Human Gene CGA (ENST00000627148.3_7) from GENCODE V47lift37
Description: glycoprotein hormones, alpha polypeptide, transcript variant 2 (from RefSeq NM_000735.4)
Gencode Transcript: ENST00000627148.3_7
Gencode Gene: ENSG00000135346.9_11
Transcript (Including UTRs)
Position: hg19 chr6:87,795,216-87,804,824 Size: 9,609 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr6:87,795,474-87,797,918 Size: 2,445 Coding Exon Count: 3
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: CGA
Diseases sorted by gene-association score: ectopic pregnancy (29), triploidy (18), ovarian remnant syndrome (18), scalp dermatosis (17), ovarian hyperstimulation syndrome (14), choriocarcinoma (13), testicular seminoma (13), mixed germ cell tumor (13), sacrococcygeal teratoma (13), leydig cell hypoplasia (13), polyembryoma (12), intermittent explosive disorder (12), hydatidiform mole, recurrent, 1 (12), orofaciodigital syndrome viii (11), anorchia (10), anovulation (10), oocyte maturation defect 1 (10), adrenomyeloneuropathy (9), ovarian disease (9), trophoblastic neoplasm (8), luteoma (8), testicular cancer (8), varicocele (8), gynecomastia (8), seminoma (7), complete androgen insensitivity syndrome (7), teratoma (7), androgen insensitivity (7), narcissistic personality disorder (7), cryptorchidism (7), pseudohypoparathyroidism, type ib (7), penis agenesis (6), seborrheic dermatitis (6), hermaphroditism (6), hydrocele (6), hyperthyroidism (6), robinow syndrome (6), testicular disease (5), cholera (3), bardet-biedl syndrome (1)
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000476 - Glyco_hormone
Pfam Domains: PF00236 - Glycoprotein hormone
SCOP Domains: 57501 - Cystine-knot cytokines
57863 - ArfGap/RecO-like zinc finger
ModBase Predicted Comparative 3D Structure on Q6I9S8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005179 hormone activity
Biological Process: GO:0010469 regulation of receptor activity
Cellular Component: GO:0005576 extracellular region
Descriptions from all associated GenBank mRNAs
BC010957 - Homo sapiens glycoprotein hormones, alpha polypeptide, mRNA (cDNA clone MGC:13639 IMAGE:4043527), complete cds.BC020782 - Homo sapiens glycoprotein hormones, alpha polypeptide, mRNA (cDNA clone MGC:22783 IMAGE:4732686), complete cds.BC055080 - Homo sapiens glycoprotein hormones, alpha polypeptide, mRNA (cDNA clone MGC:62040 IMAGE:4044086), complete cds.JD561955 - Sequence 542979 from Patent EP1572962.JD073176 - Sequence 54200 from Patent EP1572962.V00518 - Human messenger RNA for chorionic gonadotropin.JD370729 - Sequence 351753 from Patent EP1572962.JD206638 - Sequence 187662 from Patent EP1572962.JD236320 - Sequence 217344 from Patent EP1572962.FJ624078 - Homo sapiens clone F2-351a follicle-stimulating hormone alpha subunit (CGA) mRNA, partial cds.CR457427 - Homo sapiens full open reading frame cDNA clone RZPDo834A0815D for gene CGA, glycoprotein hormones, alpha polypeptide; complete cds, incl. stopcodon.FJ624079 - Homo sapiens clone F1-351a follicle-stimulating hormone alpha subunit (CGA) mRNA, complete cds.HQ448725 - Synthetic construct Homo sapiens clone IMAGE:100072170; CCSB006285_03 glycoprotein hormones, alpha polypeptide (CGA) gene, encodes complete protein.KJ896592 - Synthetic construct Homo sapiens clone ccsbBroadEn_05986 CGA gene, encodes complete protein.KJ905712 - Synthetic construct Homo sapiens clone ccsbBroadEn_15382 CGA gene, encodes complete protein.AK311972 - Homo sapiens cDNA, FLJ92245, Homo sapiens glycoprotein hormones, alpha polypeptide (CGA), mRNA.JD023487 - Sequence 4511 from Patent EP1572962.JD032858 - Sequence 13882 from Patent EP1572962.AK023644 - Homo sapiens cDNA FLJ13582 fis, clone PLACE1009048.
Other Names for This Gene
Alternate Gene Symbols: CGA , ENST00000627148.1, ENST00000627148.2, FSHA , GPA1 , hCG_33165 , NM_000735, Q6I9S8, Q6I9S8_HUMAN, uc327ycb.1, uc327ycb.2UCSC ID: ENST00000627148.3_7RefSeq Accession: NM_000735.4
Protein: Q6I9S8
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.