ID:COG2_HUMAN DESCRIPTION: RecName: Full=Conserved oligomeric Golgi complex subunit 2; Short=COG complex subunit 2; AltName: Full=Component of oligomeric Golgi complex 2; AltName: Full=Low density lipoprotein receptor defect C-complementing protein; FUNCTION: Required for normal Golgi morphology and function. SUBUNIT: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. INTERACTION: Q9H9E3:COG4; NbExp=2; IntAct=EBI-389449, EBI-368382; SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (Probable). SIMILARITY: Belongs to the COG2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14746
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008565 protein transporter activity GO:0044877 macromolecular complex binding
Biological Process: GO:0006888 ER to Golgi vesicle-mediated transport GO:0006891 intra-Golgi vesicle-mediated transport GO:0007030 Golgi organization GO:0015031 protein transport
AL832190 - Homo sapiens mRNA; cDNA DKFZp686A202 (from clone DKFZp686A202). BC014960 - Homo sapiens component of oligomeric golgi complex 2, mRNA (cDNA clone MGC:23019 IMAGE:4876271), complete cds. AK302791 - Homo sapiens cDNA FLJ50926 complete cds, highly similar to Conserved oligomeric Golgi complex component 2. Z34975 - Homo sapiens mRNA for Cog2. AK312678 - Homo sapiens cDNA, FLJ93071, Homo sapiens component of oligomeric golgi complex 2 (COG2), mRNA. BC051906 - Homo sapiens component of oligomeric golgi complex 2, mRNA (cDNA clone MGC:60373 IMAGE:4541036), complete cds. DQ895445 - Synthetic construct Homo sapiens clone IMAGE:100009905; FLH184457.01L; RZPDo839G03143D component of oligomeric golgi complex 2 (COG2) gene, encodes complete protein. KJ893289 - Synthetic construct Homo sapiens clone ccsbBroadEn_02683 COG2 gene, encodes complete protein. DQ892244 - Synthetic construct clone IMAGE:100004874; FLH184461.01X; RZPDo839G03144D component of oligomeric golgi complex 2 (COG2) gene, encodes complete protein. EU176335 - Synthetic construct Homo sapiens clone IMAGE:100006550; FLH263525.01X; RZPDo839B08251D component of oligomeric golgi complex 2 (COG2) gene, encodes complete protein. AK295251 - Homo sapiens cDNA FLJ55945 complete cds, highly similar to Conserved oligomeric Golgi complex component 2. AK302288 - Homo sapiens cDNA FLJ53111 complete cds, highly similar to Conserved oligomeric Golgi complex component 2. JD497362 - Sequence 478386 from Patent EP1572962. CU677137 - Synthetic construct Homo sapiens gateway clone IMAGE:100020432 5' read COG2 mRNA. S77362 - transcript ch4822 [human, RF1,RF48 stomach cancer cell lines, mRNA, 300 nt]. JD163392 - Sequence 144416 from Patent EP1572962. JD328594 - Sequence 309618 from Patent EP1572962. JD360077 - Sequence 341101 from Patent EP1572962. JD327560 - Sequence 308584 from Patent EP1572962. JD233381 - Sequence 214405 from Patent EP1572962. JD549004 - Sequence 530028 from Patent EP1572962. JD266297 - Sequence 247321 from Patent EP1572962. JD400215 - Sequence 381239 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q14746 (Reactome details) participates in the following event(s):
R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane R-HSA-8847544 The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering R-HSA-8849748 The COG complex binds RABs at the Golgi membrane R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811438 Intra-Golgi traffic R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
