ID:CCNE1_HUMAN DESCRIPTION: RecName: Full=G1/S-specific cyclin-E1; FUNCTION: Essential for the control of the cell cycle at the G1/S (start) transition. SUBUNIT: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation. INTERACTION: P38398:BRCA1; NbExp=2; IntAct=EBI-519526, EBI-349905; P24941:CDK2; NbExp=9; IntAct=EBI-519526, EBI-375096; P38936:CDKN1A; NbExp=7; IntAct=EBI-519526, EBI-375077; P46527:CDKN1B; NbExp=6; IntAct=EBI-519526, EBI-519280; Q96PU4:UHRF2; NbExp=4; IntAct=EBI-519526, EBI-625304; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. PTM: Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Ubiquitinated by UHRF2; appears to occur independently of phosphorylation. SIMILARITY: Belongs to the cyclin family. Cyclin E subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccne1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P24864
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK291549 - Homo sapiens cDNA FLJ75709 complete cds, highly similar to Homo sapiens cyclin E1 (CCNE1), transcript variant 1, mRNA. KF672848 - Homo sapiens cyclin E variant ex5del (CCNE1) mRNA, complete cds, alternatively spliced. KR134287 - Homo sapiens clone 2-9 pluripotent specific cyclin E1 (pCCNE1) mRNA, partial cds. BC035498 - Homo sapiens cyclin E1, mRNA (cDNA clone MGC:20493 IMAGE:3841192), complete cds. JD416432 - Sequence 397456 from Patent EP1572962. JD458478 - Sequence 439502 from Patent EP1572962. JD422447 - Sequence 403471 from Patent EP1572962. JD172637 - Sequence 153661 from Patent EP1572962. DQ893383 - Synthetic construct clone IMAGE:100006013; FLH199455.01X; RZPDo839A1182D cyclin E1 (CCNE1) gene, encodes complete protein. DQ896703 - Synthetic construct Homo sapiens clone IMAGE:100011163; FLH199361.01L; RZPDo839A1181D cyclin E1 (CCNE1) gene, encodes complete protein. CU690088 - Synthetic construct Homo sapiens gateway clone IMAGE:100021955 5' read CCNE1 mRNA. AB590337 - Synthetic construct DNA, clone: pFN21AE1359, Homo sapiens CCNE1 gene for cyclin E1, without stop codon, in Flexi system. KJ890844 - Synthetic construct Homo sapiens clone ccsbBroadEn_00238 CCNE1 gene, encodes complete protein. M73812 - Human cyclin E mRNA sequence. KF672847 - Homo sapiens cyclin E variant ex7del (CCNE1) mRNA, complete cds, alternatively spliced. M74093 - Human cyclin mRNA. JD313974 - Sequence 294998 from Patent EP1572962. JD461710 - Sequence 442734 from Patent EP1572962. JD271557 - Sequence 252581 from Patent EP1572962. JD464038 - Sequence 445062 from Patent EP1572962. JD462304 - Sequence 443328 from Patent EP1572962. JD235782 - Sequence 216806 from Patent EP1572962. JD264471 - Sequence 245495 from Patent EP1572962. JD039247 - Sequence 20271 from Patent EP1572962. JD129933 - Sequence 110957 from Patent EP1572962. JD295332 - Sequence 276356 from Patent EP1572962. JD485111 - Sequence 466135 from Patent EP1572962. JD551335 - Sequence 532359 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_cellcyclePathway - Cyclins and Cell Cycle Regulation h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition h_g1Pathway - Cell Cycle: G1/S Check Point h_p27Pathway - Regulation of p27 Phosphorylation during Cell Cycle Progression h_p53Pathway - p53 Signaling Pathway h_skp2e2fPathway - E2F1 Destruction Pathway h_mcmPathway - CDK Regulation of DNA Replication h_fbw7Pathway - Cyclin E Destruction Pathway
Reactome (by CSHL, EBI, and GO)
Protein P24864 (Reactome details) participates in the following event(s):
R-HSA-69191 Formation of Cyclin E:Cdk2 complexes R-HSA-69199 Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A R-HSA-69195 Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1 R-HSA-188386 Association of Rb with Cyclin E:Cdk2 complexes R-HSA-188350 CAK-mediated phosphorylation of Cyclin E:Cdk2 R-HSA-69562 Inactivation of Cyclin E:Cdk2 complexes by p27/p21 R-HSA-157906 Translocation of Cyclin E:Cdk2 complex to the nucleus R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) R-HSA-188390 Cyclin E:Cdk2-mediated phosphorylation of Rb R-HSA-1363303 p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 R-HSA-1363306 p130 (RBL2) binds Cyclin E/A:CDK2 R-HSA-1363311 p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 R-HSA-1363314 p107 (RBL1) binds CyclinE/A:CDK2 R-HSA-8848414 Activated PTK6 binds CDKN1B R-HSA-8848436 PTK6 phosphorylates CDKN1B R-HSA-187520 Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 R-HSA-187552 Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex R-HSA-69005 Cdc6 protein is phosphorylated by CDK R-HSA-187575 Ubiquitination of phospho-p27/p21 R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69205 G1/S-Specific Transcription R-HSA-69563 p53-Dependent G1 DNA Damage Response R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-69206 G1/S Transition R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint R-HSA-2559583 Cellular Senescence R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes R-HSA-1538133 G0 and Early G1 R-HSA-8849470 PTK6 Regulates Cell Cycle R-HSA-453279 Mitotic G1-G1/S phases R-HSA-390466 Chaperonin-mediated protein folding R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69615 G1/S DNA Damage Checkpoints R-HSA-2262752 Cellular responses to stress R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-8848021 Signaling by PTK6 R-HSA-69278 Cell Cycle (Mitotic) R-HSA-391251 Protein folding R-HSA-69242 S Phase R-HSA-69052 Switching of origins to a post-replicative state R-HSA-69620 Cell Cycle Checkpoints R-HSA-8953897 Cellular responses to external stimuli R-HSA-212436 Generic Transcription Pathway R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases R-HSA-1640170 Cell Cycle R-HSA-392499 Metabolism of proteins R-HSA-69239 Synthesis of DNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-162582 Signal Transduction R-HSA-69306 DNA Replication R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
