Human Gene CDYL (ENST00000397588.8_4) from GENCODE V47lift37
Description: chromodomain Y like, transcript variant 1 (from RefSeq NM_004824.4)
Gencode Transcript: ENST00000397588.8_4
Gencode Gene: ENSG00000153046.18_13
Transcript (Including UTRs)
Position: hg19 chr6:4,776,638-4,955,778 Size: 179,141 Total Exon Count: 7 Strand: +
Coding Region
Position: hg19 chr6:4,777,018-4,954,290 Size: 177,273 Coding Exon Count: 7
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: CDYL1_HUMAN
DESCRIPTION: RecName: Full=Chromodomain Y-like protein; Short=CDY-like; EC=2.3.1.48;
FUNCTION: Acts as repressor of transcription (By similarity). Has histone acetyltransferase activity, with a preference for histone H4.CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone].SUBUNIT: Interacts with HDAC1 and HDAC2 via its C-terminal acetyl- CoA-binding domain (By similarity).SUBCELLULAR LOCATION: Nucleus (By similarity).TISSUE SPECIFICITY: Ubiquitous. Expressed at moderate levels in all tissues examined.MISCELLANEOUS: Interaction with HDAC1 or HDAC2 prevents Coenzyme A binding (By similarity).SIMILARITY: Contains 1 chromo domain.SEQUENCE CAUTION: Sequence=CAB43304.1; Type=Miscellaneous discrepancy;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR023780 - Chromo_domain
IPR000953 - Chromo_domain/shadow
IPR016197 - Chromodomain-like
IPR023779 - Chromodomain_CS
IPR001753 - Crotonase_core
Pfam Domains: PF00378 - Enoyl-CoA hydratase/isomerase
PF00385 - Chromo (CHRromatin Organisation MOdifier) domain
PF16113 - Enoyl-CoA hydratase/isomerase
SCOP Domains: 54160 - Chromo domain-like
52096 - ClpP/crotonase
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q9Y232
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AF081258 - Homo sapiens testis-specific chromodomain Y-like protein (CDYL) mRNA, alternatively processed, complete cds.AF081259 - Homo sapiens testis-specific chromodomain Y-like protein (CDYL) mRNA, alternatively processed, complete cds.AK291601 - Homo sapiens cDNA FLJ77415 complete cds, highly similar to Homo sapiens chromodomain protein, Y-like (CDYL), transcript variant 2, mRNA.BC108725 - Homo sapiens chromodomain protein, Y-like, mRNA (cDNA clone MGC:131936 IMAGE:6140263), complete cds.BC119682 - Homo sapiens chromodomain protein, Y-like, mRNA (cDNA clone MGC:149568 IMAGE:40116323), complete cds.AK296985 - Homo sapiens cDNA FLJ57292 complete cds, highly similar to Chromodomain Y-like protein.JD128670 - Sequence 109694 from Patent EP1572962.BC043397 - Homo sapiens chromodomain protein, Y-like, mRNA (cDNA clone IMAGE:6013496), partial cds.DQ582320 - Homo sapiens piRNA piR-32432, complete sequence.BC061516 - Homo sapiens chromodomain protein, Y-like, mRNA (cDNA clone IMAGE:6503066), partial cds.KJ901973 - Synthetic construct Homo sapiens clone ccsbBroadEn_11367 CDYL gene, encodes complete protein.DQ601484 - Homo sapiens piRNA piR-39550, complete sequence.AL050164 - Homo sapiens mRNA; cDNA DKFZp586C1622 (from clone DKFZp586C1622); partial cds.DQ570637 - Homo sapiens piRNA piR-30749, complete sequence.DQ570638 - Homo sapiens piRNA piR-30750, complete sequence.JD535160 - Sequence 516184 from Patent EP1572962.JD099230 - Sequence 80254 from Patent EP1572962.JD482204 - Sequence 463228 from Patent EP1572962.DQ570329 - Homo sapiens piRNA piR-30441, complete sequence.JD087824 - Sequence 68848 from Patent EP1572962.JD097991 - Sequence 79015 from Patent EP1572962.JD491309 - Sequence 472333 from Patent EP1572962.JD533335 - Sequence 514359 from Patent EP1572962.JD298303 - Sequence 279327 from Patent EP1572962.JD062756 - Sequence 43780 from Patent EP1572962.JD037291 - Sequence 18315 from Patent EP1572962.JD072980 - Sequence 54004 from Patent EP1572962.JD339756 - Sequence 320780 from Patent EP1572962.JD354824 - Sequence 335848 from Patent EP1572962.JD053284 - Sequence 34308 from Patent EP1572962.JD550074 - Sequence 531098 from Patent EP1572962.JD206605 - Sequence 187629 from Patent EP1572962.JD357075 - Sequence 338099 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A8K6D6, B4DLG4, CDYL , CDYL1 , CDYL_HUMAN, ENST00000397588.1, ENST00000397588.2, ENST00000397588.3, ENST00000397588.4, ENST00000397588.5, ENST00000397588.6, ENST00000397588.7, NM_004824, Q0VDG7, Q32NC5, Q5VX99, Q6P7T5, Q9BWZ2, Q9Y232, Q9Y424, uc318zdd.1, uc318zdd.2UCSC ID: ENST00000397588.8_4RefSeq Accession: NM_004824.4
Protein: Q9Y232
(aka CDYL1_HUMAN or CDYL_HUMAN)
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.