSA-1483257 Phospholipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: CPNE7 , CPNE7_HUMAN, ENST00000319518.1, ENST00000319518.10, ENST00000319518.11, ENST00000319518.12, ENST00000319518.2, ENST00000319518.3, ENST00000319518.4, ENST00000319518.5, ENST00000319518.6, ENST00000319518.7, ENST00000319518.8, ENST00000319518.9, NM_153636, Q9UBL6, uc317qro.1, uc317qro.2
UCSC ID: ENST00000319518.13_7
RefSeq Accession: NM_153636.3
Protein: Q9UBL6 (aka CPNE7_HUMAN or CNE7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.