Human Gene CDK17 (ENST00000261211.8_7) from GENCODE V47lift37
  Description: cyclin dependent kinase 17, transcript variant 1 (from RefSeq NM_002595.5)
Gencode Transcript: ENST00000261211.8_7
Gencode Gene: ENSG00000059758.8_13
Transcript (Including UTRs)
   Position: hg19 chr12:96,672,039-96,794,217 Size: 122,179 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg19 chr12:96,674,020-96,728,614 Size: 54,595 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:96,672,039-96,794,217)mRNA (may differ from genome)Protein (523 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CDK17_HUMAN
DESCRIPTION: RecName: Full=Cyclin-dependent kinase 17; EC=2.7.11.22; AltName: Full=Cell division protein kinase 17; AltName: Full=PCTAIRE-motif protein kinase 2; AltName: Full=Serine/threonine-protein kinase PCTAIRE-2;
FUNCTION: May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBUNIT: Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7 (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.29 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 445.16 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -238.90483-0.495 Picture PostScript Text
3' UTR -432.971981-0.219 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase
PF12330 - Haspin like kinase domain

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q00537
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF208860 - JP 2014500723-A/16363: Polycomb-Associated Non-Coding RNAs.
BC033005 - Homo sapiens PCTAIRE protein kinase 2, mRNA (cDNA clone MGC:26379 IMAGE:4824359), complete cds.
X66360 - H.sapiens mRNA PCTAIRE-2 for serine/threonine protein kinase.
AK315214 - Homo sapiens cDNA, FLJ96208, highly similar to Homo sapiens PCTAIRE protein kinase 2 (PCTK2), mRNA.
AK290011 - Homo sapiens cDNA FLJ75213 complete cds.
AK294698 - Homo sapiens cDNA FLJ57365 complete cds, highly similar to Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22).
MA444437 - JP 2018138019-A/16363: Polycomb-Associated Non-Coding RNAs.
AF086067 - Homo sapiens full length insert cDNA clone YZ18B05.
LF323504 - JP 2014500723-A/131007: Polycomb-Associated Non-Coding RNAs.
LF323503 - JP 2014500723-A/131006: Polycomb-Associated Non-Coding RNAs.
LF323502 - JP 2014500723-A/131005: Polycomb-Associated Non-Coding RNAs.
LF323501 - JP 2014500723-A/131004: Polycomb-Associated Non-Coding RNAs.
JD235423 - Sequence 216447 from Patent EP1572962.
JD316607 - Sequence 297631 from Patent EP1572962.
DQ890808 - Synthetic construct clone IMAGE:100003438; FLH166100.01X; RZPDo839C1186D PCTAIRE protein kinase 2 (PCTK2) gene, encodes complete protein.
KJ891762 - Synthetic construct Homo sapiens clone ccsbBroadEn_01156 CDK17 gene, encodes complete protein.
KJ905248 - Synthetic construct Homo sapiens clone ccsbBroadEn_14731 CDK17 gene, encodes complete protein.
DQ893963 - Synthetic construct Homo sapiens clone IMAGE:100008423; FLH166096.01L; RZPDo839C1185D PCTAIRE protein kinase 2 (PCTK2) gene, encodes complete protein.
LF323500 - JP 2014500723-A/131003: Polycomb-Associated Non-Coding RNAs.
LF323496 - JP 2014500723-A/130999: Polycomb-Associated Non-Coding RNAs.
LF323493 - JP 2014500723-A/130996: Polycomb-Associated Non-Coding RNAs.
LF323492 - JP 2014500723-A/130995: Polycomb-Associated Non-Coding RNAs.
LF323489 - JP 2014500723-A/130992: Polycomb-Associated Non-Coding RNAs.
CU689590 - Synthetic construct Homo sapiens gateway clone IMAGE:100020314 5' read PCTK2 mRNA.
LF323487 - JP 2014500723-A/130990: Polycomb-Associated Non-Coding RNAs.
LF323480 - JP 2014500723-A/130983: Polycomb-Associated Non-Coding RNAs.
MA559081 - JP 2018138019-A/131007: Polycomb-Associated Non-Coding RNAs.
MA559080 - JP 2018138019-A/131006: Polycomb-Associated Non-Coding RNAs.
MA559079 - JP 2018138019-A/131005: Polycomb-Associated Non-Coding RNAs.
MA559078 - JP 2018138019-A/131004: Polycomb-Associated Non-Coding RNAs.
MA559077 - JP 2018138019-A/131003: Polycomb-Associated Non-Coding RNAs.
MA559073 - JP 2018138019-A/130999: Polycomb-Associated Non-Coding RNAs.
MA559070 - JP 2018138019-A/130996: Polycomb-Associated Non-Coding RNAs.
MA559069 - JP 2018138019-A/130995: Polycomb-Associated Non-Coding RNAs.
MA559066 - JP 2018138019-A/130992: Polycomb-Associated Non-Coding RNAs.
MA559064 - JP 2018138019-A/130990: Polycomb-Associated Non-Coding RNAs.
MA559057 - JP 2018138019-A/130983: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K1U6, B2RCQ2, CDK17_HUMAN, ENST00000261211.1, ENST00000261211.2, ENST00000261211.3, ENST00000261211.4, ENST00000261211.5, ENST00000261211.6, ENST00000261211.7, NM_002595, PCTAIRE2, PCTK2, Q00537, Q8NEB8, uc317gnw.1, uc317gnw.2
UCSC ID: ENST00000261211.8_7
RefSeq Accession: NM_002595.5
Protein: Q00537 (aka CDK17_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.