Human Gene CLTC (ENST00000269122.8_11) from GENCODE V47lift37
  Description: clathrin heavy chain, transcript variant 1 (from RefSeq NM_004859.4)
Gencode Transcript: ENST00000269122.8_11
Gencode Gene: ENSG00000141367.14_15
Transcript (Including UTRs)
   Position: hg19 chr17:57,697,256-57,774,317 Size: 77,062 Total Exon Count: 32 Strand: +
Coding Region
   Position: hg19 chr17:57,697,493-57,771,213 Size: 73,721 Coding Exon Count: 32 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:57,697,256-57,774,317)mRNA (may differ from genome)Protein (1675 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CLH1_HUMAN
DESCRIPTION: RecName: Full=Clathrin heavy chain 1; AltName: Full=Clathrin heavy chain on chromosome 17; Short=CLH-17;
FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
SUBUNIT: Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1. Interacts with DENND1A, DENND1B and DENND1C (By similarity). May interact with OCRL. Interacts with ERBB2 (By similarity).
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SIMILARITY: Belongs to the clathrin heavy chain family.
SEQUENCE CAUTION: Sequence=BAA04801.2; Type=Erroneous initiation;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CLTCID360.html";
WEB RESOURCE: Name=Wikipedia; Note=Clathrin entry; URL="http://en.wikipedia.org/wiki/Clathrin";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CLTC
Diseases sorted by gene-association score: inflammatory myofibroblastic tumor* (160), renal cell carcinoma, papillary* (124), mesenchymal cell neoplasm (6), pediatric fibrosarcoma (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 61.63 RPKM in Cells - Cultured fibroblasts
Total median expression: 1793.59 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -79.20237-0.334 Picture PostScript Text
3' UTR -803.903104-0.259 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR000547 - Clathrin_H-chain/VPS_repeat
IPR016025 - Clathrin_H-chain_link/propller
IPR015348 - Clathrin_H-chain_linker_core
IPR001473 - Clathrin_H-chain_propeller_N
IPR022365 - Clathrin_H-chain_propeller_rpt
IPR016341 - Clathrin_heavy_chain
IPR011990 - TPR-like_helical

Pfam Domains:
PF00637 - Region in Clathrin and VPS
PF01394 - Clathrin propeller repeat
PF09268 - Clathrin, heavy-chain linker
PF13838 - Clathrin-H-link

SCOP Domains:
48371 - ARM repeat
48452 - TPR-like
47240 - Ferritin-like
63829 - Calcium-dependent phosphotriesterase
101898 - NHL repeat
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50978 - WD40 repeat-like
50989 - Clathrin heavy-chain terminal domain
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like
51658 - Xylose isomerase-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2XZG - X-ray MuPIT 4G55 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q00610
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0032051 clathrin light chain binding
GO:0050750 low-density lipoprotein particle receptor binding
GO:0097718 disordered domain specific binding
GO:1990381 ubiquitin-specific protease binding

Biological Process:
GO:0000278 mitotic cell cycle
GO:0001649 osteoblast differentiation
GO:0006886 intracellular protein transport
GO:0006898 receptor-mediated endocytosis
GO:0006914 autophagy
GO:0007049 cell cycle
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031623 receptor internalization
GO:0032802 low-density lipoprotein particle receptor catabolic process
GO:0033572 transferrin transport
GO:0034383 low-density lipoprotein particle clearance
GO:0042147 retrograde transport, endosome to Golgi
GO:0045056 transcytosis
GO:0048268 clathrin coat assembly
GO:0051301 cell division
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060236 regulation of mitotic spindle organization
GO:0061024 membrane organization
GO:0072583 clathrin-dependent endocytosis
GO:1900126 negative regulation of hyaluronan biosynthetic process
GO:1903077 negative regulation of protein localization to plasma membrane

Cellular Component:
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030118 clathrin coat
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit
GO:0030136 clathrin-coated vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0032588 trans-Golgi network membrane
GO:0032991 macromolecular complex
GO:0036020 endolysosome membrane
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0045334 clathrin-coated endocytic vesicle
GO:0070062 extracellular exosome
GO:0071439 clathrin complex
GO:0072686 mitotic spindle
GO:1903561 extracellular vesicle
GO:1990498 mitotic spindle microtubule


