Human Gene CORO1B (ENST00000341356.10_7) from GENCODE V47lift37
  Description: coronin 1B, transcript variant 1 (from RefSeq NM_020441.3)
Gencode Transcript: ENST00000341356.10_7
Gencode Gene: ENSG00000172725.14_11
Transcript (Including UTRs)
   Position: hg19 chr11:67,202,981-67,210,947 Size: 7,967 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr11:67,205,847-67,210,099 Size: 4,253 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:67,202,981-67,210,947)mRNA (may differ from genome)Protein (489 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: COR1B_HUMAN
DESCRIPTION: RecName: Full=Coronin-1B; AltName: Full=Coronin-2;
FUNCTION: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).
SUBUNIT: Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity).
INTERACTION: O15144:ARPC2; NbExp=2; IntAct=EBI-351152, EBI-352356; Q8WYL5:SSH1; NbExp=3; IntAct=EBI-351152, EBI-1222387;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers.
PTM: Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location.
SIMILARITY: Belongs to the WD repeat coronin family.
SIMILARITY: Contains 5 WD repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CORO1B
Diseases sorted by gene-association score: coronin-1a deficiency (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.81 RPKM in Spleen
Total median expression: 1150.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.1075-0.375 Picture PostScript Text
3' UTR -1349.902866-0.471 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015505 - Coronin
IPR015048 - DUF1899
IPR015049 - DUF1900
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat
PF08953 - Domain of unknown function (DUF1899)
PF16300 - Type of WD40 repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q9BR76
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0045296 cadherin binding
GO:0051015 actin filament binding
GO:0071933 Arp2/3 complex binding

Biological Process:
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
GO:0031529 ruffle organization
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation
GO:0035767 endothelial cell chemotaxis
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0042060 wound healing
GO:0051017 actin filament bundle assembly
GO:0071672 negative regulation of smooth muscle cell chemotaxis
GO:0090135 actin filament branching
GO:1902463 protein localization to cell leading edge
GO:2000394 positive regulation of lamellipodium morphogenesis

Cellular Component:
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0030027 lamellipodium
GO:0031252 cell leading edge
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0071944 cell periphery


-  Descriptions from all associated GenBank mRNAs
  X81422 - H.sapiens mRNA for LPAP protein.
AB209579 - Homo sapiens mRNA for coronin, actin binding protein, 1B variant protein.
LF211139 - JP 2014500723-A/18642: Polycomb-Associated Non-Coding RNAs.
BC113859 - Homo sapiens protein tyrosine phosphatase, receptor type, C-associated protein, mRNA (cDNA clone MGC:138603 IMAGE:40030438), complete cds.
BC114467 - Homo sapiens protein tyrosine phosphatase, receptor type, C-associated protein, mRNA (cDNA clone MGC:138602 IMAGE:40030437), complete cds.
JD459863 - Sequence 440887 from Patent EP1572962.
JD335133 - Sequence 316157 from Patent EP1572962.
JD366876 - Sequence 347900 from Patent EP1572962.
AK312022 - Homo sapiens cDNA, FLJ92298, Homo sapiens protein tyrosine phosphatase, receptor type,C-associated protein (PTPRCAP), mRNA.
KJ891950 - Synthetic construct Homo sapiens clone ccsbBroadEn_01344 PTPRCAP gene, encodes complete protein.
AB527931 - Synthetic construct DNA, clone: pF1KB0967, Homo sapiens PTPRCAP gene for protein tyrosine phosphatase, receptor type, C-associated protein, without stop codon, in Flexi system.
CR457429 - Homo sapiens full open reading frame cDNA clone RZPDo834E0816D for gene PTPRCAP, protein tyrosine phosphatase, receptor type, C-associated protein; complete cds, incl. stopcodon.
BC006449 - Homo sapiens coronin, actin binding protein, 1B, mRNA (cDNA clone MGC:13215 IMAGE:3958930), complete cds.
AL162072 - Homo sapiens mRNA; cDNA DKFZp762I166 (from clone DKFZp762I166); partial cds.
AK000860 - Homo sapiens cDNA FLJ20853 fis, clone ADKA01365, highly similar to CORO_BOVIN CORONIN-LIKE PROTEIN P57.
JD446172 - Sequence 427196 from Patent EP1572962.
JD472138 - Sequence 453162 from Patent EP1572962.
JD127015 - Sequence 108039 from Patent EP1572962.
JD519390 - Sequence 500414 from Patent EP1572962.
LF344239 - JP 2014500723-A/151742: Polycomb-Associated Non-Coding RNAs.
LF344238 - JP 2014500723-A/151741: Polycomb-Associated Non-Coding RNAs.
JD200202 - Sequence 181226 from Patent EP1572962.
JD219687 - Sequence 200711 from Patent EP1572962.
JD156937 - Sequence 137961 from Patent EP1572962.
JD389625 - Sequence 370649 from Patent EP1572962.
JD405766 - Sequence 386790 from Patent EP1572962.
DQ893397 - Synthetic construct clone IMAGE:100006027; FLH199473.01X; RZPDo839C0582D coronin, actin binding protein, 1B (CORO1B) gene, encodes complete protein.
DQ896718 - Synthetic construct Homo sapiens clone IMAGE:100011178; FLH199379.01L; RZPDo839C0581D coronin, actin binding protein, 1B (CORO1B) gene, encodes complete protein.
AK315399 - Homo sapiens cDNA, FLJ96447, Homo sapiens coronin, actin binding protein, 1B (CORO1B), mRNA.
KJ894406 - Synthetic construct Homo sapiens clone ccsbBroadEn_03800 CORO1B gene, encodes complete protein.
AB528348 - Synthetic construct DNA, clone: pF1KB9933, Homo sapiens CORO1B gene for coronin, actin binding protein, 1B, without stop codon, in Flexi system.
LF344237 - JP 2014500723-A/151740: Polycomb-Associated Non-Coding RNAs.
AK295782 - Homo sapiens cDNA FLJ60046 complete cds, highly similar to Coronin-1B.
AK309267 - Homo sapiens cDNA, FLJ99308.
CU675409 - Synthetic construct Homo sapiens gateway clone IMAGE:100019637 5' read CORO1B mRNA.
JD026790 - Sequence 7814 from Patent EP1572962.
MA579816 - JP 2018138019-A/151742: Polycomb-Associated Non-Coding RNAs.
MA579815 - JP 2018138019-A/151741: Polycomb-Associated Non-Coding RNAs.
MA579814 - JP 2018138019-A/151740: Polycomb-Associated Non-Coding RNAs.
MA446716 - JP 2018138019-A/18642: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RD45, COR1B_HUMAN, ENST00000341356.1, ENST00000341356.2, ENST00000341356.3, ENST00000341356.4, ENST00000341356.5, ENST00000341356.6, ENST00000341356.7, ENST00000341356.8, ENST00000341356.9, NM_020441, Q9BR76, uc317vzn.1, uc317vzn.2
UCSC ID: ENST00000341356.10_7
RefSeq Accession: NM_020441.3
Protein: Q9BR76 (aka COR1B_HUMAN or CO1B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.