Human Gene CCR7 (ENST00000246657.2_7) from GENCODE V47lift37
  Description: C-C motif chemokine receptor 7, transcript variant 1 (from RefSeq NM_001838.4)
Gencode Transcript: ENST00000246657.2_7
Gencode Gene: ENSG00000126353.4_11
Transcript (Including UTRs)
   Position: hg19 chr17:38,710,021-38,721,724 Size: 11,704 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr17:38,710,994-38,721,661 Size: 10,668 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:38,710,021-38,721,724)mRNA (may differ from genome)Protein (378 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCR7_HUMAN
DESCRIPTION: RecName: Full=C-C chemokine receptor type 7; Short=C-C CKR-7; Short=CC-CKR-7; Short=CCR-7; AltName: Full=BLR2; AltName: Full=CDw197; AltName: Full=Epstein-Barr virus-induced G-protein coupled receptor 1; Short=EBI1; Short=EBV-induced G-protein coupled receptor 1; AltName: Full=MIP-3 beta receptor; AltName: CD_antigen=CD197; Flags: Precursor;
FUNCTION: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
INDUCTION: By Epstein-Barr virus (EBV).
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Wikipedia; Note=CC chemokine receptors entry; URL="http://en.wikipedia.org/wiki/CC_chemokine_receptors";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCR7
Diseases sorted by gene-association score: chronic actinic dermatitis (12), pars planitis (10), lymphadenitis (8), thymic hyperplasia (7), tetanus (7), chronic lymphocytic leukemia (6), leukemia, acute lymphoblastic 3 (3), common variable immunodeficiency (2), squamous cell carcinoma, head and neck (1), pulmonary fibrosis, idiopathic (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 84.26 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 148.66 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.1063-0.319 Picture PostScript Text
3' UTR -346.60973-0.356 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR001718 - Chemokine_CCR7
IPR000355 - Chemokine_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P32248
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0016493 C-C chemokine receptor activity
GO:0035757 chemokine (C-C motif) ligand 19 binding
GO:0035758 chemokine (C-C motif) ligand 21 binding
GO:0038117 C-C motif chemokine 19 receptor activity
GO:0038121 C-C motif chemokine 21 receptor activity

Biological Process:
GO:0001768 establishment of T cell polarity
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002407 dendritic cell chemotaxis
GO:0002408 myeloid dendritic cell chemotaxis
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002885 positive regulation of hypersensitivity
GO:0002922 positive regulation of humoral immune response
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0030838 positive regulation of actin filament polymerization
GO:0031274 positive regulation of pseudopodium assembly
GO:0031529 ruffle organization
GO:0032496 response to lipopolysaccharide
GO:0032649 regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0034695 response to prostaglandin E
GO:0038115 chemokine (C-C motif) ligand 19 signaling pathway
GO:0038116 chemokine (C-C motif) ligand 21 signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045060 negative thymic T cell selection
GO:0045785 positive regulation of cell adhesion
GO:0045860 positive regulation of protein kinase activity
GO:0046330 positive regulation of JNK cascade
GO:0048872 homeostasis of number of cells
GO:0050706 regulation of interleukin-1 beta secretion
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051491 positive regulation of filopodium assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071345 cellular response to cytokine stimulus
GO:0071731 response to nitric oxide
GO:0072610 interleukin-12 secretion
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0090630 activation of GTPase activity
GO:0097022 lymphocyte migration into lymph node
GO:0097029 mature conventional dendritic cell differentiation
GO:2000147 positive regulation of cell motility
GO:2000510 positive regulation of dendritic cell chemotaxis
GO:2000522 positive regulation of immunological synapse formation
GO:2000525 positive regulation of T cell costimulation
GO:2000526 positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
GO:2000547 regulation of dendritic cell dendrite assembly
GO:2000669 negative regulation of dendritic cell apoptotic process