-  Descriptions from all associated GenBank mRNAs
  LF209247 - JP 2014500723-A/16750: Polycomb-Associated Non-Coding RNAs.
BC054489 - Homo sapiens clathrin, heavy chain (Hc), mRNA (cDNA clone MGC:51918 IMAGE:6045540), complete cds.
BX640615 - Homo sapiens mRNA; cDNA DKFZp686F12112 (from clone DKFZp686F12112).
BC051800 - Homo sapiens clathrin, heavy chain (Hc), mRNA (cDNA clone MGC:57689 IMAGE:6187185), complete cds.
AK127134 - Homo sapiens cDNA FLJ45191 fis, clone BRAWH3049365, highly similar to Clathrin heavy chain.
JD128751 - Sequence 109775 from Patent EP1572962.
D21260 - Homo sapiens KIAA0034 mRNA.
LF327214 - JP 2014500723-A/134717: Polycomb-Associated Non-Coding RNAs.
JD540351 - Sequence 521375 from Patent EP1572962.
LF327213 - JP 2014500723-A/134716: Polycomb-Associated Non-Coding RNAs.
AB587306 - Synthetic construct DNA, clone: pF1KA0034, Homo sapiens CLTC gene for clathrin, heavy chain, without stop codon, in Flexi system.
LF327206 - JP 2014500723-A/134709: Polycomb-Associated Non-Coding RNAs.
HZ473972 - WO 2016002844-A/86: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL.
LF327205 - JP 2014500723-A/134708: Polycomb-Associated Non-Coding RNAs.
HZ473971 - WO 2016002844-A/85: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL.
LF327203 - JP 2014500723-A/134706: Polycomb-Associated Non-Coding RNAs.
LF327202 - JP 2014500723-A/134705: Polycomb-Associated Non-Coding RNAs.
LF327201 - JP 2014500723-A/134704: Polycomb-Associated Non-Coding RNAs.
LF327200 - JP 2014500723-A/134703: Polycomb-Associated Non-Coding RNAs.
HZ473973 - WO 2016002844-A/87: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL.
LF327199 - JP 2014500723-A/134702: Polycomb-Associated Non-Coding RNAs.
LF327198 - JP 2014500723-A/134701: Polycomb-Associated Non-Coding RNAs.
LF327197 - JP 2014500723-A/134700: Polycomb-Associated Non-Coding RNAs.
X55878 - Human mRNA for clathrin heavy chain, partial.
LF327196 - JP 2014500723-A/134699: Polycomb-Associated Non-Coding RNAs.
JD020801 - Sequence 1825 from Patent EP1572962.
JD032962 - Sequence 13986 from Patent EP1572962.
HZ473974 - WO 2016002844-A/88: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL.
LF327195 - JP 2014500723-A/134698: Polycomb-Associated Non-Coding RNAs.
JD028227 - Sequence 9251 from Patent EP1572962.
LF327194 - JP 2014500723-A/134697: Polycomb-Associated Non-Coding RNAs.
LF327191 - JP 2014500723-A/134694: Polycomb-Associated Non-Coding RNAs.
LF327190 - JP 2014500723-A/134693: Polycomb-Associated Non-Coding RNAs.
LF327189 - JP 2014500723-A/134692: Polycomb-Associated Non-Coding RNAs.
LF327188 - JP 2014500723-A/134691: Polycomb-Associated Non-Coding RNAs.
LF327187 - JP 2014500723-A/134690: Polycomb-Associated Non-Coding RNAs.
LF327186 - JP 2014500723-A/134689: Polycomb-Associated Non-Coding RNAs.
LF327185 - JP 2014500723-A/134688: Polycomb-Associated Non-Coding RNAs.
LF327184 - JP 2014500723-A/134687: Polycomb-Associated Non-Coding RNAs.
LF327183 - JP 2014500723-A/134686: Polycomb-Associated Non-Coding RNAs.
LF327182 - JP 2014500723-A/134685: Polycomb-Associated Non-Coding RNAs.
AB073891 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla03086, full insert sequence.
LF327181 - JP 2014500723-A/134684: Polycomb-Associated Non-Coding RNAs.
LF327180 - JP 2014500723-A/134683: Polycomb-Associated Non-Coding RNAs.
JD026051 - Sequence 7075 from Patent EP1572962.
JD030130 - Sequence 11154 from Patent EP1572962.
JD034057 - Sequence 15081 from Patent EP1572962.
LF327179 - JP 2014500723-A/134682: Polycomb-Associated Non-Coding RNAs.
