Human Gene CCNA1 (ENST00000255465.8_5) from GENCODE V47lift37
Description: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. (from UniProt P78396) Gencode Transcript: ENST00000255465.8_5 Gencode Gene: ENSG00000133101.10_8 Transcript (Including UTRs) Position: hg19 chr13:37,006,632-37,017,007 Size: 10,376 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chr13:37,007,194-37,016,802 Size: 9,609 Coding Exon Count: 8
ID:CCNA1_HUMAN DESCRIPTION: RecName: Full=Cyclin-A1; FUNCTION: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. SUBUNIT: Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 and KLHDC9. INTERACTION: P38936:CDKN1A; NbExp=2; IntAct=EBI-375065, EBI-375077; SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Very high levels in testis and very low levels in brain. Also found in myeloid Leukemia cell lines. DEVELOPMENTAL STAGE: Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases. PTM: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78396
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0007049 cell cycle GO:0007141 male meiosis I GO:0007283 spermatogenesis GO:0016579 protein deubiquitination GO:0051301 cell division
AK316392 - Homo sapiens cDNA, FLJ79291 complete cds, highly similar to Cyclin-A1. AK301897 - Homo sapiens cDNA FLJ50745 complete cds, highly similar to Cyclin-A1. AK314261 - Homo sapiens cDNA, FLJ95009, highly similar to Homo sapiens cyclin A1 (CCNA1), mRNA. AK225146 - Homo sapiens mRNA for cyclin A1 variant, clone: CBL05761. U66838 - Human cyclin A1 mRNA, complete cds. BC035479 - Homo sapiens cyclin A1, mRNA (cDNA clone IMAGE:5172335). BC036346 - Homo sapiens cyclin A1, mRNA (cDNA clone MGC:34627 IMAGE:5172478), complete cds. HM005347 - Homo sapiens clone HTL-T-34 testicular tissue protein Li 34 mRNA, complete cds. AB462995 - Synthetic construct DNA, clone: pF1KB8631, Homo sapiens CCNA1 gene for cyclin A1, without stop codon, in Flexi system. AM393372 - Synthetic construct Homo sapiens clone IMAGE:100002589 for hypothetical protein (CCNA1 gene). DQ894488 - Synthetic construct Homo sapiens clone IMAGE:100008948; FLH170913.01L; RZPDo839D0199D cyclin A1 (CCNA1) gene, encodes complete protein. DQ891303 - Synthetic construct clone IMAGE:100003933; FLH170917.01X; RZPDo839D01100D cyclin A1 (CCNA1) gene, encodes complete protein. BT019577 - Homo sapiens cyclin A1 mRNA, complete cds. U97680 - Homo sapiens cyclin A1 mRNA, partial cds. JD563054 - Sequence 544078 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_cellcyclePathway - Cyclins and Cell Cycle Regulation h_g1Pathway - Cell Cycle: G1/S Check Point h_skp2e2fPathway - E2F1 Destruction Pathway
Reactome (by CSHL, EBI, and GO)
Protein P78396 (Reactome details) participates in the following event(s):
R-HSA-170084 Formation of Cyclin A:Cdc2 complexes R-HSA-174054 Formation of Cyclin A:Cdk2 complexes R-HSA-69754 Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes R-HSA-5697009 USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 R-HSA-174164 Phosphorylation of Cyclin A:Cdk2 at Tyr 15 R-HSA-187934 Inactivation of Cyclin A:Cdk2 complexes by p27/p21 R-HSA-187949 CAK-mediated phosphorylation of Cyclin A:Cdk2 R-HSA-174110 Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 R-HSA-174273 Translocation of Cyclin A:Cdk2 complexes to the nucleus R-HSA-170087 CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes R-HSA-170088 Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus R-HSA-170156 Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes R-HSA-170158 Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes R-HSA-187937 Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 R-HSA-188371 Association of Cyclin A:Cdk2 with Cdh1 R-HSA-3788708 CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 R-HSA-5684081 MRN complex binds CDK2 and RBBP8 R-HSA-5684096 CDK2 phosphorylates RBBP8 R-HSA-170116 Myt-1 mediated phosphorylation of Cyclin A:Cdc2 R-HSA-174171 Association of Cyclin A with the APC/C R-HSA-187916 Cyclin A:Cdk2 mediated phosphorylation of p27/p21 R-HSA-187959 Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) R-HSA-174079 Phosphorylation of Cdh1 by Cyclin A:Cdk2 R-HSA-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 R-HSA-68944 Orc1 is phosphorylated by cyclin A/CDK2 R-HSA-187948 Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 R-HSA-6805109 CDK2 phosphorylates TP53 R-HSA-1363303 p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 R-HSA-1363306 p130 (RBL2) binds Cyclin E/A:CDK2 R-HSA-1363311 p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 R-HSA-1363314 p107 (RBL1) binds CyclinE/A:CDK2 R-HSA-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex R-HSA-6793661 (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 R-HSA-187520 Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 R-HSA-187552 Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex R-HSA-69005 Cdc6 protein is phosphorylated by CDK R-HSA-4088024 CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 R-HSA-187575 Ubiquitination of phospho-p27/p21 R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-69205 G1/S-Specific Transcription R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-170145 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes R-HSA-5689880 Ub-specific processing proteases R-HSA-69563 p53-Dependent G1 DNA Damage Response R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-68911 G2 Phase R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-5693607 Processing of DNA double-strand break ends R-HSA-69206 G1/S Transition R-HSA-69275 G2/M Transition R-HSA-69242 S Phase R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-5688426 Deubiquitination R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint R-HSA-2559583 Cellular Senescence R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-453274 Mitotic G2-G2/M phases R-HSA-174143 APC/C-mediated degradation of cell cycle proteins R-HSA-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-68949 Orc1 removal from chromatin R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-1538133 G0 and Early G1 R-HSA-453279 Mitotic G1-G1/S phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-597592 Post-translational protein modification R-HSA-69615 G1/S DNA Damage Checkpoints R-HSA-2262752 Cellular responses to stress R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-6804757 Regulation of TP53 Degradation R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-453276 Regulation of mitotic cell cycle R-HSA-5693538 Homology Directed Repair R-HSA-69052 Switching of origins to a post-replicative state R-HSA-5633007 Regulation of TP53 Activity R-HSA-1640170 Cell Cycle R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-392499 Metabolism of proteins R-HSA-69620 Cell Cycle Checkpoints R-HSA-8953897 Cellular responses to external stimuli R-HSA-212436 Generic Transcription Pathway R-HSA-6806003 Regulation of TP53 Expression and Degradation R-HSA-5693532 DNA Double-Strand Break Repair R-HSA-69239 Synthesis of DNA R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-73857 RNA Polymerase II Transcription R-HSA-73894 DNA Repair R-HSA-69306 DNA Replication R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
