Human Gene CCR2 (ENST00000445132.3_8) from GENCODE V47lift37
  Description: C-C motif chemokine receptor 2, transcript variant B (from RefSeq NM_001123396.4)
Gencode Transcript: ENST00000445132.3_8
Gencode Gene: ENSG00000121807.7_12
Transcript (Including UTRs)
   Position: hg19 chr3:46,395,602-46,402,431 Size: 6,830 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr3:46,399,019-46,400,101 Size: 1,083 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:46,395,602-46,402,431)mRNA (may differ from genome)Protein (360 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCR2_HUMAN
DESCRIPTION: RecName: Full=C-C chemokine receptor type 2; Short=C-C CKR-2; Short=CC-CKR-2; Short=CCR-2; Short=CCR2; AltName: Full=Monocyte chemoattractant protein 1 receptor; Short=MCP-1-R; AltName: CD_antigen=CD192;
FUNCTION: Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
SUBUNIT: Binds to HIV-1 Tat. Interacts with ARRB1.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
INDUCTION: Up-regulated by CREB3.
PTM: N-glycosylated.
POLYMORPHISM: Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423].
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Wikipedia; Note=CC chemokine receptors entry; URL="http://en.wikipedia.org/wiki/CC_chemokine_receptors";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ccr2/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCR2
Diseases sorted by gene-association score: hiv-1 (18), idiopathic anterior uveitis (18), cd3zeta deficiency (10), purulent labyrinthitis (9), cytomegalovirus retinitis (8), acquired immunodeficiency syndrome (8), rhinoscleroma (6), secondary progressive multiple sclerosis (6), lipid pneumonia (5), human immunodeficiency virus infectious disease (4), rheumatoid arthritis (2), macular degeneration, age-related, 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.53 RPKM in Spleen
Total median expression: 34.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.30118-0.274 Picture PostScript Text
3' UTR -719.102330-0.309 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR002237 - Chemokine_CCR2
IPR000355 - Chemokine_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1KAD - Model 1KP1 - Model


ModBase Predicted Comparative 3D Structure on P41597
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0005515 protein binding
GO:0016493 C-C chemokine receptor activity
GO:0019955 cytokine binding
GO:0031727 CCR2 chemokine receptor binding
GO:0035715 chemokine (C-C motif) ligand 2 binding
GO:0035716 chemokine (C-C motif) ligand 12 binding
GO:0035717 chemokine (C-C motif) ligand 7 binding
GO:0042803 protein homodimerization activity

Biological Process:
GO:0001974 blood vessel remodeling
GO:0002407 dendritic cell chemotaxis
GO:0002548 monocyte chemotaxis
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0002829 negative regulation of type 2 immune response
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007259 JAK-STAT cascade
GO:0009611 response to wounding
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010820 positive regulation of T cell chemotaxis
GO:0016032 viral process
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0019233 sensory perception of pain
GO:0019725 cellular homeostasis
GO:0030097 hemopoiesis
GO:0030334 regulation of cell migration
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0035705 T-helper 17 cell chemotaxis
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0043310 negative regulation of eosinophil degranulation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0048873 homeostasis of number of cells within a tissue
GO:0050729 positive regulation of inflammatory response
GO:0050870 positive regulation of T cell activation
GO:0061756 leukocyte adhesion to vascular endothelial cell
GO:0070098 chemokine-mediated signaling pathway
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090265 positive regulation of immune complex clearance by monocytes and macrophages
GO:0097350 neutrophil clearance
GO:1903238 positive regulation of leukocyte tethering or rolling
GO:2000439 positive regulation of monocyte extravasation
GO:2000451 positive regulation of CD8-positive, alpha-beta T cell extravasation
GO:2000464 positive regulation of astrocyte chemotaxis
GO:2000473 positive regulation of hematopoietic stem cell migration