BC015854 - Homo sapiens clathrin, heavy chain (Hc), mRNA (cDNA clone IMAGE:4663039), with apparent retained intron.
LF327178 - JP 2014500723-A/134681: Polycomb-Associated Non-Coding RNAs.
AF130062 - Homo sapiens clone FLB7715 PRO2051 mRNA, complete cds.
LF327177 - JP 2014500723-A/134680: Polycomb-Associated Non-Coding RNAs.
LF327176 - JP 2014500723-A/134679: Polycomb-Associated Non-Coding RNAs.
BC036430 - Homo sapiens clathrin, heavy chain (Hc), mRNA (cDNA clone IMAGE:4812912), complete cds.
JD071107 - Sequence 52131 from Patent EP1572962.
JD563194 - Sequence 544218 from Patent EP1572962.
JD164590 - Sequence 145614 from Patent EP1572962.
JD233625 - Sequence 214649 from Patent EP1572962.
JD288430 - Sequence 269454 from Patent EP1572962.
JD034697 - Sequence 15721 from Patent EP1572962.
LF327174 - JP 2014500723-A/134677: Polycomb-Associated Non-Coding RNAs.
JD439332 - Sequence 420356 from Patent EP1572962.
JD251708 - Sequence 232732 from Patent EP1572962.
LF327173 - JP 2014500723-A/134676: Polycomb-Associated Non-Coding RNAs.
LF327172 - JP 2014500723-A/134675: Polycomb-Associated Non-Coding RNAs.
MA562791 - JP 2018138019-A/134717: Polycomb-Associated Non-Coding RNAs.
MA562790 - JP 2018138019-A/134716: Polycomb-Associated Non-Coding RNAs.
MA562783 - JP 2018138019-A/134709: Polycomb-Associated Non-Coding RNAs.
MA562782 - JP 2018138019-A/134708: Polycomb-Associated Non-Coding RNAs.
MA562780 - JP 2018138019-A/134706: Polycomb-Associated Non-Coding RNAs.
MA562779 - JP 2018138019-A/134705: Polycomb-Associated Non-Coding RNAs.
MA562778 - JP 2018138019-A/134704: Polycomb-Associated Non-Coding RNAs.
MA562777 - JP 2018138019-A/134703: Polycomb-Associated Non-Coding RNAs.
MA562776 - JP 2018138019-A/134702: Polycomb-Associated Non-Coding RNAs.
MA562775 - JP 2018138019-A/134701: Polycomb-Associated Non-Coding RNAs.
MA562774 - JP 2018138019-A/134700: Polycomb-Associated Non-Coding RNAs.
MA562773 - JP 2018138019-A/134699: Polycomb-Associated Non-Coding RNAs.
MA562772 - JP 2018138019-A/134698: Polycomb-Associated Non-Coding RNAs.
MA562771 - JP 2018138019-A/134697: Polycomb-Associated Non-Coding RNAs.
MA562768 - JP 2018138019-A/134694: Polycomb-Associated Non-Coding RNAs.
MA562767 - JP 2018138019-A/134693: Polycomb-Associated Non-Coding RNAs.
MA562766 - JP 2018138019-A/134692: Polycomb-Associated Non-Coding RNAs.
MA562765 - JP 2018138019-A/134691: Polycomb-Associated Non-Coding RNAs.
MA562764 - JP 2018138019-A/134690: Polycomb-Associated Non-Coding RNAs.
MA562763 - JP 2018138019-A/134689: Polycomb-Associated Non-Coding RNAs.
MA562762 - JP 2018138019-A/134688: Polycomb-Associated Non-Coding RNAs.
MA562761 - JP 2018138019-A/134687: Polycomb-Associated Non-Coding RNAs.
MA562760 - JP 2018138019-A/134686: Polycomb-Associated Non-Coding RNAs.
MA562759 - JP 2018138019-A/134685: Polycomb-Associated Non-Coding RNAs.
MA562758 - JP 2018138019-A/134684: Polycomb-Associated Non-Coding RNAs.
MA562757 - JP 2018138019-A/134683: Polycomb-Associated Non-Coding RNAs.
MA562756 - JP 2018138019-A/134682: Polycomb-Associated Non-Coding RNAs.
MA562755 - JP 2018138019-A/134681: Polycomb-Associated Non-Coding RNAs.
MA562754 - JP 2018138019-A/134680: Polycomb-Associated Non-Coding RNAs.
MA562753 - JP 2018138019-A/134679: Polycomb-Associated Non-Coding RNAs.
MA562751 - JP 2018138019-A/134677: Polycomb-Associated Non-Coding RNAs.
MA562750 - JP 2018138019-A/134676: Polycomb-Associated Non-Coding RNAs.
MA562749 - JP 2018138019-A/134675: Polycomb-Associated Non-Coding RNAs.
MA444824 - JP 2018138019-A/16750: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q00610 (Reactome details) participates in the following event(s):