Cellular Component:
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC035343 - Homo sapiens chemokine (C-C motif) receptor 7, mRNA (cDNA clone MGC:34623 IMAGE:5180758), complete cds.
LP896070 - Sequence 934 from Patent EP3253886.
AK127810 - Homo sapiens cDNA FLJ45911 fis, clone PEBLM2005615, highly similar to C-C chemokine receptor type 7 precursor.
L08176 - Human Epstein-Barr virus induced G-protein coupled receptor mRNA, complete cds.
LP880264 - Sequence 68 from Patent WO2017181111.
LP882095 - Sequence 37 from Patent WO2017181079.
JD555176 - Sequence 536200 from Patent EP1572962.
L31581 - Human G protein-coupled receptor (EBI 1) mRNA, complete cds.
JD442229 - Sequence 423253 from Patent EP1572962.
JD338771 - Sequence 319795 from Patent EP1572962.
JD555754 - Sequence 536778 from Patent EP1572962.
JD140212 - Sequence 121236 from Patent EP1572962.
JD131609 - Sequence 112633 from Patent EP1572962.
JD126745 - Sequence 107769 from Patent EP1572962.
JD097818 - Sequence 78842 from Patent EP1572962.
JD380692 - Sequence 361716 from Patent EP1572962.
JD037377 - Sequence 18401 from Patent EP1572962.
AK310277 - Homo sapiens cDNA, FLJ17319.
JD497411 - Sequence 478435 from Patent EP1572962.
JD400185 - Sequence 381209 from Patent EP1572962.
JD121936 - Sequence 102960 from Patent EP1572962.
JD549752 - Sequence 530776 from Patent EP1572962.
JD434595 - Sequence 415619 from Patent EP1572962.
JD304017 - Sequence 285041 from Patent EP1572962.
JD129986 - Sequence 111010 from Patent EP1572962.
JD149070 - Sequence 130094 from Patent EP1572962.
JD187582 - Sequence 168606 from Patent EP1572962.
JD226754 - Sequence 207778 from Patent EP1572962.
JD226753 - Sequence 207777 from Patent EP1572962.
JD364241 - Sequence 345265 from Patent EP1572962.
JD328976 - Sequence 310000 from Patent EP1572962.
DQ892114 - Synthetic construct clone IMAGE:100004744; FLH183151.01X; RZPDo839G06140D chemokine (C-C motif) receptor 7 (CCR7) gene, encodes complete protein.
AY587876 - Homo sapiens CC chemokine receptor 7 mRNA, complete cds.
LQ493931 - Sequence 10 from Patent WO2016077734.
AK312732 - Homo sapiens cDNA, FLJ93138, highly similar to Homo sapiens chemokine (C-C motif) receptor 7 (CCR7), mRNA.
DQ895308 - Synthetic construct Homo sapiens clone IMAGE:100009768; FLH183147.01L; RZPDo839G06139D chemokine (C-C motif) receptor 7 (CCR7) gene, encodes complete protein.
AB590336 - Synthetic construct DNA, clone: pFN21AE2155, Homo sapiens CCR7 gene for chemokine (C-C motif) receptor 7, without stop codon, in Flexi system.
JD485997 - Sequence 467021 from Patent EP1572962.
MB143808 - JP 2019515670-A/19: METHODS FOR MONITORING AND TREATING CANCER.
MB423131 - JP 2019521641-A/18: METHODS FOR MONITORING AND TREATING CANCER.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_nktPathway - Selective expression of chemokine receptors during T-cell polarization

Reactome (by CSHL, EBI, and GO)

Protein P32248 (Reactome details) participates in the following event(s):

R-HSA-373071 Receptor CCR7 binds CCL19 and 21 ligands
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: CCR7_HUMAN, CMKBR7, EBI1, ENST00000246657.1, EVI1, NM_001838, P32248, uc317etz.1, uc317etz.2
UCSC ID: ENST00000246657.2_7
RefSeq Accession: NM_001838.4
Protein: P32248 (aka CCR7_HUMAN or CKR7_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.