ID:CCNB1_HUMAN DESCRIPTION: RecName: Full=G2/mitotic-specific cyclin-B1; FUNCTION: Essential for the control of the cell cycle at the G2/M (mitosis) transition. SUBUNIT: Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. INTERACTION: Q9NPC3:CCNB1IP1; NbExp=2; IntAct=EBI-495332, EBI-745269; P06493:CDK1; NbExp=4; IntAct=EBI-495332, EBI-444308; Q99640:PKMYT1; NbExp=2; IntAct=EBI-495332, EBI-495308; Q96PU4:UHRF2; NbExp=2; IntAct=EBI-495332, EBI-625304; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly destroyed at mitosis. PTM: Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases. PTM: Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site. SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CCNB1ID951ch5q13.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccnb1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P14635
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF209886 - JP 2014500723-A/17389: Polycomb-Associated Non-Coding RNAs. AK289431 - Homo sapiens cDNA FLJ75563 complete cds, highly similar to Homo sapiens cyclin B1 (CCNB1), mRNA. BC006510 - Homo sapiens cyclin B1, mRNA (cDNA clone MGC:2548 IMAGE:2963100), complete cds. JD428538 - Sequence 409562 from Patent EP1572962. LF332450 - JP 2014500723-A/139953: Polycomb-Associated Non-Coding RNAs. M25753 - Human cyclin B mRNA, 3' end. JD424254 - Sequence 405278 from Patent EP1572962. JD280768 - Sequence 261792 from Patent EP1572962. JD525478 - Sequence 506502 from Patent EP1572962. JD389954 - Sequence 370978 from Patent EP1572962. JD199350 - Sequence 180374 from Patent EP1572962. AB590575 - Synthetic construct DNA, clone: pFN21AE2239, Homo sapiens CCNB1 gene for cyclin B1, without stop codon, in Flexi system. DQ892975 - Synthetic construct clone IMAGE:100005605; FLH191329.01X; RZPDo839C0177D cyclin B1 (CCNB1) gene, encodes complete protein. BT020128 - Homo sapiens cyclin B1 mRNA, complete cds. AM851053 - Homo sapiens mRNA for cyclin B1 (CCNB1V gene), short variant. MA264866 - JP 2017508467-A/186: PHARMACEUTICAL COMPOSITIONS COMPRISING RNA AND USE FOR TREATING CANCER. MS942542 - Sequence 186 from Patent EP3116513. LF332447 - JP 2014500723-A/139950: Polycomb-Associated Non-Coding RNAs. LF332446 - JP 2014500723-A/139949: Polycomb-Associated Non-Coding RNAs. MA264868 - JP 2017508467-A/188: PHARMACEUTICAL COMPOSITIONS COMPRISING RNA AND USE FOR TREATING CANCER. MS942544 - Sequence 188 from Patent EP3116513. LF332445 - JP 2014500723-A/139948: Polycomb-Associated Non-Coding RNAs. MA264870 - JP 2017508467-A/190: PHARMACEUTICAL COMPOSITIONS COMPRISING RNA AND USE FOR TREATING CANCER. MS942546 - Sequence 190 from Patent EP3116513. AY027761 - Homo sapiens MS6.1 cyclin B1 mRNA, partial cds. AY027762 - Homo sapiens MS6.2 cyclin B1 mRNA, partial cds. AY027763 - Homo sapiens MS6.3 cyclin B1 mRNA, partial cds. AY027765 - Homo sapiens MS6.5 cyclin B1 mRNA, partial cds. AY027766 - Homo sapiens clone MS6.6 nonfunctional cyclin B1 mRNA, partial cds. AY027767 - Homo sapiens MS6.7 cyclin B1 mRNA, partial cds. AY027768 - Homo sapiens MS6.9 cyclin B1 mRNA, partial cds. AY027769 - Homo sapiens MS6.10 cyclin B1 mRNA, partial cds. AY027770 - Homo sapiens 3.1 cyclin B1 mRNA, partial cds. AY027764 - Homo sapiens MS6.4 cyclin B1 mRNA, partial cds. LF332443 - JP 2014500723-A/139946: Polycomb-Associated Non-Coding RNAs. LF332442 - JP 2014500723-A/139945: Polycomb-Associated Non-Coding RNAs. DM110833 - Novel Cancer Marker and Use Thereof. MA264872 - JP 2017508467-A/192: PHARMACEUTICAL COMPOSITIONS COMPRISING RNA AND USE FOR TREATING CANCER. MS942548 - Sequence 192 from Patent EP3116513. LF332441 - JP 2014500723-A/139944: Polycomb-Associated Non-Coding RNAs. MA568027 - JP 2018138019-A/139953: Polycomb-Associated Non-Coding RNAs. MA568024 - JP 2018138019-A/139950: Polycomb-Associated Non-Coding RNAs. MA568023 - JP 2018138019-A/139949: Polycomb-Associated Non-Coding RNAs. MA568022 - JP 2018138019-A/139948: Polycomb-Associated Non-Coding RNAs. MA568020 - JP 2018138019-A/139946: Polycomb-Associated Non-Coding RNAs. MA568019 - JP 2018138019-A/139945: Polycomb-Associated Non-Coding RNAs. MA568018 - JP 2018138019-A/139944: Polycomb-Associated Non-Coding RNAs. MA445463 - JP 2018138019-A/17389: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_ptc1Pathway - Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle h_EfpPathway - Estrogen-responsive protein Efp controls cell cycle and breast tumors growth h_g2Pathway - Cell Cycle: G2/M Checkpoint h_srcRPTPPathway - Activation of Src by Protein-tyrosine phosphatase alpha h_akap95Pathway - AKAP95 role in mitosis and chromosome dynamics h_cellcyclePathway - Cyclins and Cell Cycle Regulation h_mPRPathway - How Progesterone Initiates the Oocyte Maturation h_stathminPathway - Stathmin and breast cancer resistance to antimicrotubule agents
