Human Gene CD200R1 (ENST00000308611.8_10) from GENCODE V47lift37
  Description: CD200 receptor 1, transcript variant 1 (from RefSeq NM_138806.4)
Gencode Transcript: ENST00000308611.8_10
Gencode Gene: ENSG00000163606.11_14
Transcript (Including UTRs)
   Position: hg19 chr3:112,640,052-112,693,950 Size: 53,899 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr3:112,642,524-112,693,704 Size: 51,181 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:112,640,052-112,693,950)mRNA (may differ from genome)Protein (348 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MO2R1_HUMAN
DESCRIPTION: RecName: Full=Cell surface glycoprotein CD200 receptor 1; AltName: Full=CD200 cell surface glycoprotein receptor; AltName: Full=Cell surface glycoprotein OX2 receptor 1; Flags: Precursor;
FUNCTION: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
SUBUNIT: Interacts with Human herpesvirus 8 vOX2 protein.
INTERACTION: P41217:CD200; NbExp=2; IntAct=EBI-4314412, EBI-3910563;
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 4: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 2: Secreted.
SUBCELLULAR LOCATION: Isoform 3: Secreted.
TISSUE SPECIFICITY: Expressed in granulocytes, monocytes, most T- cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.
PTM: The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.
SIMILARITY: Belongs to the CD200R family.
SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CD200R1
Diseases sorted by gene-association score: primary hypertrophic osteoarthropathy (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.90 RPKM in Spleen
Total median expression: 14.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.70246-0.275 Picture PostScript Text
3' UTR -560.002472-0.227 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013162 - CD80_C2-set
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub

Pfam Domains:
PF08205 - CD80-like C2-set immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q8TD46
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0016032 viral process
GO:0050776 regulation of immune response

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex


-  Descriptions from all associated GenBank mRNAs
  AK126349 - Homo sapiens cDNA FLJ44378 fis, clone TRACH3035199, highly similar to Cell surface glycoprotein OX2 receptor precursor.
AY358910 - Homo sapiens clone DNA96866 CD200 Receptor (UNQ2522) mRNA, complete cds.
AK304426 - Homo sapiens cDNA FLJ52839 complete cds, highly similar to Cell surface glycoprotein OX2 receptor precursor.
AY284975 - Homo sapiens CD200 cell surface glycoprotein receptor isoform 1 mRNA, complete cds.
AF283760 - Homo sapiens cell surface glycoprotein OX2 receptor (HCRTR2) mRNA, HCRTR2-1 allele, complete cds.
AK293071 - Homo sapiens cDNA FLJ75389 complete cds, highly similar to Homo sapiens CD200 Receptor mRNA.
AF495380 - Homo sapiens cell surface glycoprotein receptor CD200 precursor, mRNA, complete cds.
AF497548 - Homo sapiens CD200 cell surface glycoprotein receptor precursor variant 1 mRNA, complete cds, transcript variant 1.
BC069661 - Homo sapiens CD200 receptor 1, mRNA (cDNA clone MGC:97278 IMAGE:7262527), complete cds.
BC069721 - Homo sapiens CD200 receptor 1, mRNA (cDNA clone MGC:97290 IMAGE:7262539), complete cds.
BC069743 - Homo sapiens CD200 receptor 1, mRNA (cDNA clone MGC:97302 IMAGE:7262551), complete cds.
JD146412 - Sequence 127436 from Patent EP1572962.
BC093890 - Homo sapiens CD200 receptor 1, mRNA (cDNA clone MGC:120925 IMAGE:7939735), complete cds.
BC143393 - Homo sapiens CD200 receptor 1, mRNA (cDNA clone MGC:176916 IMAGE:9051899), complete cds.
HQ447427 - Synthetic construct Homo sapiens clone IMAGE:100070753; CCSB014012_01 CD200 receptor 1 (CD200R1) gene, encodes complete protein.
KJ895479 - Synthetic construct Homo sapiens clone ccsbBroadEn_04873 CD200R1 gene, encodes complete protein.
AF497549 - Homo sapiens CD200 cell surface glycoprotein receptor precursor soluble variant 1 mRNA, complete cds, transcript variant 2.
AF497550 - Homo sapiens CD200 cell surface glycoprotein receptor precursor soluble variant 2 mRNA, complete cds, transcript variant 3.
JD434027 - Sequence 415051 from Patent EP1572962.
JD233146 - Sequence 214170 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8TD46 (Reactome details) participates in the following event(s):

R-HSA-199154 CD200 binds to CD200R
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B3KWZ9, CD200R, CRTR2, E9PCM9, ENST00000308611.1, ENST00000308611.2, ENST00000308611.3, ENST00000308611.4, ENST00000308611.5, ENST00000308611.6, ENST00000308611.7, MO2R1_HUMAN, MOX2R, NM_138806, OX2R, Q52LJ7, Q6IS95, Q6UW94, Q6WHB8, Q8TD44, Q8TD45, Q8TD46, Q8TD52, uc317oin.1, uc317oin.2, UNQ2522/PRO6015
UCSC ID: ENST00000308611.8_10
RefSeq Accession: NM_138806.4
Protein: Q8TD46 (aka MO2R1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.