Human Gene CPEB4 (ENST00000265085.10_7) from GENCODE V47lift37
  Description: cytoplasmic polyadenylation element binding protein 4, transcript variant 1 (from RefSeq NM_030627.4)
Gencode Transcript: ENST00000265085.10_7
Gencode Gene: ENSG00000113742.14_17
Transcript (Including UTRs)
   Position: hg19 chr5:173,315,352-173,388,983 Size: 73,632 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr5:173,316,737-173,383,140 Size: 66,404 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:173,315,352-173,388,983)mRNA (may differ from genome)Protein (729 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CPEB4_HUMAN
DESCRIPTION: RecName: Full=Cytoplasmic polyadenylation element-binding protein 4; Short=CPE-BP4; Short=CPE-binding protein 4; Short=hCPEB-4;
SIMILARITY: Belongs to the RRM CPEB family.
SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • D013749 Tetrachlorodibenzodioxin
  • D014635 Valproic Acid
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C023035 3,4,5,3',4'-pentachlorobiphenyl
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D015127 9,10-Dimethyl-1,2-benzanthracene
  • D000082 Acetaminophen
  • D016604 Aflatoxin B1
  • D001151 Arsenic
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.88 RPKM in Adrenal Gland
Total median expression: 333.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -411.901385-0.297 Picture PostScript Text
3' UTR -1370.375843-0.235 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF16366 - Cytoplasmic polyadenylation element-binding protein ZZ domain
PF16367 - RNA recognition motif

SCOP Domains:
54928 - RNA-binding domain, RBD

ModBase Predicted Comparative 3D Structure on Q17RY0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000900 translation repressor activity, nucleic acid binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0008135 translation factor activity, RNA binding
GO:0043022 ribosome binding
GO:0045182 translation regulator activity
GO:0046872 metal ion binding

Biological Process:
GO:0002931 response to ischemia
GO:0006412 translation
GO:0006417 regulation of translation
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0036294 cellular response to decreased oxygen levels
GO:0042149 cellular response to glucose starvation
GO:0043524 negative regulation of neuron apoptotic process
GO:0071230 cellular response to amino acid stimulus
GO:2000766 negative regulation of cytoplasmic translation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0048471 perinuclear region of cytoplasm
GO:1990124 messenger ribonucleoprotein complex