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK292685 - Homo sapiens cDNA FLJ78302 complete cds, highly similar to Homo sapiens chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, mRNA.
AK292920 - Homo sapiens cDNA FLJ75394 complete cds, highly similar to Homo sapiens chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, mRNA.
U03905 - Human monocyte chemoattractant protein 1 receptor (MCP-1RB) alternatively spliced mRNA, complete cds.
BC074751 - Homo sapiens chemokine (C-C motif) receptor 2, mRNA (cDNA clone MGC:103828 IMAGE:30915210), complete cds.
U03882 - Human monocyte chemoattractant protein 1 receptor (MCP-1RA) alternatively spliced mRNA, complete cds.
BC126452 - Homo sapiens chemokine (C-C motif) receptor 2, mRNA (cDNA clone MGC:161730 IMAGE:8992168), complete cds.
BC136396 - Homo sapiens chemokine (C-C motif) receptor 2-like, mRNA (cDNA clone MGC:168006 IMAGE:9020383), complete cds.
FW340050 - Screening.
BC095540 - Homo sapiens chemokine (C-C motif) receptor 2, mRNA (cDNA clone MGC:111760 IMAGE:7001971), complete cds.
AB464480 - Synthetic construct DNA, clone: pF1KB8978, Homo sapiens CCR2 gene for chemokine (C-C motif) receptor 2, without stop codon, in Flexi system.
HQ258202 - Synthetic construct Homo sapiens clone IMAGE:100072511 chemokine (C-C motif) receptor 2 (CCR2) gene, encodes complete protein.
KJ900806 - Synthetic construct Homo sapiens clone ccsbBroadEn_10200 CCR2 gene, encodes complete protein.
D29984 - Homo sapiens mRNA for monocyte chemoattractant protein 1 receptor, complete cds.
X95583 - H.sapiens mRNA for monocyte chemotactic protein-1 (MCP-1) receptor.
JD173927 - Sequence 154951 from Patent EP1572962.
JD121189 - Sequence 102213 from Patent EP1572962.
JD048903 - Sequence 29927 from Patent EP1572962.
JD325591 - Sequence 306615 from Patent EP1572962.
JD376598 - Sequence 357622 from Patent EP1572962.
JD433546 - Sequence 414570 from Patent EP1572962.
JD146480 - Sequence 127504 from Patent EP1572962.
JD315617 - Sequence 296641 from Patent EP1572962.
JD304741 - Sequence 285765 from Patent EP1572962.
JD347213 - Sequence 328237 from Patent EP1572962.
JD199249 - Sequence 180273 from Patent EP1572962.
JD339495 - Sequence 320519 from Patent EP1572962.
JD182020 - Sequence 163044 from Patent EP1572962.
JD144816 - Sequence 125840 from Patent EP1572962.
JD277399 - Sequence 258423 from Patent EP1572962.
JD274795 - Sequence 255819 from Patent EP1572962.
JD437393 - Sequence 418417 from Patent EP1572962.
JD229186 - Sequence 210210 from Patent EP1572962.
JD372560 - Sequence 353584 from Patent EP1572962.
JD199250 - Sequence 180274 from Patent EP1572962.
JD324821 - Sequence 305845 from Patent EP1572962.
JD301915 - Sequence 282939 from Patent EP1572962.
JD423884 - Sequence 404908 from Patent EP1572962.
JD275167 - Sequence 256191 from Patent EP1572962.
JD356977 - Sequence 338001 from Patent EP1572962.
JD519229 - Sequence 500253 from Patent EP1572962.
JD092802 - Sequence 73826 from Patent EP1572962.
JD360785 - Sequence 341809 from Patent EP1572962.
JD038002 - Sequence 19026 from Patent EP1572962.
JD145456 - Sequence 126480 from Patent EP1572962.
JD287587 - Sequence 268611 from Patent EP1572962.
JD434686 - Sequence 415710 from Patent EP1572962.
JD171023 - Sequence 152047 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P41597 (Reactome details) participates in the following event(s):

R-HSA-1973968 Beta-defensins 4A and 103 bind CCR2
R-HSA-373073 Receptors CCR1, 2 and 8 bind CCL16 ligand
R-HSA-8862733 CCR2, CCR3 bind CCL13
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-1461957 Beta defensins
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-6783783 Interleukin-10 signaling
R-HSA-1461973 Defensins
R-HSA-418594 G alpha (i) signalling events
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-449147 Signaling by Interleukins
R-HSA-6803157 Antimicrobial peptides
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168249 Innate Immune System
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A0AVQ3, B2RMT0, CCR2_HUMAN, CMKBR2, ENST00000445132.1, ENST00000445132.2, NM_001123396, O95950, P41597, Q4VBL2, uc320myh.1, uc320myh.2
UCSC ID: ENST00000445132.3_8
RefSeq Accession: NM_001123396.4
Protein: P41597 (aka CCR2_HUMAN or CKR2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.