Reactome (by CSHL, EBI, and GO)
Protein P14635 (Reactome details) participates in the following event(s):
R-HSA-113638 Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation R-HSA-170076 CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes R-HSA-170072 Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm R-HSA-170153 Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases R-HSA-170070 Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes R-HSA-170126 Phosphorylation of Cyclin B1 in the CRS domain R-HSA-174120 Association of Cyclin B:Cdc2 with Cdc20:APC/C complex R-HSA-6803875 SFN dimer binds CDK1 and CCNB1 R-HSA-170057 Formation of Cyclin B:Cdc2 complexes R-HSA-170131 Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes R-HSA-170044 Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus R-HSA-174122 Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 R-HSA-174132 Free APC/C phosphorylated by Cyclin B:Cdc2 R-HSA-174251 Phosphorylation of Cdh1 by Cyclin B1:Cdc2 R-HSA-380278 CCNB1:p-T160-CDK1 phosphorylates NUMA1 R-HSA-2245218 CDK1 phosphorylates PHF8 R-HSA-2294600 CDK1 phosphorylates condensin II subunit NCAPD3 R-HSA-2430533 CDK1 phosphorylates MASTL R-NUL-2434198 CDK1 phosphorylates Mastl R-HSA-5195402 CDK1 phosphorylates LPIN R-HSA-5244669 CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments R-HSA-9009282 CDK1 phosphorylates RUNX2 R-HSA-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex R-HSA-170161 Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B R-HSA-170055 Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes R-HSA-4088024 CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 R-HSA-2172183 Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB R-NUL-2422970 Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-2468293 CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms R-HSA-2514854 CDK1 phosphorylates condensin I R-HSA-2984220 CDK1:CCNB phosphorylates NEK9 R-HSA-2990882 CDK1 phosphorylates NUP98 R-HSA-4086410 CDK1 phosphorylates BORA R-HSA-8852306 Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends R-HSA-156711 Polo-like kinase mediated events R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478 G2/M DNA replication checkpoint R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-69275 G2/M Transition R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-113510 E2F mediated regulation of DNA replication R-HSA-69481 G2/M Checkpoints R-HSA-69473 G2/M DNA damage checkpoint R-HSA-176417 Phosphorylation of Emi1 R-HSA-176412 Phosphorylation of the APC/C R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-68875 Mitotic Prophase R-HSA-2299718 Condensation of Prophase Chromosomes R-HSA-2465910 MASTL Facilitates Mitotic Progression R-HSA-4419969 Depolymerisation of the Nuclear Lamina R-HSA-8878166 Transcriptional regulation by RUNX2 R-HSA-453274 Mitotic G2-G2/M phases R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes R-HSA-69206 G1/S Transition R-HSA-69620 Cell Cycle Checkpoints R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-174143 APC/C-mediated degradation of cell cycle proteins R-HSA-68886 M Phase R-HSA-2980766 Nuclear Envelope Breakdown R-HSA-212436 Generic Transcription Pathway R-HSA-69278 Cell Cycle (Mitotic) R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2514853 Condensation of Prometaphase Chromosomes R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-453279 Mitotic G1-G1/S phases R-HSA-1640170 Cell Cycle R-HSA-453276 Regulation of mitotic cell cycle R-HSA-73857 RNA Polymerase II Transcription R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-68877 Mitotic Prometaphase R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
