Human Gene CCR1 (ENST00000296140.4_7) from GENCODE V47lift37
  Description: C-C motif chemokine receptor 1 (from RefSeq NM_001295.3)
Gencode Transcript: ENST00000296140.4_7
Gencode Gene: ENSG00000163823.4_9
Transcript (Including UTRs)
   Position: hg19 chr3:46,243,202-46,249,804 Size: 6,603 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr3:46,244,737-46,245,804 Size: 1,068 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:46,243,202-46,249,804)mRNA (may differ from genome)Protein (355 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q5U003_HUMAN
DESCRIPTION: SubName: Full=Chemokine (C-C motif) receptor 1; SubName: Full=Chemokine (C-C motif) receptor 1, isoform CRA_a;
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCR1
Diseases sorted by gene-association score: immune-complex glomerulonephritis (16), chromoblastomycosis (15), corneal ulcer (9), behcet syndrome* (8), nervous system disease (7), central nervous system disease (7), mesangial proliferative glomerulonephritis (6), multiple sclerosis, disease progression, modifier of (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.36 RPKM in Whole Blood
Total median expression: 106.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.8043-0.135 Picture PostScript Text
3' UTR -421.601535-0.275 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR002236 - Chemokine_CCR1
IPR000355 - Chemokine_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q5U003
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0016493 C-C chemokine receptor activity

Biological Process:
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0070098 chemokine-mediated signaling pathway
GO:0090026 positive regulation of monocyte chemotaxis

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  FW339968 - Screening.
D10925 - Homo sapiens mRNA for HM145, complete cds.
BC064991 - Homo sapiens chemokine (C-C motif) receptor 1, mRNA (cDNA clone MGC:71247 IMAGE:5483554), complete cds.
L10918 - Homo sapiens macrophage inflammatory protein-1-alpha/RANTES receptor mRNA, complete cds.
BC051306 - Homo sapiens chemokine (C-C motif) receptor 1, mRNA (cDNA clone MGC:59862 IMAGE:5485097), complete cds.
JD555214 - Sequence 536238 from Patent EP1572962.
JD430031 - Sequence 411055 from Patent EP1572962.
JD297523 - Sequence 278547 from Patent EP1572962.
JD174077 - Sequence 155101 from Patent EP1572962.
JD067807 - Sequence 48831 from Patent EP1572962.
JD416159 - Sequence 397183 from Patent EP1572962.
JD345496 - Sequence 326520 from Patent EP1572962.
JD334254 - Sequence 315278 from Patent EP1572962.
JD098768 - Sequence 79792 from Patent EP1572962.
JD203044 - Sequence 184068 from Patent EP1572962.
L09230 - Human C-C chemokine receptor type 1 (C-C CKR-1) mRNA, complete cds.
JD119975 - Sequence 100999 from Patent EP1572962.
JD515843 - Sequence 496867 from Patent EP1572962.
JD503832 - Sequence 484856 from Patent EP1572962.
JD224015 - Sequence 205039 from Patent EP1572962.
JD334892 - Sequence 315916 from Patent EP1572962.
JD156968 - Sequence 137992 from Patent EP1572962.
JD500856 - Sequence 481880 from Patent EP1572962.
JD221014 - Sequence 202038 from Patent EP1572962.
EU831462 - Synthetic construct Homo sapiens clone HAIB:100066491; DKFZo008F0417 chemokine (C-C motif) receptor 1 protein (CCR1) gene, encodes complete protein.
EU831549 - Synthetic construct Homo sapiens clone HAIB:100066578; DKFZo004F0418 chemokine (C-C motif) receptor 1 protein (CCR1) gene, encodes complete protein.
KJ890937 - Synthetic construct Homo sapiens clone ccsbBroadEn_00331 CCR1 gene, encodes complete protein.
BT019908 - Homo sapiens chemokine (C-C motif) receptor 1 mRNA, complete cds.
BT019909 - Homo sapiens chemokine (C-C motif) receptor 1 mRNA, complete cds.
AB529226 - Synthetic construct DNA, clone: pF1KB8806, Homo sapiens CCR1 gene for chemokine (C-C motif) receptor 1, without stop codon, in Flexi system.
CU690798 - Synthetic construct Homo sapiens gateway clone IMAGE:100022448 5' read CCR1 mRNA.
JD330623 - Sequence 311647 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_nktPathway - Selective expression of chemokine receptors during T-cell polarization

-  Other Names for This Gene
  Alternate Gene Symbols: A0A024R2P9, CCR1 , ENST00000296140.1, ENST00000296140.2, ENST00000296140.3, hCG_15324 , NM_001295, Q5U003, Q5U003_HUMAN, uc317lrn.1, uc317lrn.2
UCSC ID: ENST00000296140.4_7
RefSeq Accession: NM_001295.3
Protein: Q5U003

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.