R-HSA-421831 trans-Golgi Network Coat Assembly
R-HSA-432706 trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly
R-HSA-421836 trans-Golgi Network Derived Vesicle Uncoating
R-HSA-432688 trans-Golgi Network Derived Lysosomal Vesicle Uncoating
R-HSA-2213236 TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome
R-HSA-421835 trans-Golgi Network Vesicle Scission
R-HSA-432707 trans-Golgi Network Lysosomal Vesicle Scission
R-HSA-8951498 Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex
R-HSA-2130641 Translocation of TGN-lysosome vesicle to lysosome
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-2132295 MHC class II antigen presentation
R-HSA-421837 Clathrin derived vesicle budding
R-HSA-1280218 Adaptive Immune System
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-168256 Immune System
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport
R-HSA-177491 Formation of clathrin-coated vesicle
R-HSA-392748 L1 binds to AP-2 Clathrin complex
R-HSA-2130640 Recruitment of clathrin coated vesicle by Ii
R-HSA-6784735 PCSK9:LDLR bind to Clathrin
R-HSA-8855131 VLDLR:PCSK9 binds Clathrin-coated vesicles
R-HSA-445071 Reinsertion of L1 into the plasma membrane
R-HSA-5138433 p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis
R-HSA-5333658 CLAT:AP1:CLVS bind PI(3,5)P2
R-HSA-8856808 Recruitment of AP-2 complex and clathrin
R-HSA-8871196 Initial binding of AP-2 and clathrin to PI(4,5)P2
R-HSA-2130486 Uncoating of clathrin-coated vesicles and fusion with endosomes
R-HSA-177479 Axonal transport of NGF:Trk complexes
R-HSA-177501 Endocytosis (internalization) of clathrin-coated vesicle
R-HSA-374696 Phosphorylation of L1 by p90rsk
R-HSA-392749 Transport of L1 into endosomes
R-HSA-555065 Formation of clathrin coated vesicle
R-HSA-445077 Transport of L1 from C-domain to P-domain
R-HSA-445079 Phosphorylation of L1 by ERK
R-HSA-6784729 PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome
R-HSA-196026 Dab2 is recruited to the junctional plaques
R-HSA-8866283 ARBB recruits GPCRs into clathrin-coated pits
R-HSA-8867756 CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
R-HSA-8856813 AAK1 phosphorylates AP-2 mu subunit at T156
R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
R-HSA-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle
R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission
R-HSA-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P
R-HSA-8862280 FCHo proteins bind nascent clathrin-coated pit
R-HSA-8866279 Epsin family proteins bind ubiquitinated cargo
R-HSA-196017 Dynamin is recruited to the gap junction plaque
R-HSA-8868071 Clathrin recruits PIK3C2A
R-HSA-8868230 SNX9 recruits components of the actin polymerizing machinery
R-HSA-8867754 F- and N- BAR domain proteins bind the clathrin-coated pit
R-HSA-190519 Internalization of gap junction plaques
R-HSA-8868236 BAR domain proteins recruit dynamin
R-HSA-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
R-HSA-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit
R-HSA-8871194 RAB5 and GAPVD1 bind AP-2
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-437239 Recycling pathway of L1
R-HSA-2132295 MHC class II antigen presentation
R-HSA-8964038 LDL clearance
R-HSA-8866427 VLDLR internalisation and degradation
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-373760 L1CAM interactions
R-HSA-1280218 Adaptive Immune System
R-HSA-8964043 Plasma lipoprotein clearance
R-HSA-4086400 PCP/CE pathway
R-HSA-196025 Formation of annular gap junctions
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-421837 Clathrin derived vesicle budding
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-199991 Membrane Trafficking
R-HSA-166520 Signaling by NTRKs
R-HSA-422475 Axon guidance
R-HSA-168256 Immune System
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-190873 Gap junction degradation
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-5653656 Vesicle-mediated transport
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1266738 Developmental Biology
R-HSA-382551 Transport of small molecules
R-HSA-195721 Signaling by WNT
R-HSA-190828 Gap junction trafficking
R-HSA-162582 Signal Transduction
R-HSA-157858 Gap junction trafficking and regulation

-  Other Names for This Gene
  Alternate Gene Symbols: CLH17, CLH1_HUMAN, CLTC , CLTCL2, D3DU00, ENST00000269122.1, ENST00000269122.2, ENST00000269122.3, ENST00000269122.4, ENST00000269122.5, ENST00000269122.6, ENST00000269122.7, KIAA0034, NM_004859, Q00610, Q6N0A0, Q86TF2, uc317ipt.1, uc317ipt.2
UCSC ID: ENST00000269122.8_11
RefSeq Accession: NM_004859.4
Protein: Q00610 (aka CLH1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.