-  Descriptions from all associated GenBank mRNAs
  KJ903298 - Synthetic construct Homo sapiens clone ccsbBroadEn_12692 CPEB4 gene, encodes complete protein.
JD395559 - Sequence 376583 from Patent EP1572962.
JD473788 - Sequence 454812 from Patent EP1572962.
JD032616 - Sequence 13640 from Patent EP1572962.
JD407286 - Sequence 388310 from Patent EP1572962.
JD137633 - Sequence 118657 from Patent EP1572962.
JD068114 - Sequence 49138 from Patent EP1572962.
JD054770 - Sequence 35794 from Patent EP1572962.
JD205822 - Sequence 186846 from Patent EP1572962.
JD233759 - Sequence 214783 from Patent EP1572962.
JD037443 - Sequence 18467 from Patent EP1572962.
JD423054 - Sequence 404078 from Patent EP1572962.
JD327994 - Sequence 309018 from Patent EP1572962.
JD036742 - Sequence 17766 from Patent EP1572962.
BX538213 - Homo sapiens mRNA; cDNA DKFZp686F1544 (from clone DKFZp686F1544); complete cds.
BC117150 - Homo sapiens cytoplasmic polyadenylation element binding protein 4, mRNA (cDNA clone MGC:150759 IMAGE:40125701), complete cds.
BC143958 - Homo sapiens cytoplasmic polyadenylation element binding protein 4, mRNA (cDNA clone MGC:177493 IMAGE:9052476), complete cds.
BC143959 - Homo sapiens cytoplasmic polyadenylation element binding protein 4, mRNA (cDNA clone MGC:177494 IMAGE:9052477), complete cds.
JD362107 - Sequence 343131 from Patent EP1572962.
JD440538 - Sequence 421562 from Patent EP1572962.
AK310905 - Homo sapiens cDNA, FLJ17947.
AB051460 - Homo sapiens KIAA1673 mRNA for KIAA1673 protein.
AB385493 - Synthetic construct DNA, clone: pF1KA1673, Homo sapiens CPEB4 gene for cytoplasmic polyadenylation element-binding protein 4, complete cds, without stop codon, in Flexi system.
HQ258358 - Synthetic construct Homo sapiens clone IMAGE:100072667 cytoplasmic polyadenylation element binding protein 4 (CPEB4) gene, encodes complete protein.
BC036899 - Homo sapiens cytoplasmic polyadenylation element binding protein 4, mRNA (cDNA clone IMAGE:5496778), complete cds.
CU691446 - Synthetic construct Homo sapiens gateway clone IMAGE:100022703 5' read CPEB4 mRNA.
AB586689 - Homo sapiens CPEB 4 variant mRNA for cytoplasmic polyadenylation element binding protein 4 variant, complete cds.
JD165116 - Sequence 146140 from Patent EP1572962.
JD549713 - Sequence 530737 from Patent EP1572962.
JD391274 - Sequence 372298 from Patent EP1572962.
JD303324 - Sequence 284348 from Patent EP1572962.
JD465701 - Sequence 446725 from Patent EP1572962.
JD096231 - Sequence 77255 from Patent EP1572962.
JD299350 - Sequence 280374 from Patent EP1572962.
JD549494 - Sequence 530518 from Patent EP1572962.
JD186965 - Sequence 167989 from Patent EP1572962.
JD287633 - Sequence 268657 from Patent EP1572962.
JD360924 - Sequence 341948 from Patent EP1572962.
JD306720 - Sequence 287744 from Patent EP1572962.
JD083102 - Sequence 64126 from Patent EP1572962.
JD410798 - Sequence 391822 from Patent EP1572962.
JD551830 - Sequence 532854 from Patent EP1572962.
JD131086 - Sequence 112110 from Patent EP1572962.
JD303710 - Sequence 284734 from Patent EP1572962.
JD367899 - Sequence 348923 from Patent EP1572962.
JD285003 - Sequence 266027 from Patent EP1572962.
JD467534 - Sequence 448558 from Patent EP1572962.
JD303578 - Sequence 284602 from Patent EP1572962.
JD127356 - Sequence 108380 from Patent EP1572962.
JD510581 - Sequence 491605 from Patent EP1572962.
JD147412 - Sequence 128436 from Patent EP1572962.
JD302679 - Sequence 283703 from Patent EP1572962.
JD281743 - Sequence 262767 from Patent EP1572962.
JD550781 - Sequence 531805 from Patent EP1572962.
JD357382 - Sequence 338406 from Patent EP1572962.
JD504941 - Sequence 485965 from Patent EP1572962.
JD235726 - Sequence 216750 from Patent EP1572962.
JD102947 - Sequence 83971 from Patent EP1572962.
JD553336 - Sequence 534360 from Patent EP1572962.
JD245827 - Sequence 226851 from Patent EP1572962.
JD302113 - Sequence 283137 from Patent EP1572962.
JD501663 - Sequence 482687 from Patent EP1572962.
JD433733 - Sequence 414757 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B7ZLQ7, CPEB4_HUMAN, ENST00000265085.1, ENST00000265085.2, ENST00000265085.3, ENST00000265085.4, ENST00000265085.5, ENST00000265085.6, ENST00000265085.7, ENST00000265085.8, ENST00000265085.9, KIAA1673, NM_030627, Q17RY0, Q7Z310, Q8N405, Q9C0J0, uc317hyk.1, uc317hyk.2
UCSC ID: ENST00000265085.10_7
RefSeq Accession: NM_030627.4
Protein: Q17RY0 (aka CPEB4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.